Outcome of first‐trimester chorionic villus sampling for genetic investigation in multiple pregnancy

Abstract

Chorionicity in twin pregnancy can be determined with certainty between 7 and 12 weeks of gestation; in cases of confluent placentas reliability is provided by determining the presence or absence of the lambda sign. This study indicates that first-trimester transabdominal chorionic villus sampling is a highly efficient, reliable, and relatively safe approach for genetic diagnosis in twin pregnancies. Although a precise evaluation of the relative risks of chorionic villus sampling and mid-trimester amniocentesis in twins must await randomized control studies, the advantages of a first-trimester diagnosis to enable early decision-making about selective fetal reduction are obvious.

Towards a Fully Synthetic MUC1‐Based Anticancer Vaccine: Efficient Conjugation of Glycopeptides with Mono‐, Di‐, and Tetravalent Lipopeptides Using Click Chemistry

“…Twin pregnancies were classified as dichorionic or monochorionic according to the presence or absence of an extension of placental tissue into the base of the intertwin membrane, visualized by transabdominal ultrasonography as the lambda or T‐sign, respectively5, 6. At the time of the ultrasound examination fetuses were numbered depending on the proximity of the sac to the internal os7.…”

Prenatal diagnosis of Herlitz junctional epidermolysis bullosa in nonidentical twins

“…It is conducted earlier than amniocentesis and therefore has the advantage of allowing selective termination early in the first trimester, when the procedure‐related risk of miscarriage is small. Indeed, several studies have shown no differences in fetal or perinatal losses between CVS in twin or single fetuses 6,7 . However, selective termination is more hazardous in monochorionic than dichorionic pregnancies, with a considerable increase in morbidity and mortality 8 .…”

“…Indeed, several studies have shown no differences in fetal or perinatal losses between CVS in twin or single fetuses. 6,7 However, selective termination is more hazardous in monochorionic than dichorionic pregnancies, with a considerable increase in morbidity and mortality. 8 In our case, the twins were dichorionic and termination was performed by injecting potassium Figure 1 Pedigree of the family and LAMB3 gene haplotypes.…”

Stratégies de diagnostic prénatal et prise en charge des pathologies liées aux grossesses multiples

“…Entre des mains expérimentées, il semble que la biopsie de trophoblaste soit au moins aussi sûre que l'amniocentèse dans les grossesses gémellaires [13][14][15]. Les prélèvements foetaux sont plus difficiles dans les grossesses multiples : il peut y avoir des problèmes d'identification ou des difficultés d'accès au trophoblaste ou au liquide amniotique à analyser.…”