Outcome of fetuses with congenital parvovirus B19 infection: systematic review and meta‐analysis

Bascietto, F.; Liberati, Marco; Murgano, Daniela; Buca, D.; Iacovelli, Antonia; Flacco, Maria Elena; Manzoli, Lamberto; Familiari, Alessandra; Scambia, Giovanni; D’Antonio, Francesco

doi:10.1002/uog.19092

Cited by 60 publications

(61 citation statements)

References 51 publications

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“…Moreover, mature erythrocytes are transfused, which are less susceptible to the influence of parvovirus, and therefore likely to persist for the normal erythrocyte half-life of 120 days. A meta-analysis of observational studies showed that intrauterine blood transfusion resulted in resolution of hydrops in 55% of affected fetuses, whereas resolution of anemia on follow-up scans was reported in all non-hydropic fetuses 140 . Finally, transfused blood, if taken from a donor seropositive for parvovirus IgG, can confer some passive immunity on the fetus.…”

Section: Management Of Maternal and Fetal Parvovirus B19 Infectionmentioning

confidence: 99%

ISUOG Practice Guidelines: role of ultrasound in congenital infection

Khalil

Sotiriadis

Chaoui³

et al. 2020

Ultrasound in Obstet & Gyne

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130

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ISUOG Practice Guidelines: role of ultrasound in congenital infection Clinical Standards Committee The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice, and high-quality teaching and research related to diagnostic imaging in women's healthcare. The ISUOG Clinical Standards Committee (CSC) has a remit to develop Practice Guidelines and Consensus Statements as educational recommendations that provide healthcare practitioners with a consensus-based approach, from experts, for diagnostic imaging. They are intended to reflect what is considered by ISUOG to be the best practice at the time at which they are issued. Although ISUOG has made every effort to ensure that Guidelines are accurate when issued, neither the Society nor any of its employees or members accepts any liability for the consequences of any inaccurate or misleading data, opinions or statements issued by the CSC. The ISUOG CSC documents are not intended to establish a legal standard of care, because interpretation of the evidence that underpins the Guidelines may be influenced by individual circumstances, local protocol and available resources. Approved Guidelines can be distributed freely with the permission of ISUOG (

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Section: Management Of Maternal and Fetal Parvovirus B19 Infectionmentioning

confidence: 99%

ISUOG Practice Guidelines: role of ultrasound in congenital infection

Khalil

Sotiriadis

Chaoui³

et al. 2020

Ultrasound in Obstet & Gyne

Self Cite

130

View full text Add to dashboard Cite

show abstract

“…Fetal hydrops, or abnormal accumulation of fluid/edema in two or more compartments, is common in the setting of Parvovirus B19 infection, with a metaanalysis finding a 9.3% pooled incidence, as well as an increased risk of fetal loss, spontaneous abortion and stillbirth [36]. Parvovirus B19 is among the most common causes of non-immune fetal hydrops, and while spontaneous resolution of infection can occur, only about 5% of cases with hydrops will show spontaneous resolution of the infection with disappearance of hydrops on follow up ultrasounds [37].…”

Section: Parvovirus B19mentioning

confidence: 99%

“…In utero transfusions (IUT) are often necessary and reduce mortality rates when compared to expectant management. A metaanalysis found IUT was performed in 78% of hydropic fetuses compared to 29% of non-hydropic fetuses, with the difference likely due to the hydropic fetuses at higher risk of demise [37]. Complications may occur in up to 5% of cases, especially if the fetus is likely more sensitive to vascular overload [38].…”

Section: Parvovirus B19mentioning

confidence: 99%

The Impact of Maternal Infection on the Neonate

Ko¹,

Dehority²,

Maxwell³

2021

Congenital Anomalies in Newborn Infants - Clinical and Etiopathological Perspectives

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Maternal infection is a common occurrence during pregnancy, with a substantial impact on the infant. Some infections result in impaired development in utero and even death of the fetus. Other infections may be insidious in the mother but result in growth impairment and hearing loss in the infant. A growing body of evidence suggests that even infections such as chorioamnionitis, thought to have no longterm impact on the infant, may alter fetal development. This chapter will review congenital infections and their impact on neonatal outcomes, as well as newer findings suggesting that acute infection may result in adverse changes in the infant. We will explore novel mechanisms of pathogenesis and virulence, as well as areas that continue with ongoing research.

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“…For sophisticated epidemiological models and related data, see [13][14][15]. The virus can be transmitted from mother to fetus posing a risk of fetal damage that should prompt for an antenatal assessment of risk of fetal infections and diagnostic attention towards the development of intrauterine infections (see [16][17][18] for recent reviews). Finally, due to a viremic phase with high viral load, there is a risk of iatrogenic transmission of the virus via blood and blood-derived products, implying blood and blood product safety issues (see [19,20] for recent reviews).…”

Section: Transmissionmentioning

confidence: 99%

“…Hydrops may eventually cause fetal death, but frequently the fetus can recover without persistent developmental damage. In the third trimester the overall risk of fetal damage decreases to background values, although late intrauterine fetal death can occur [17,59]. Conservative management of documented infections is advised, with an indication for improved survival following intrauterine transfusions in case of documented fetal anemia below a threshold level [60].…”

Section: Fetal Infectionmentioning

confidence: 99%

The clinical use of parvovirus B19 assays: recent advances

Gallinella

2018

Expert Review of Molecular Diagnostics

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Parvovirus B19 (B19V), a single-stranded DNA virus in the family Parvoviridae, is a human pathogenic virus, characterized by a selective but not exclusive tropism for erythroid progenitor cells. Widely diffuse, it is responsible for an ample range of clinical manifestations, whose characteristics and outcomes depend on the interplay between the viral properties and the physiological and immune status of the infected individuals. The complexity of virus-host relationship and the diversity of the clinical course of infection pose a diagnostic challenge that may require non-trivial solutions. Areas covered: The review includes an updated description of the course of B19V infection in its complexity and diversity of pathogenetic mechanisms, discusses the consequent requirements for different and appropriated diagnostic approaches, presents the main diagnostic techniques, more recent technical advancements, and their application to the diverse clinical situations. Expert commentary: The complex scenario of the infectious process and the diversity in possible pathogenetic mechanisms make necessary a multi-parametric approach for an accurate and informative laboratory diagnosis of B19V infection, combining as much as possible the molecular detection of viral components, mainly viral DNA, to commonly followed immunological detection of virus-specific antibodies and a critical assessment of laboratory findings.

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Outcome of fetuses with congenital parvovirus B19 infection: systematic review and meta‐analysis

Abstract: Hydrops is the main determinant of mortality and adverse perinatal outcome in fetuses with PB19 infection. Perinatal outcome in non-hydropic fetuses is generally favorable. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

Cited by 60 publications

References 51 publications

ISUOG Practice Guidelines: role of ultrasound in congenital infection

ISUOG Practice Guidelines: role of ultrasound in congenital infection

The Impact of Maternal Infection on the Neonate

The clinical use of parvovirus B19 assays: recent advances

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