Outcome of Fetuses Diagnosed With Atrioventricular Septal Defect

Partial atrioventricular septal defect in the fetus: diagnostic features and associations in a multicenter series of 30 cases

“…Our data confirm a strong association between pAVSD and chromosomal abonormalities, though to a lesser extent than that shown by complete AVSD3–5. Overall, the 29.1% association rate found in our study is similar to the 34.7% and 24.8% association rates with Down syndrome reported in two large postnatal series9, 10.…”

“…However, although the lesion can be recognized on expert fetal echocardiography, its identification at the obstetric 20‐week anomaly scan is less straightforward, the anomaly showing only a slight alteration of the four‐chamber view. This is why there are no series of fetal pAVSD published to date, the only cases described being in the context of larger collections of fetal cardiac defects2 and/or complete AVSD3–5.…”

Prenatal screening for congenital heart disease with four‐chamber and outflow‐tract views: a multicenter study

“…Congenital heart diseases (CHD) are the most common congenital anomalies, with a prevalence of 3–8 per 1000 live births1–3. Prenatal diagnosis leads to several options: (1) termination of pregnancy, in cases of early diagnosis4; (2) in‐utero treatment, although the only interventions attempted thus far have been balloon valvuloplasty for aortic and pulmonary stenosis5, drainage of pericardial effusion6–10 and creation of an atrial septal defect11, 12; and (3) planning the timing, mode and site of delivery to perform surgery on the neonate in the best possible hemodynamic conditions, thus improving the surgical outcome13–22.…”

Atrioventricular Septal Defect in the Fetus – Associated Conditions and Outcome in 246 Cases

“…Moreover, recent publications are reporting better surgical success rates in infants with Down's syndrome compared to those with a normal karyotype [13]. Nevertheless, previous prenatal AVSD series failed to demonstrate better survival rates of fetuses with Down's syndrome compared to a normal karyotype, primarily due to the limited sample size [14]. We therefore reviewed the experience of our two centers with prenatally diagnosed AVSD over the last 9 years with special attention to the prognostic impact of the different associated conditions, namely Down's syndrome.…”