Outcome of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation and Graft Recovery

Bittner, Hartmuth B.; Lehmann, Sven; Rastan, Ardawan; Garbade, Jens; Binner, Christian; Mohr, Friedrich W.; Barten, M.J.

doi:10.1016/j.athoracsur.2012.05.006

Cited by 53 publications

(35 citation statements)

References 26 publications

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“…[3][4][5][6][7][8][9][10][11][12][13] In the larger reported experiences, success of ECMO as a bridge to LTx varied between 25% and 81%, whereas 1-year survival rates afterward ranged from 60% to 92%. [3][4][5][6][7][8][9][10][11][12][13] With the majority of studies being single-center experiences, ECMO before LTx remains controversial. 14 ECMO before LTx in children is even less established, [15][16][17][18] but a recent study 19 reported that ECMO before LTx in pediatric patients did not negatively impact survival.…”

mentioning

confidence: 87%

Influence of age on survival in adult patients on extracorporeal membrane oxygenation before lung transplantation

Hayes

Whitson

Black

et al. 2015

The Journal of Heart and Lung Transplantation

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mentioning

confidence: 87%

Influence of age on survival in adult patients on extracorporeal membrane oxygenation before lung transplantation

Hayes

Whitson

Black

et al. 2015

The Journal of Heart and Lung Transplantation

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“…12 This time-dependent hazard has also been reported for adult patients supported with extracorporeal devices that survived to 5 years after transplant. 13 Our study duration of 1 year does not allow analysis of such longer-term effects, which could be important if overall longevity of grafts or need for retransplantation is affected by prior VAD support.…”

mentioning

confidence: 99%

Post-transplant Outcomes of Children Bridged to Transplant With the Berlin Heart EXCOR Pediatric Ventricular Assist Device

et al. 2013

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Background— Recent data suggest that Berlin Heart EXCOR Pediatric (EXCOR) ventricular assist device improves waiting list survival for pediatric heart transplant candidates. Little is known about their post-transplant outcomes. The aim of this analysis was to determine whether there was a difference in early survival for children bridged to transplant with EXCOR versus status 1A pediatric heart transplant patients not transplanted with ventricular assist device support. Methods and Results— Pediatric heart transplant patients (n=106) bridged to transplantation with EXCOR were compared with a similarly aged cohort (n=1021) within the Organ Procurement and Transplant Network (OPTN) database (both cohorts from May 2007 to December 2010). In the EXCOR group, 12-month post-transplant survival (88.7%) was similar to OPTN patients listed status 1A who were not on ventricular assist device support at transplant (89.3%; P =0.85) and significantly better than 12-month survival in OPTN patients on extracorporeal membrane oxygenation at transplant (60.3%; P <0.001). Rejection (50%) was a significantly ( P =0.005) higher cause of 12-month post-transplant mortality in the EXCOR compared with the OPTN group. Death after transplant was also higher in EXCOR patients with congenital heart disease compared with those with cardiomyopathy (26.1% versus 7.2%; P =0.02). Post-transplant survival was similar in EXCOR patients with ≥1 serious adverse event during ventricular assist device support as those without an event during support. Conclusions— The 12-month post-transplant survival with EXCOR is comparable with overall pediatric heart transplant survival and superior to survival after extracorporeal membrane oxygenation. Neither adverse events during support nor factors associated with mortality during support influence post-transplant survival. Rejection was a significantly greater cause of post-transplant mortality in EXCOR than in OPTN patients.

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“…A recent case series of 38 ECMO bridges to lung transplant reports an 89% successful bridge (median time 5.5 days) with 1-yr survival of 60% in those actually surviving to transplant [63]. A further recent study showed similarly inferior survival in ECMO bridges to transplant lung recipients [64]. Importantly a 2-4 week time window is required to find a suitable donor.…”

Section: Ecmomentioning

confidence: 99%

Update on lung transplantation: programmes, patients and prospects

Kotsimbos¹,

Williams²,

Anderson³

2012

European Respiratory Review

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Outcome of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation and Graft Recovery

Cited by 53 publications

References 26 publications

Influence of age on survival in adult patients on extracorporeal membrane oxygenation before lung transplantation

Influence of age on survival in adult patients on extracorporeal membrane oxygenation before lung transplantation

Post-transplant Outcomes of Children Bridged to Transplant With the Berlin Heart EXCOR Pediatric Ventricular Assist Device

Update on lung transplantation: programmes, patients and prospects

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