Outcome of Enamel Matrix Derivative Treatment in the Presence of Chronic Stress: Histometric Study in Rats

Corrêa, Mônica Grazieli; Campos, Mirella Lindoso Gomes; Marques, Marcelo Rocha; Ambrosano, Gláucia María Bovi; Casati, Márcio Zaffalon; Nociti, Francisco Humberto; Sallum, Enílson Antônio

doi:10.1902/jop.2013.130383

Cited by 6 publications

(11 citation statements)

References 54 publications

(147 reference statements)

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“… suggested that amelogenin is crucial in enamel formation and biomineralization. In this study, as well as in previous studies of our group , cementum was confined to the margins of the exposed root surface and formed spicules arching toward the wound area, remaining contiguous with the pre‐existing cementum surface. This finding is in agreement with other studies , which showed a limited NCF in this specific model, with or without regenerative treatment.…”

Section: Discussionsupporting

confidence: 82%

“…EMD did not enhanced DF in G2. This result was also observed in a previous study , but differs from the findings of other studies from our group . Nevertheless, the mean values of DF are comparable to those of previous studies and this difference could be attributed to a variation in the biologic healing response among different groups.…”

Section: Discussionsupporting

confidence: 67%

“…Furthermore, a systematic review supports the positive effect of the use of EMD for these periodontal defects . The use of EMD under behavioral and systemic factors has been studied to explore possible interferences in the healing of periodontal tissues . In this context, Corrêa et al .…”

mentioning

confidence: 98%

“…In this context, Corrêa et al . analyzed the influence of cigarette smoke inhalation , diabetes mellitus and stress on the outcome of EMD‐treated fenestration defects in rats.…”

mentioning

confidence: 99%

“…Furthermore, a systematic review supports the positive effect of the use of EMD for these periodontal defects (17). The use of EMD under behavioral and systemic factors has been studied to explore possible interferences in the healing of periodontal tissues (18)(19)(20). In this context, Corrêa et al (18)(19)(20) analyzed the influence of cigarette smoke inhalation (18), diabetes mellitus (19) and stress (20) on the outcome of EMD-treated fenestration defects in rats.…”

mentioning

confidence: 99%

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Alcohol intake may impair bone density and new cementum formation after enamel matrix derivative treatment: histometric study in rats

Corrêa

Campos

Marques

et al. 2015

J of Periodontal Research

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 67%

mentioning

confidence: 98%

“…In this context, Corrêa et al . analyzed the influence of cigarette smoke inhalation , diabetes mellitus and stress on the outcome of EMD‐treated fenestration defects in rats.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Alcohol intake may impair bone density and new cementum formation after enamel matrix derivative treatment: histometric study in rats

Corrêa

Campos

Marques

et al. 2015

J of Periodontal Research

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Aptamers recognizing fibronectin confer improved bioactivity to biomaterials and promote new bone formation in a periodontal defect in rats

Parisi¹,

Rivara²,

Costa³

et al. 2020

Biomed. Mater.

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The use of alloplastic materials in periodontal regenerative therapies is limited by their incapacity to establish a dynamic dialog with the surrounding milieu. The aim of the present study was to control biomaterial surface bioactivity by introducing aptamers to induce the selective adsorption of fibronectin from blood, thus promoting platelets activation in vitro and bone regeneration in vivo. A hyaluronic acid/polyethyleneglycole-based hydrogel was enriched with aptamers selected for recognizing and binding fibronectin. In vitro, the capacity of constructs to support osteoblast adhesion, as well as platelets aggregation and activation was assessed by chemiluminescence within 24 h. Matrices were then evaluated in a rat periodontal defect to assess their regenerative potential by microcomputed tomography (µCT) and their osteogenic capacity by Luminex assay 5, 15 and 30 d postoperatively. Aptamers were found to confer matrices the capacity of sustaining firm cell adhesion (p = 0.0377) and to promote platelets activation (p = 0.0442). In vivo, aptamers promoted new bone formation 30 d post-operatively (p < 0.001) by enhancing osteoblastic lineage commitment maturation. Aptamers are a viable surface modification, which confers alloplastic materials the potential capacity to orchestrate blood clot formation, thus controlling bone healing.

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Dental pulp stem cells

Ashri

Ajlan

Aldahmash

2015

SMJ

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Inflammatory periodontal disease is a major cause of loss of tooth-supporting structures. Novel approaches for regeneration of periodontal apparatus is an area of intensive research. Periodontal tissue engineering implies the use of appropriate regenerative cells, delivered through a suitable scaffold, and guided through signaling molecules. Dental pulp stem cells have been used in an increasing number of studies in dental tissue engineering. Those cells show mesenchymal (stromal) stem cell-like properties including self-renewal and multilineage differentiation potentials, aside from their relative accessibility and pleasant handling properties. The purpose of this article is to review the biological principles of periodontal tissue engineering, along with the challenges facing the development of a consistent and clinically relevant tissue regeneration platform. This article includes an updated review on dental pulp stem cells and their applications in periodontal regeneration, in combination with different scaffolds and growth factors.

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Outcome of Enamel Matrix Derivative Treatment in the Presence of Chronic Stress: Histometric Study in Rats

Abstract: CS may produce a significant detrimental effect on BD. EMD may provide greater DF compared to non-treated control in the presence of CS and increased BD and NCF in the presence or absence of CS.

Cited by 6 publications

References 54 publications

Alcohol intake may impair bone density and new cementum formation after enamel matrix derivative treatment: histometric study in rats

Alcohol intake may impair bone density and new cementum formation after enamel matrix derivative treatment: histometric study in rats

Aptamers recognizing fibronectin confer improved bioactivity to biomaterials and promote new bone formation in a periodontal defect in rats

Dental pulp stem cells

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