Outcome of elderly patients after acute biliary pancreatitis

Roulin, Didier; Girardet, Raphaël; Durán, Rafael; Hajdu, Steven D.; Denys, Alban; Halkic, Nermin; Demartines, Nicolas; Melloul, Emmanuel

doi:10.5582/bst.2017.01303

Cited by 9 publications

(10 citation statements)

References 19 publications

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“…Roulin et al . found that patients aged 70 years and older had a significantly longer hospital stay (median 11 days vs 7 days) than younger patients.…”

Section: Discussionmentioning

confidence: 99%

Outcome of acute pancreatitis in octogenarians: A retrospective study

et al. 2019

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Background and Aim Acute pancreatitis (AP) is a common disease, but data on outcomes in octogenarians are scarce in the literature. The aim of this study is to analyze results from patients aged 80 years old and over who were treated for AP at a single center. Methods Patients aged 80 years and older diagnosed with AP from April 2010 to October 2015 were considered. Demographics, American Society of Anesthesiologists (ASA) score, Charlson Comorbidity Index (CCI), serum biochemistry at 24 and 48 h after admission, and revised Atlanta severity score were analyzed and correlated with hospital mortality rate and length of stay using the multiple regression and Kaplan–Meier tests. Results A total of 100 consecutive patients were included in the study. There were 52 women, and the mean age was 87.5 years (range 80–95). Gallstones were the most common cause of AP (69.7%). The ASA score was ≥III in 51 patients. Eight patients had severe, disease and all of them died in hospital. A CCI > 4 was associated with higher disease severity and mortality (P < 0.00001). The median hospital stay was 9 days (range 1–59). Longer hospital stay was associated with serum C‐reactive protein ≥242 mg/L (P = 0.01) and serum albumin ≤30 g/L (P = 0.01) at 48 h. Over a 5‐year period, 22% of patients were readmitted to hospital with recurrent AP. Gallstones were the main cause of disease (63.6%). Conclusions AP in octogenarians has low mortality. Higher death rate is associated with disease severity. In the presence of gallstone disease, cholecystectomy is recommended whenever possible as the risk of disease recurrence is significant.

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“…Roulin et al . found that patients aged 70 years and older had a significantly longer hospital stay (median 11 days vs 7 days) than younger patients.…”

Section: Discussionmentioning

confidence: 99%

Outcome of acute pancreatitis in octogenarians: A retrospective study

et al. 2019

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“…Among 212 patients with acute biliary pancreatitis, Roulin et al[ 15 ] found similar 90-day mortality rates in the groups with patients <70 and >70 years. Similarly, in the study of Kim et al,[ 18 ] the progression of AP was investigated in patients who were aged <65 and >65 years, and no significant difference was found between the two groups in terms of mortality and complications.…”

Section: Discussionmentioning

confidence: 95%

“…With the increase in the average life expectancy, the number of elderly people is also increasing in societies. [16] Therefore, the course of the disease has been investigated increasingly in the elderly. Previous studies indicate that severe AP is an important cause of morbidity and mortality in elderly patients.…”

Section: Discussionmentioning

confidence: 99%

“…[ 13 ] In some studies, mortality in elderly patients was found to be similar to that in other age groups. [ 14 , 15 ]…”

mentioning

confidence: 99%

“…[13] In some studies, mortality in elderly patients was found to be similar to that in other age groups. [14,15] Physiology and morphology of organs change with age, which is a natural process. Therefore, the response of metabolism to external factors and diseases also change.…”

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Evaluation of laboratory findings and mortality in elderly patients with acute biliary pancreatitis

et al. 2018

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Objectives: Gallstones are the most common cause of acute biliary pancreatitis. Laboratory and imaging findings as well as age are important predictors for mortality. Hospitalization rate is also higher in elderly patients. In this study, we investigated clinical parameters and total mortality in patients with acute pancreatitis aged >65 years. Methods: In this study, 852 patients who entered the Gastroenterology Clinic for acute biliary pancreatitis between April 2006 and October 2013 were included. Data were retrospectively collected from the electronic record system. The patients with elevated aspartate aminotransferase levels (i.e. three times higher than normal value), cholelithiasis, cholecystectomy history, or choledocholithiasis were accepted as the patients with acute biliary pancreatitis. Patients were divided into two groups based on their age, i.e., >65 and <65 years. Results: In the group with patients aged <65 years, serum alanine aminotransferase, albumin, hematocrit, and amylase, and in the group with patients aged >65 years, urea, leukocyte, and C-reactive protein levels were significantly different. Median hospital stay was similar in both the groups. The rate of detection of choledocholithiasis was significantly higher in elderly patients (p<0.001). Mortality rate was significantly higher in elderly patients for 28 day (0.21% and 2.95%, p<0.001) and 90 day (1.25% and 5.63%, p<0.001). In logistic regression multivariate analysis, age (OR 2.0, 95% CI 1.54–1.36; p=0.006), elevated urea levels (OR 1.12, 95% CI 1.05–1.19; p=0.001), elevated hematocrit levels (OR 1.42, 95% CI 1.13–1.77; p=0.002), and decreased albumin levels (OR 0.05, 95% CI 0.004–0.652; p=0.022) were found predictors for 90-day mortality. Conclusion: Laboratory findings in elderly patients with acute pancreatitis may differ from those in younger patients. Although radiological findings are similar in both the groups, mortality is higher in the group with patients aged >65 years.

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Acute Pancreatitis

Pitchumoni

2021

Geriatric Gastroenterology

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Outcome of elderly patients after acute biliary pancreatitis

Cited by 9 publications

References 19 publications

Outcome of acute pancreatitis in octogenarians: A retrospective study

Outcome of acute pancreatitis in octogenarians: A retrospective study

Evaluation of laboratory findings and mortality in elderly patients with acute biliary pancreatitis

Acute Pancreatitis

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