Outcome of domino hematopoietic stem cell transplantation in human subjects: An international case series

Belderbos, Mirjam E.; Gennery, Andrew R.; Dvorak, Christopher C.; Blok, Henric Jan; Eikema, Dirk Jan; Silva, Juliana M.F.; Veys, Paul; Neven, Bénédicte; Buckley, Rebecca H.; Cole, Theresa; Cowan, Morton J.; Goebel, W. Scott; Hoenig, Manfred; Kuo, Caroline Y.; Stiehm, E. Richard; Wynn, Robert; Bierings, Marc

doi:10.1016/j.jaci.2018.06.030

Cited by 1 publication

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These additional risks of unrelated donor transplantation were felt to not outweigh the benefits. Perform a secondary transplant from the first patient once he was two years out from transplant, because he would be expected to have healthy, disease‐free, donor‐derived hematopoietic cells in his blood and marrow. There is uncertainty regarding this option because of the lack of sufficient data for long‐term efficacy of this approach and lack of any reports of such treatment in patients with CGD . In addition, the child had been in a patient role for an extended period of time, and there was concern about adding the additional burden of bone marrow donation to his experience. Do not transplant at all.…”

Section: Clinical Course and Discussionmentioning

confidence: 99%

“…There is uncertainty regarding this option because of the lack of sufficient data for long-term efficacy of this approach and lack of any reports of such treatment in patients with CGD. [20][21][22] In addition, the child had been in a patient role for an extended period of time, and there was concern about adding the additional burden of bone marrow donation to his experience.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Ethical considerations of using a single minor donor for three bone marrow harvests for three HLA‐matched siblings with primary immunodeficiency

Parikh

Pentz

Haight

et al. 2019

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Allogeneic hematopoietic stem cell transplantation is curative for primary immunodeficiencies. Bone marrow from an unaffected human leukocyte antigen (HLA)‐identical sibling donor is the ideal graft source. For minor donors, meaningful consent or assent may not be feasible, and permission from parents or legal guardians is considered acceptable. Adverse events, albeit extremely small, can be associated with bone marrow harvest in pediatric donors. Donor safety concerns potentially increase with multiple bone marrow harvests. Very little is known about multiple bone marrow harvests from pediatric donors. We describe the ethical considerations and clinical decision‐making in an unusual clinical situation where three patients with the same primary immunodeficiency were HLA identical to one another and their younger sibling, who underwent bone marrow harvests three times between 1.3 and 4 years of age, resulting in successful transplantation for all three patients. We hope that this experience will provide guidance to providers and families in a similar situation.

show abstract

Section: Clinical Course and Discussionmentioning

confidence: 99%

mentioning

confidence: 99%