“…Two independent reviewers (S.S.A, H.C) evaluated the risk of bias across the 66 included studies using the Cochrane risk of bias 2 tool [ 53 ]; the results varied. Overall, most of the included studies were assessed to be of some concern (n = 44) [ 19 , 31 , 35 , 58 , 59 , 60 , 61 , 64 , 65 , 67 , 68 , 69 , 70 , 72 , 74 , 75 , 77 , 79 , 80 , 82 , 83 , 87 , 88 , 89 , 91 , 92 , 95 , 96 , 97 , 98 , 100 , 102 , 105 , 106 , 107 , 109 , 110 , 111 , 113 , 114 , 115 , 116 , 117 , 118 , 119 ], 10 studies were evaluated to have an overall high risk, likely due to the risk of bias in randomisation and allocation concealment [ 44 , 50 ,…”