Outcome of conventional IVF and ICSI on sibling oocytes in the case of isolated teratozoospermia

Fan, Wei; Li, Shang wei; Li, Lei; Huang, Zhongying; Ma, Qin; Wang, Yan; Xiao, Zhun

doi:10.1007/s10815-012-9823-x

Cited by 29 publications

(23 citation statements)

References 24 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, according to Lockwood et al [16], teratozoospermia is not a parameter to be taken into account for the choice of ART technique and allows even intra-uterine inseminations. These results confirm those reported by Fan et al [17]. Many other groups also previously demonstrated the absence of effect of isolated teratozoospermia on IVF results [18–21].…”

Section: Discussionsupporting

confidence: 92%

Sperm quality and paternal age: effect on blastocyst formation and pregnancy rates

Chapuis¹,

Gala

Ferrières-Hoa

et al. 2017

Basic Clin. Androl.

View full text Add to dashboard Cite

BackgroundSeveral studies suggest a decrease in sperm quality in men in the last decades. Therefore, the aim of this work was to assess the influence of male factors (sperm quality and paternal age) on the outcomes of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).MethodsThis retrospective study included all couples who underwent IVF or ICSI at Montpellier University Hospital, France, between 1 January 2010 and 31 December 2015. Exclusion criteria were cycles using surgically retrieved sperm or frozen sperm, with pre-implantation genetic diagnosis or using frozen oocytes. The primary outcomes were the blastulation rate (number of blastocysts obtained at day 5 or day 6/number of embryos in prolonged culture at day 3) and the clinical pregnancy rate. The secondary outcomes were the fertilization and early miscarriage rates.ResultsIn total, 859 IVF and 1632 ICSI cycles were included in this study. The fertilization rate after ICSI was affected by oligospermia. Moreover, in ICSI, severe oligospermia (lower than 0.2 million/ml) led to a reduction of the blastulation rate. Reduced rapid progressive motility affected particularly IVF, with a decrease of the fertilization rate and number of embryos at day 2 when progressive motility was lower than 32%.Paternal age also had a negative effect. Although it was difficult to eliminate the bias linked to the woman’s age, pregnancy rate was reduced in IVF and ICSI when the father was older than 51 and the mother older than 37 years.ConclusionsThese results allow adjusting our strategies of fertilization technique and embryo transfer. In the case of severe oligospermia, transfer should be carried out at the cleaved embryo stage (day 2–3) due to the very low blastulation rate. When the man is older than 51 years, couples should be aware of the reduced success rate, especially if the woman is older than 37 years. Finally, promising research avenues should be explored, such as the quantification of free sperm DNA, to optimize the selection of male gametes.

show abstract

Section: Discussionsupporting

confidence: 92%

Sperm quality and paternal age: effect on blastocyst formation and pregnancy rates

Chapuis¹,

Gala

Ferrières-Hoa

et al. 2017

Basic Clin. Androl.

View full text Add to dashboard Cite

show abstract

“…Oocytes randomized to the ICSI group in some studies remained in the "ICSI group" regardless of the ability to perform ICSI [11,21,31]. Other studies included only randomized oocytes that qualified to undergo ICSI to be included in the analysis [19,32].…”

Section: Discussionmentioning

confidence: 99%

“…As early as 1996, Yang et al published the first results of randomly assigned sibling oocytes to either ICSI or CF and demonstrated that similar rates of fertilization and pregnancy occurred in the sample of 13 couples with a total of 280 oocytes [17]. Additional studies have analyzed this approach in patients with a variety of diagnoses and have demonstrated mixed results regarding fertilization, total fertilization failure, morula development, implantation and clinical pregnancy [11,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. The most consistent finding from prior studies is a decrease in the total fertilization failure per IVF cycle in the ICSI groups [11,21].…”

Section: Introductionmentioning

confidence: 99%

Sibling Oocytes Randomly Assigned to Either Conventional Fertilization or Intracytoplasmic Sperm Injection Demonstrate Equivalent Fertilization and Blastulation Rates

Tobler¹,

Brezina²

2014

J IVF Reprod Med Genet

View full text Add to dashboard Cite

Background: To determine the difference in fertilization and blastulation rates between sibling oocytes randomly assigned to either Conventional Fertilization (CF) or Intracytoplasmic Sperm Injection (ICSI) in patient couples with normal semen analysis parameters. Methods:A retrospective review of embryologic and clinical outcomes from patients undergoing their first In Vitro Fertilization (IVF) cycle that randomly assigned one-half of sibling oocytes to either CF or ICSI. Randomization occurred prior to removal of the oocyte cumulus cells which allows identification of metaphase II oocytes eligible for ICSI. All male partners met normal semen analysis parameters and normal fertilization was anticipated for the IVF cycle. Each patient served as their own control.Results: A total of 682 oocytes were included and were assigned to either CF or ICSI. The CF had a significantly higher fertilization rate compared to ICSI (67.9% versus 60%) when immature (non-metaphase II) oocytes were included in the analysis; however this difference diminished when only those oocytes eligible for ICSI were included. There was no difference in the day-3 embryo progression, the blastulation rate, the mean number of oocytes fertilized and the mean number of blastocysts per IVF cycle. Additionally, there was no significant difference in the pregnancy related outcomes between the two groups.Conclusions: These studies demonstrates that in patient couples with normal semen analysis parameters, undergoing their first IVF cycle and who have anticipate normal fertilization, randomly assigning oocytes to CF or ICSI does not improve fertilization or blastulation. To confirm these findings, larger prospective studies are required.

show abstract

“…Another study compared the results after randomization between IVF or ICSI on sibling oocytes in a group of patients with isolated teratozoospermia (<4% strict criteria) ( n = 183) and a group of patients with all normal sperm parameters ( n = 258). They found no significant difference in fertilization rates, day 3 embryonic morphology, pregnancy and spontaneous abortion rates between the groups in either IVF or ICSI (Fan et al ., ).…”

Section: Prognostic Value Of Sperm Morphology Assessment Before Artmentioning

confidence: 97%

Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017

et al. 2017

View full text Add to dashboard Cite

For over 30 years, sperm morphology assessment has been one of the most common tests in evaluation of fertility. This review examines the clinical relevance of sperm morphology assessment in the diagnosis of infertility and in assisted reproductive technology, as well as its analytical reliability. Publications on the pathophysiology, the analytical reliability of the test and its clinical relevance in diagnosis and in Assisted Reproductive Technology (ART) were evaluated. This review compared and discussed study methodologies and results, including patient characteristics, preparation, smear staining methods and classification systems. The assessment of the percentage of some abnormalities such as for example thin head, amorphous head, or bent or asymmetrical neck is of little clinical use, and their pathophysiology is not well explained as most are physiological traits. Some studies have highlighted correlations between the percentage of normal forms and functional sperm abnormalities, as well as correlations with ability to conceive in vivo and, in some situations, with the success of intra-uterine insemination (IUI) or conventional IVF. However, except in the case of some specific sperm defects (easy to detect with 99 or 100% of spermatozoa affected) and which are often linked to genetic disorders (globozoospermia, macrocephaly, decapitated sperm syndrome and fibrous sheath dysplasia), sperm morphology assessment has very poor sensitivity and specificity in the diagnosis of infertility. Moreover, there is very little evidence that indices of multiple sperm defects [sperm deformity index (SDI), teratozoospermia index (TZI), and multiple abnormalities index (MAI)] are relevant. Above all, many publications report a major lack of analytical reliability of this test, mainly in assessment of the details of sperm abnormalities. Many questions arise concerning how and when sperm morphology should be assessed, and how to interpret the thresholds of normal forms. Questions are raised on the real clinical impact of this test.

show abstract

Outcome of conventional IVF and ICSI on sibling oocytes in the case of isolated teratozoospermia

Abstract: Because isolated teratozoospermia did not influence the major indices of IVF and the unnecessary use of ICSI is time-consuming, costly and potential risks, couples with isolated teratozoospermia need not be subjected to ICSI.

Cited by 29 publications

References 24 publications

Sperm quality and paternal age: effect on blastocyst formation and pregnancy rates

Sperm quality and paternal age: effect on blastocyst formation and pregnancy rates

Sibling Oocytes Randomly Assigned to Either Conventional Fertilization or Intracytoplasmic Sperm Injection Demonstrate Equivalent Fertilization and Blastulation Rates

Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017

Contact Info

Product

Resources

About