Outcome of conservative laparoscopic surgery for adnexal torsion through one‐stage or two‐stage operation

Fujishita, Akira; Araki, Hiroyuki; Yoshida, Shiko; Hamaguchi, Daisuke; Nakayama, Daisuke; Tsuda, Nobuo; Khan, Khaleque Newaz

doi:10.1111/jog.12534

Cited by 18 publications

(9 citation statements)

References 13 publications

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“…In these cases, surgical removal of the ovaries is required [4] . Before surgery, painkillers usually are used for pain control [5] . Laparoscopic ovariantorsion surgery generally is used for ovarian detorsion and to restore blood flow to the ovary.…”

Section: Introductionmentioning

confidence: 99%

Ischemia–reperfusion induced injury of rat ovary and the possible protective effect of amlodipine: Histological, immunohistochemial and biochemical study

Bashandy

Khair²

2018

Egyptian Journal of Histology

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Introduction: Ovarian torsion constitutes a gynecologic surgical emergency. However, early diagnosis of torsion may help to detorsion of the affected ovary and to preserve the fertility. Conservative therapy may lead to local and systemic deteriorating effects on the viability of the detorsioned ovary. Aim: The present study was done to evaluate the possible protective effect of amlodipine on ischemia and ischemia reperfusion (I/R) induced ovarian injury in a rat model using histological, immuno-histolochemical, biochemical and morphometric studies. Material and Methods: Forty adult female albino rats were used. They were equally divided into five groups. Group 1: Sham operation (control). Group 2: (ischemia) 3 hours duration of ischemia. Group 3: (ischemia/reperfusion) same as group 2 followed by 3 hours of reperfusion. Group 4: (ischemia and amlodipine) 5 mg amlodipine given orally one hour before ischemia then 3 hours of ischemia. Group 5: (ischemia, re-perfusion and amlodipine) 2 hours of ischemia then 5 mg amlodipine given orally then 3 hours of reperfusion. Then ovarian removal was performed and subjected to histological, immuno-histolochemical , biochemical and morphometric studies. Results: In ischemia and (I/R) groups, the ovaries revealed exfoliation and desquamation of granulosa cells into the follicular cavity of degenerated follicles, with karyolysis and karyorrhexis of the oocyte nucleus, Congested dilated vessels, hyaline degeneration and vacuolation in the interstitial region, Massive cellular infiltrate, hemosiderin deposits and massive hemorrhage of the ovarian stroma. There was positive immunoreactivity for PECAM-I and CD68 and negative for estrogen receptor immunostain. Both superoxide dismutase (SOD) and glutathione (GSH) concentrations were significantly decreased while malondialdehyde MDA (LPO) concentration was significantly increased in ischemia and I/R groups as compared with the other groups. Amlodipine addition improves both histological findings and biochemical values Conclusion: Amlodipine attenuates ischemia and (I/R) induced ovarian tissue injury

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Section: Introductionmentioning

confidence: 99%

Ischemia–reperfusion induced injury of rat ovary and the possible protective effect of amlodipine: Histological, immunohistochemial and biochemical study

Bashandy

Khair²

2018

Egyptian Journal of Histology

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“…Laparoscopic ovarian-torsion surgery generally is used for ovarian detorsion and to restore blood flow to the ovary. Before surgery, painkillers usually are used for pain control (Fujishita et al, 2015). In neglected or prolonged cases, necrosis develops in ovarian tissue to which blood flow has been cut for a long time.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary

et al. 2017

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GÖRKEM, Ü.; TOGRUL, C.; SAHIN, I.; COSKUN, B.; OZAT, M.; GÜNGÖR, T. & DEVECI, E.Protective effect of caffeic acid phenethyl ester (cape) on ıschemia-reperfusion ınjury in rat ovary. Int. J. Morphol. 35(1):141-147, 2017. SUMMARY:The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. A total of 28 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR + CAPE. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and Cape groups (P<0.005). The detorsion group showed preantral ovarian follicles and luteal folicules around the blood vessels and positive expression of CD34. In the CAPE group the stromal vascular endothelium with weak expression of CD34 was detected in small areas, and the ovarian follicles and the corpus luteum showed negative expression of CD34. In the study, Biochemical and histopathological results of CAPE treatment was considered to torsion-detorsioned the model showed a protective effect against tissue damage.

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“…Ovarian torsion has been as reported as the fifth leading cause of gynecologic emergencies. 1,2 Ovarian torsion increases five-fold during pregnancy. Torsion of ovarian tumors occurs predominantly in the reproductive age group.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Fallopian tube may also be involved (adnexal torsion). The predisposing factors are moderate-to-large cyst size, free mobility, and long CaSe RepoRt 1 Resident, 2 Lecturer, 3 Professor and Head …”

Section: Introductionmentioning

confidence: 99%

Torsion of Ovarian Cyst presenting as Acute Abdomen: Report of Two Cases

Singh¹,

Kamble²

2017

MGM Journal of Medical Sciences

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Introduction: Two cases of ovarian cyst torsion are presented. The first case was a young girl, 17 years of age, who presented with acute abdomen. Ultrasonography (USG), computed tomography (CT) scan, and Doppler revealed bilateral ovarian cysts. The right-sided cyst had undergone torsion. Exploratory laparotomy confirmed the presence of twisted ovarian cyst on right side and a small dermoid cyst on left side. Right side salpingo-oophorectomy and left side cystectomy were done. The patient made an uneventful recovery.The second case was a 27-year-old lady, primigravida with 8-week pregnancy, who came with severe pain in right lower quadrant of abdomen of 3 days duration. Ultrasonography was suggestive of live intrauterine pregnancy of 8.4 weeks gestation and two cysts in the right ovary. The Doppler scan for the cyst was suggestive of ovarian torsion. Laparotomy confirmed the diagnosis of ovarian torsion. Right-sided salpingo-oophorectomy was carried out. The patient made an uneventful recovery and she is continuing with pregnancy.

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Outcome of conservative laparoscopic surgery for adnexal torsion through one‐stage or two‐stage operation

Cited by 18 publications

References 13 publications

Ischemia–reperfusion induced injury of rat ovary and the possible protective effect of amlodipine: Histological, immunohistochemial and biochemical study

Ischemia–reperfusion induced injury of rat ovary and the possible protective effect of amlodipine: Histological, immunohistochemial and biochemical study

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary

Torsion of Ovarian Cyst presenting as Acute Abdomen: Report of Two Cases

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Outcome of conservative laparoscopic surgery for adnexal torsion through one‐stage or two‐stage operation

Cited by 18 publications

References 13 publications

Ischemia–reperfusion induced injury of rat ovary and the possible protective effect of amlodipine: Histological, immunohistochemial and biochemical study

Ischemia–reperfusion induced injury of rat ovary and the possible protective effect of amlodipine: Histological, immunohistochemial and biochemical study

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Ischemia­Reperfusion Injury in Rat Ovary

Torsion of Ovarian Cyst presenting as Acute Abdomen: Report of Two Cases

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Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary