Outcome of asthma induced by isocyanates

Lozewicz, S.; Assoufi, B; Hawkins, R; Taylor, A J Newman

doi:10.1016/0007-0971(87)90103-3

Cited by 74 publications

(39 citation statements)

References 6 publications

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“…The outcome of isocyanateinduced asthma has been investigated previously [3][4][5][6][7][8][9][10][11]. However, this study offers additional interest.…”

Section: Discussionmentioning

confidence: 96%

“…In terms of long-term outcome, despite complete avoidance of exposure, PARK and NAHM [3] showed a spectrum of responses in subjects with isocyanate asthma and proposed that the final outcome depends on which mechanism is predominant in each individual. The majority of the follow-up studies on isocyanate asthma [4][5][6][7][8][9][10][11] emphasised that only one-half of subjects with isocyanate asthma will recover, while one-half of those who do not recover will show some improvement, and one-half will complain of asthmatic symptoms and will require anti-asthma therapy. Short duration of exposure to isocyanates and of symptoms before the diagnosis, immediate cessation of exposure after diagnosis, young age, milder degree of nonspecific airway hyperresponsiveness and presence of specific immunoglobulin (Ig)E antibodies to isocyanates have been found to be associated with a favourable prognosis.…”

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confidence: 99%

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Long-term follow-up of toluene diisocyanate-induced asthma

Padoan¹,

Pozzato²,

Simoni³

et al. 2003

Eur Respir J

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Eighty-seven cases of occupational asthma induced by toluene diisocyanate (TDI) were diagnosed by an inhalation challenge with TDI and methacholine. After an average follow-up interval of 11 yrs, all subjects were re-examined.Of the 87 subjects examined, 13 (15%) had remained in the same job, 44 (50.5%) had been removed from exposure forv10 yrs and 30 (34.5%) had been removed forw10 yrs. The proportion of subjects who experienced symptoms of asthma and those who were hyperresponsive to methacholine was significantly lower. Of the patients, 59% used short-acting bronchodilators, 8% long-acting bronchodilators and 18% were on regular inhaled glucocorticoids. Thus, multiple regression analysis showed a positive correlation between forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) at follow-up and FVC and FEV1 at diagnosis, and a negative correlation with smoking and with therapy with bronchodilators. Stepwise logistic regression showed that the follow-up provocative dose causing a 20% fall in the FEV1 (PD20) could be predicted from baseline PD20.These results indicate that respiratory symptoms and airway hyperresponsiveness to methacholine persist in subjects removed from exposure to TDI for w10 yrs. A more favourable prognosis was associated with a better lung function and a lower degree of airway hyperresponsiveness to methacholine at diagnosis. Eur Respir J 2003; 21: 637-640.

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“…The outcome of isocyanateinduced asthma has been investigated previously [3][4][5][6][7][8][9][10][11]. However, this study offers additional interest.…”

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Long-term follow-up of toluene diisocyanate-induced asthma

Padoan¹,

Pozzato²,

Simoni³

et al. 2003

Eur Respir J

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“…In a follow-up study of 50 workers with isocyanate-induced asthma, all of whom had avoided isocyanate exposure for at least 4 years, 82% continued to have respiratory symptoms and approximately half of these required inhaled or oral medications for asthma at least once per week. (20) Death has been reported in an isocyanate-sensitized worker who continued to work with polyurethane paint containing isocyanates. (21) Evaluation criteria are used as guidelines to assess the potential health effects of occupational exposures to substances and conditions found in the work environment.…”

Section: Evaluation Criteria Isocyanatesmentioning

confidence: 99%

Health hazard evaluation report: HETA-94-0265-2703, J. L. Long Middle School, Dallas, Texas.

1998

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“…In a follow-up study of 50 workers with isocyanate-induced asthma, all of whom had avoided isocyanate exposure for at least four years, 82% continued to have respiratory symptoms, and approximately half of these required inhaled or oral medications for asthma at least once per week. (28) Death from occupational asthma has been reported in an isocyanatesensitized worker who continued to work with polyurethane paint containing isocyanates. (29) The percentage of workers with isocyanate induced asthma who have persistent symptoms of asthma years after discontinuing occupational exposure may be 50% or higher.…”

Section: Page 9 -Health Hazard Evaluation Report No 93-0436mentioning

confidence: 99%

Health hazard evaluation report: HETA-93-0436-2569, Trus Joist MacMillan, Deerwood, Minnesota.

1996

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This Health Hazard Evaluation (HHE) report and any recommendations made herein are for the specific facility evaluated and may not be universally applicable. Any recommendations made are not to be considered as final statements of NIOSH policy or of any agency or individual involved.Additional HHE reports are available at http://www.cdc.gov/niosh/hhe/reports This Health Hazard Evaluation (HHE) report and any recommendations made herein are for the specific facility evaluated and may not be universally applicable. Any recommendations made are not to be considered as final statements of NIOSH policy or of any agency or individual involved.Additional HHE reports are available at http://www.cdc.gov/niosh/hhe/reports This Health Hazard Evaluation (HHE) report and any recommendations made herein are for the specific facility evaluated and may not be universally applicable. Any recommendations made are not to be considered as final statements of NIOSH policy or of any agency or individual involved. applicable. Any recommendations made are not to be considered as final statements of NIOSH policy or of any agency or individual involved.Additional HHE reports are available at http://www.cdc.gov/niosh/hhe/reports

show abstract

Outcome of asthma induced by isocyanates

Cited by 74 publications

References 6 publications

Long-term follow-up of toluene diisocyanate-induced asthma

Long-term follow-up of toluene diisocyanate-induced asthma

Health hazard evaluation report: HETA-94-0265-2703, J. L. Long Middle School, Dallas, Texas.

Health hazard evaluation report: HETA-93-0436-2569, Trus Joist MacMillan, Deerwood, Minnesota.

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