Outcome of Appendicectomies at Surgery for Mucinous Ovarian Neoplasms: Report From A UK Center and Review of Literature

Mukhopadhyay, Debjani; Rajab, Ramzi; Nobbenhuis, Mariëlle; Dilley, James; Heath, Owen; Wang, Jayson; Ind, Thomas; Barton, Desmond P.J.

doi:10.1097/igc.0000000000000719

Cited by 12 publications

(3 citation statements)

References 19 publications

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“…The authors concluded that normal-looking appendix could be left in situ in case of ovarian mucinous adenocarcinoma. 10 Although routine appendectomy could be related to postoperative complication, 2 studies did not find an increased number of complications after 40 and 155 cases of appendectomy, respectively. 8,9 In additional 121 cases of routine prophylactic appendectomy during laparoscopic hysterectomy for benign conditions, Wang et al 11 did not experience an increase in postoperative complications.…”

Section: Figurementioning

confidence: 98%

The Importance of Appendectomy in Surgery for Mucinous Adenocarcinoma of the Ovary

Rosendahl¹,

Oester

Høgdall

2017

International Journal of Gynecological Cancer

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Section: Figurementioning

confidence: 98%

The Importance of Appendectomy in Surgery for Mucinous Adenocarcinoma of the Ovary

Rosendahl¹,

Oester

Høgdall

2017

International Journal of Gynecological Cancer

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“…However, if the appendix is grossly normal, which is the case for this patient, performing an appendicectomy as part of the surgical staging procedure seems not to be necessary. [30] Whether or not our surgical procedure is a better option will be eventually determined by the patient's survival period.…”

Section: Discussionmentioning

confidence: 99%

Colonic mucinous adenocarcinoma causing intussusception and distant metastasis

Xu¹,

Kong²,

Yi³

et al. 2019

Medicine

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Rationale: Cases of intussusception caused by mucinous carcinoma have been rarely reported, and those caused by colonic mucinous adenocarcinoma (MAC) with distant metastasis were even fewer. Patient concerns: A 60-year-old woman who complained of severe pain around the navel with nausea and vomiting for a week was admitted on November 28, 2017. There were multiple watery stools and abdominal pain was worsened over the prior week. Diagnosis: She was diagnosed by abdominal computed tomography, current medical history, and abdominal signs. Her initial diagnosis was acute abdomen, intussusceptions, and intestinal obstruction. The final diagnosis was MAC, which was based on postoperative pathology. Interventions: The patient received emergency laparotomy, followed by 5 courses of chemotherapy with oxaliplatin plus capecitabine, and then 6 courses with 5-fluorouracil + oxaliplatin + calcium leucovorin. Outcomes: The patient was in good nutritional condition, and no obvious tumor recurrence or metastasis was found until July 9, 2018. Lessons: Even though the prognosis of colonic MAC is poor, being able to receive timely surgical treatment, good nutritional status and reasonable postoperative chemotherapy are the key factors to prolonging patient's survival.

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“…While appendicectomy is commonly performed in the staging of MBOT, data from several studies do not support this practice in the presence of a macroscopically normal appendix. 23,24 Intraoperative frozen section, not utilized in this cohort as this service was not routinely available throughout this …”

Section: Discussionmentioning

confidence: 99%

Borderline Ovarian Tumors: Fifteen Years’ Experience at a Scottish Tertiary Cancer Center

May

Skorupskaite

Congiu

et al. 2018

Int J Gynecol Cancer

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ObjectivesSince the recognition of borderline ovarian tumors (BOTs) in the 1970s, the management of this subset of epithelial ovarian tumors has presented a challenge to clinicians. The majority present at an early stage, but their diagnosis is often only made following surgery, hence the heterogeneity of surgical management. Borderline ovarian tumors are morphologically diverse, and their behavior is subsequently also heterogeneous. We aimed to assess recurrence rates and the rate of malignant transformation in patients diagnosed with BOT. Secondary objectives included a review of current management and assessment of tumor markers, stage, cyst dimensions, and the presence of micropapillary features as prognostic indicators of recurrence.MethodsThis retrospective cohort study included all patients treated with BOT between 2000 and 2015 in the southeast region of Scotland. Clinical, surgicopathological, and follow-up data were collated. Data were analyzed with reference to recurrence and malignant transformation.ResultsTwo hundred seventy-five patients underwent treatment for BOT in the study period. Surgical management was highly variable. A diagnosis of recurrent/persistent BOT or ovarian malignancy following initial treatment of BOT was rare, with only 12 (4%) of 275 cases. There were 7 cases (3%) of ovarian malignancy. Advanced International Federation of Gynecology and Obstetrics stage was the most prominent prognostic factor. Elevated preoperative serum CA-125 and the presence of micropapillary features correlated with advanced stage at presentation. With a lack of clear guidance, follow-up was highly variable with a median of 43 months (0–136 months).ConclusionsTo our knowledge, this study is the largest BOT cohort in the United Kingdom. Recurrent disease is rare in optimally staged, completely resected, early-stage BOT, without high-risk features. Caution is needed in women electing not to undergo completion staging after diagnosis and in those opting for a fertility-preserving approach. Thorough informed consent and clear plans for surveillance and follow-up are needed with consideration of delayed completion surgery as appropriate.

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Outcome of Appendicectomies at Surgery for Mucinous Ovarian Neoplasms: Report From A UK Center and Review of Literature

Abstract: In MOT, an abnormal appearing appendix should be excised. If the appendix is grossly normal, our data do not support performing an appendicectomy as part of a surgical staging procedure.

Cited by 12 publications

References 19 publications

The Importance of Appendectomy in Surgery for Mucinous Adenocarcinoma of the Ovary

The Importance of Appendectomy in Surgery for Mucinous Adenocarcinoma of the Ovary

Colonic mucinous adenocarcinoma causing intussusception and distant metastasis

Borderline Ovarian Tumors: Fifteen Years’ Experience at a Scottish Tertiary Cancer Center

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