Outcome of anorexia nervosa: Eating attitudes, personality, and parental bonding

Bulik, Cynthia M.; Sullivan, Patrick F.; Fear, Jennifer L.; Pickering, Alison

doi:10.1002/1098-108x(200009)28:2<139::aid-eat2>3.3.co;2-7

Cited by 21 publications

(29 citation statements)

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“…[14][15][16] A strong relationship between ED and some personality traits has been described. [24][25][26] We report here that BN patients carrying the NTRK2 high-risk haplotype C-A-insC display high scores in Harm 27,28 These results support the involvement of NTRK2 in the development of ED, not only through a direct participation in food intake and body weight regulation, as suggested by animal models, but also through the modulation of different personality traits that may increase the risk of AN and BN, such as depression or anxiety.…”

Section: Ntrk2 and Eating Disorders M Ribases Et Alsupporting

confidence: 81%

Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index

et al. 2005

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Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders (ED) with complex genetic and environmental components. Genetic studies and animal models support the participation of brain-derived neurotrophic factor (BDNF) in the vulnerability to AN and BN. We investigated the genetic contribution of the BDNF-specific receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) to the susceptibility to ED. We have screened the entire NTRK2 gene in 91 patients with ED and have identified 14 single-nucleotide polymorphisms (SNPs). A population-based association study with six SNPs from the NTRK2 locus was performed in 164 ED patients and 121 controls. Significant evidence of association for markers -69C4G and IVS13 þ 40G4A was detected. We also observed a strong association between the C-A-insC haplotype (-69/IVS13 þ 40/2784-2785) and binge-eating/purging AN (ANP, P ¼ 0.006; OR ¼ 2.27), and a reduced frequency of haplotype G-A-delCl in BN patients (P ¼ 0.034; OR ¼ 0.6). The analysis of ED-related phenotypes revealed a clear association between NTRK2, high scores of Harm avoidance measured by the temperament and character inventory (TCI-R; P ¼ 0.003) and minimum body mass index (minBMI; Po0.001). Our data support a contribution of NTRK2 to the genetic susceptibility of ED, mainly ANP, and ED-related phenotypic traits, such as Harm avoidance and minBMI. Keywords: anorexia; bulimia; eating disorders; harm avoidance; BDNF; NTRK2 Eating disorders (ED) are complex psychiatric diseases characterized by alterations in eating behaviour, body shape perception and body weight regulation. Different genetic, psychological and environmental factors contribute to the vulnerability to both anorexia nervosa (AN) and bulimia nervosa (BN), but the pathophysiology of these disorders is still largely unknown. 1 Brain-derived neurotrophic factor (BDNF) encodes for a neurotrophic factor expressed in the hypothalamic nuclei that regulate eating behaviour and modulates synaptic efficiency and neuronal plasticity through the control of different neurotransmitter systems previously involved in ED.2,3 Intraventricular administration of Bdnf induces appetite suppression and body weight reduction in rats, while Bdnf knockout mice develop obesity associated to hyperphagia and serotonin dysfunctions.3-5 Moreover, we and others have previously reported a strong association between BDNF and both AN and BN in different populations. [6][7][8][9] Due to the strong association between BDNF and ED, we propose its high-affinity receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) as a candidate gene to participate in the aetiology of ED and suggest that alterations on its function or expression pattern could contribute to the development of AN and BN. Different lines of evidences support this hypothesis. NTRK2 is expressed in hypothalamic neurons that control food intake and energy expenditure. Infusion of the Ntrk2 specific ligands, Bdnf or Nt4/5, transiently reverse the eating behaviour and obesity of the Bdnf (7) knockout mice and the ...

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Section: Ntrk2 and Eating Disorders M Ribases Et Alsupporting

confidence: 81%

Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index

et al. 2005

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“…Personality factors such as high levels of negative emotionality, obsessionality, neuroticism, harm avoidance, perfectionism and low self-esteem are also viewed as important aetiological factors (Bulik, Sullivan, Fear, & Pickering, 2000;Bulik et al, 2003;Halmi et al, 2003;Holliday, Uher, Landau, Collier, & Treasure, 2006). In a population-based cohort of Swedish twins, Bulik and colleagues found that neuroticism emerged as the only prospective predictor of AN (Bulik et al, 2006).…”

Section: Aetiology Of Anorexia Nervosamentioning

confidence: 99%

The Concept of Body Image Disturbance in Anorexia Nervosa: An Empirical Inquiry Utilizing Patients' Subjective Experiences

et al. 2011

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“…[27][28][29] Others have focused on the resolution of core AN symptoms such as fear of becoming fat, drive for thinness, body image disturbance, or presence of the diagnosis. [30][31][32][33][34] A number of researchers have suggested that a more multidimensional biopsychosocial view of recovery be examined to fully understand the overall effectiveness of treatment and the impact of disease on the patient's life. 9,25,26,35 A small number of studies have taken multidimensional views of AN outcomes.…”

Section: Outcomes Of Anorexia Nervosamentioning

confidence: 99%

Readiness for change and short‐term outcomes of female adolescents in residential treatment for anorexia nervosa

McHugh

2007

Intl J Eating Disorders

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Objective: To determine if readiness for change (RFC) at admission predicted length of stay (LOS) and short-term outcomes among female adolescents in residential treatment for anorexia nervosa (AN).Method: Using a prospective cohort design to collect data from participants (N 5 65) at admission and discharge, KaplanMeier survival analysis and Cox regression tested whether RFC on admission predicted time in LOS to a favorable short-term outcome-a composite endpoint based on minimum criteria for weight gain, drive for thinness, depression, anxiety, and healthrelated quality of life (HRQOL).Results: Participants with low RFC had a mean survival time to a favorable short-term outcome of 59.4 days compared to 34.1 days for those with high RFC (log rank 5 8.44, df 5 1, p 5 .003). The probability of a favorable short-term outcome was 5.30 times greater for participants with high RFC. Conclusion:Readiness for change is a useful predictor of a favorable short-term outcome and should be considered in the assessment profile of patients with AN. V V C 2007 by Wiley Periodicals, Inc.

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Outcome of anorexia nervosa: Eating attitudes, personality, and parental bonding

Cited by 21 publications

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Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index

Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index

The Concept of Body Image Disturbance in Anorexia Nervosa: An Empirical Inquiry Utilizing Patients' Subjective Experiences

Readiness for change and short‐term outcomes of female adolescents in residential treatment for anorexia nervosa

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