Outcome of adult onset systemic lupus erythematosus in Iran

Fatemi, Alimohammad; Matinfar, Mohammad; Sayedbonakdar, Zahra; Maracy, Mohammad Reza; Karimzadeh, Hadi; Saber, Mina; Smiley, Abbas

doi:10.1177/0961203314534304

Cited by 9 publications

(5 citation statements)

References 38 publications

(61 reference statements)

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Section: Resultsmentioning

confidence: 99%

“…Similar studies in other regions (Americas, Europe and Asia) estimate that approximately 40% of patients with SLE develop LN, 3 whilst two separate Iranian studies estimate that 29% and 67% of patients with SLE have LN. 33,34 Treatment practices and procedures in the Arabian Gulf region Treatment recommendations. Several treatment recommendations for LN have been published, including APLAR, EULAR and KDIGO.…”

Section: Incidence and Prevalence Of Ln In The Arabian Gulf Regionmentioning

confidence: 99%

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Literature review of lupus nephritis From the Arabian Gulf region

Al-Shujairi

Elbadawi

Al-Saleh

et al. 2022

Lupus

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Introduction The severity of lupus nephritis (LN) varies between different ethnicities. However, there are limited data regarding disease severity for LN in patients from the Arabian Gulf region; moreover, there are no treatment guidelines developed specifically for this population. The objective of this review was to characterise the incidence of LN, current treatment practices, the severity of LN, and the pathophysiology and biomarkers associated with LN in the Arabian Gulf region. Methods A literature search using EMBASE was conducted in October, 2021 to identify publications reporting on the incidence, treatment practices, severity, pathophysiology or biomarkers associated with LN, from countries in the Arabian Gulf region (including Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and the United Arab Emirates). Additional relevant publications were provided by collaborators. A manual review of the publications was conducted to determine their relevance and data on the outcomes of interest were extracted. Results Of 3705 publications, 54 publications were identified as relevant. LN is one of the most commonly diagnosed renal diseases within the Arabian Gulf and approximately 10%–36% of all renal biopsies are for LN. Treatment patterns within the region appear to vary and generally follow treatment guidelines recommended by the Asia Pacific League of Associations for Rheumatology (APLAR), the European Alliance of Associations for Rheumatology (EULAR) and Kidney Disease Improving Global Outcomes (KDIGO). The majority of patients receive cyclophosphamide for induction therapy, whilst others receive mycophenolate mofetil. Most studies showed that the most frequently diagnosed class of LN within the Arabian Gulf region was Class IV (up to 63% of patients with LN). Sustained or increased levels of serum creatinine and proteinuria; and depressed levels of complement C3/C4 were commonly seen among patients with LN from the Arabian Gulf region. Conclusions This review identified that LN may manifest more severely among patients from the Arabian Gulf region than in other populations, such as Caucasian populations. A greater understanding of LN and the treatment practices within the region, as well as the development of more specific treatment guidelines for this population may help improve outcomes for patients with LN in the Arabian Gulf region.

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Section: Resultsmentioning

confidence: 99%

Section: Incidence and Prevalence Of Ln In The Arabian Gulf Regionmentioning

confidence: 99%

Literature review of lupus nephritis From the Arabian Gulf region

Al-Shujairi

Elbadawi

Al-Saleh

et al. 2022

Lupus

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“…[4] Whereas pericarditis is most common in SLE patients and it has been associated with poor survival. [5] Almost 25% of patients with SLE develop symptomatic pericarditis at some stage of the disease, most often accompany with pleuritis. [6,7] More than 30% of patients are found to have pericardial involvement by imaging examinations.…”

Section: Discussionmentioning

confidence: 99%

Cardiac tamponade as the initial symptom due to systemic lupus erythematosus in a young man

Zhang¹,

Wu²

2018

Medicine

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Rationale:Systemic lupus erythematosus (SLE) is a connective tissue disease that has many clinical manifestations. However, cardiac tamponade has been rarely reported especially as an initial presenting feature of systemic lupus erythematosus. Herein, we describe a case of cardiac tamponade as the first presentation of systemic lupus erythematosus in a male and presented the course of diagnosis and treatment of this patient.Patient concerns:A 32-year-old male patient developed a rapid progression of pericardial effusion and he was almost healthy in the past. Vital signs were significantly marked by high fever, tachycardia, and accelerated breathing rate of 37 times per minute. The ANA titer was 1:320 and anti-dsDNA was positive during his hospitalization. The complement levels were decreased but the ESR and the CRP level were increased obviously. Soon after, he appeared anemic and thrombocytopenic.Diagnoses:The diagnosis of SLE was made based on the clinical and biochemical findings according to 2012 SLICC SLE Criteria.Interventions:The interventions included use CT-guided pericardial puncture to relieve symptoms in time; utilize high-dose glucocorticoids and immunosuppressants to therapy SLE; closely monitor the vital signs, blood routine, blood biochemical indicators, and volume of pericardial effusion.Outcomes:After 2 months, the symptoms were disappeared almost completely and TTE showed his pericardial effusion had decreased significantly.Lessons:We should also keep SLE in mind when assessing male patients with pericardial effusions. Early examinations of sero-immunological markers and closely monitoring the performances are important for the diagnosis of the disease. Early pericardial puncture can quickly relieve symptoms and improve prognosis.

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“…По данным португальского регистра больных СКВ, серьезные органные поврежде-ния были зарегистрированы со стороны нервно-психи-ческой сферы, органов зрения, опорно-двигательного аппарата [35]. Предикторами неблагоприятного исхода у иранских пациентов были высокая активность СКВ, сердечно-сосудистые осложнения и инфекции [36]. Вы-сокую частоту летальных исходов в киргизской когорте больных СКВ можно объяснить также и тем, что боль-шинство населения республики проживает в сельской местности, где социально-экономический уровень жите-лей достаточно низкий, а квалифицированная медицин-ская помощь находится не на высоком уровне, что не по-зволяет своевременно диагностировать СКВ по клиниче-ским и лабораторным критериям.…”

Section: Discussionunclassified