Outcome of a phase II prospective study on partial breast irradiation with interstitial multi-catheter high-dose-rate brachytherapy

Aristei, Cynthia; Palumbo, Isabella; Capezzali, G.; Farneti, Alessia; Bini, Vittorio; Falcinelli, Lorenzo; Margaritelli, Manuela; Lancellotta, Valentina; Zucchetti, C.; Perrucci, Elisabetta

doi:10.1016/j.radonc.2013.08.005

Cited by 17 publications

(9 citation statements)

References 43 publications

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“…Hence, intensity modulated radiation therapy (IMRT), proton beam irradiation, prone positioning and breath hold are recommended to reduce heart absorbed dose. [31,32] In addition, partial breast irradiation as an alternative to whole irradiation after breast conserving surgery in selected patients, [33] may reduce dose to the heart in those with left breast cancer. [34] And their effects on BNP need further exploring.…”

Section: Discussionmentioning

confidence: 99%

BNP as a potential biomarker for cardiac damage of breast cancer after radiotherapy: a meta-analysis

Zhang

Shi²,

Yang

2019

Medicine

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Background: To analyze whether BNP could be a potential biomarker for cardiac damage of breast cancer after radiotherapy. Methods: PubMed, Web of Science, ProQuest and Medline were searched using the key words “breast cancer” (“breast tumor”, “breast neoplasm”, or “breast carcinoma”), “brain natriuretic peptide” (or BNP) and “radiotherapy” (or “radiation therapy”). Four articles were selected and analyzed using the STATA 12.0 software package. The standard mean difference (SMD) and its standard error for BNP were calculated to assess the relationship between BNP and radiotherapy for breast cancer patients. Results: In total, 172 patients with breast cancer were identified. The pooled SMD was -0.233 (95% CI −1.113, −0.057). The pooled estimated SMD for all studies showed obvious significant difference (z = 3.99, P = .000). There was no publication bias. Conclusions: This meta-analysis suggested that BNP could be a biomarker of cardiac damage at high heart absorbed doses according to radiotherapy, especially for left breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

BNP as a potential biomarker for cardiac damage of breast cancer after radiotherapy: a meta-analysis

Zhang

Shi²,

Yang

2019

Medicine

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“…Inclusion criteria, according to the Groupe Européen de Curiethérapie and the European Society for Radiotherapy & Oncology (GEC-ESTRO) recommendations on patient selection for APBI of low and intermediate risk groups were as follows: age ≥ 40 years, tumor size by final pathology ≤ 3 cm, negative axillary lymph nodes (sentinel or dissection), microscopically negative or close (≤ 2 mm) surgical margins, invasive ductal or lobular carcinoma, unicentric/unifocal tumors. Exclusion criteria consisted of younger age, tumors more than 3 cm in size, positive margins (presence of tumor tissue on surgical margins), axillary lymph nodes’ metastasis, presence of extensive intraductal component, multicentric/multifocal tumors [24, 25, 26, 27, 28]. All patients have signed informed consent before the treatment.…”

Section: Methodsmentioning

confidence: 99%

“…There is a number of publications available about high-dose-rate interstitial APBI, but in the majority of them, different dose fractionation was used: from 10 to 7 fractions by 3.4 Gy to 5.2 Gy [19, 21, 22, 23, 24]. We started APBI as treatment option for early breast cancer in 2012, after institutional review board approved treatment protocol.…”

Section: Purposementioning

confidence: 99%

High-dose-rate interstitial brachytherapy for accelerated partial breast irradiation – trial results of Azerbaijan National Center of Oncology

Aliyev¹,

Isayev²,

Akbarov³

et al. 2017

jcb

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PurposeTo describe early results of two cohorts of patients with low and intermediate risk of early breast cancer treated with accelerated partial breast irradiation (APBI) using different schedules of multicatheter brachytherapy.Material and methodsPatients with early stage breast cancer after breast conserving surgery were enrolled for a prospective analysis. The APBI, using multicatheter brachytherapy, was delivered either eight times 4 Gy in five days with a planned total dose of 32 Gy, or seven times 5 Gy in four days with a planned total dose of 35 Gy. Primary endpoints were side effects.ResultsForty-eight patients were enrolled between 2012 and 2014. Patients characteristics were as follow: median age of patients was 55 years, early breast cancer was defined according GEC-ESTRO recommendations. With a median follow-up period of 37 months, no significant differences regarding late side effects and cosmesis between two cohorts of patients were documented. In total, cosmesis was excellent in 13/48 (27.1%) patients, good in 34/48 (70.8%) patients, and moderate in 1/48 patient (2.1%).ConclusionsAccelerated partial breast irradiation using multicatheter brachytherapy with 32 Gy/8 fractions and 35 Gy/7 fractions for early breast cancer seems to be similar in terms of late side effects. According to our findings, APBI was also feasible for intermediate-risk of early breast cancer patients.

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“…In BC, radiationassociated side effects include cardiac and skin toxicities, fibrosis, lymphedema, secondary cancers, rib fractures and brachial plexopathy (139). In some studies the combination of tamoxifen and RT has resulted in an increased risk of fibrosis, hypothesized to be due to a tamoxifen-induced increase in TGF-β (140)(141)(142)(143)(144). Even with highly conformal intensitymodulated RT and image-guided RT, which aim to spare regional organs from radiation exposure, these side effects can occur in up to 15% of patients and can seriously affect patients' physiological and physical quality of life (145,146).…”

Section: Biomarkers Of Radiation-induced Toxicitymentioning

confidence: 99%

Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer

et al. 2020

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Outcome of a phase II prospective study on partial breast irradiation with interstitial multi-catheter high-dose-rate brachytherapy

Cited by 17 publications

References 43 publications

BNP as a potential biomarker for cardiac damage of breast cancer after radiotherapy: a meta-analysis

BNP as a potential biomarker for cardiac damage of breast cancer after radiotherapy: a meta-analysis

High-dose-rate interstitial brachytherapy for accelerated partial breast irradiation – trial results of Azerbaijan National Center of Oncology

Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer

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