Outcome of a dog undergoing definitive‐intent intensity‐modulated radiation therapy for an intranasal ganglioneuroma

Abstract

An 11‐year‐old intact male Shiloh Shepherd was presented for evaluation of epistaxis, decreased nasal airflow, and destructive caudal nasal lesion identified using CT. Histopathologic evaluation of the nasal mass was consistent with a ganglioneuroma. The dog was treated with 10 × 4.2 Gy using IMRT technique. Post radiation therapy (RT), improvement in clinical signs were noted. Tumor progressed in size based on CT evaluation at 49 days, 3, and 6 months post‐treatment. A grade 2 oral mucositis was the only RT side effect noted. Radiation therapy as described above was completed without evidence of high‐grade radiation toxicities and has potential to improve clinical signs but failed to induce tumor response.

Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases

“…IMRT is widely used in veterinary radiotherapy ( Kitagawa et al ., 2020 ), and it is important to maintain optimal MLC transmission in IMRT to provide the best treatment. Various methods for adjusting the transmission required for IMRT have been validated in human medicine, but none has been reported in veterinary medicine.…”

“…Another limitation of this study was that we could not compare the validation results of diode arrays and films. Some veterinary hospitals use a diode array for QA of the plan ( Kitagawa et al , 2020 ); however, it is expensive, and our hospital did not have one. Since it may be clinically easier to perform QA with diode arrays than with film and chamber measurements, information on differences in the QA results of film and diode arrays even in dogs and cats would be useful.…”