“…281,296,297 Additional investigations such as DUS or DSA are indicated if physical examination by experienced staff determines maturation failure 6 weeks after AVF creation or poor prognostic signs (faint or absent thrill, complete access collapse proximally, discontinuous bruit, high pitch continuous systolic audible bruit, pulsatile AVF, small diameter or poorly defined vein, excessive depth, large accessory/collateral veins). 132,288,298 Non-matured AVFs frequently have one or more potentially remediable problems, and up to 80% can be salvaged after surgical or endovascular correction, 299,300 although thereafter cumulative survival rates are decreased and require more secondary interventions to maintain patency. 301 The most common causes of non-maturation are venous, arterial or anastomotic stenosis, competing veins or large patent branches, and excessive depth from the skin.…”