Outcome of 200 pediatric living donor liver transplantations in India

Mohan, Neelam; Karkra, Sakshi; Rastogi, Amit; Dhaliwal, Maninder; Raghunathan, Veena; Goyal, Deepak; Goja, Sanjay; Bhangui, Prashant; Vohra, Vijay; Piplani, Tarun; Sharma, Vivek; Gautam, Dheeraj; Baijal, Sanjay Saran; Soin, Arvinder S.

doi:10.1007/s13312-017-1181-4

Cited by 27 publications

(44 citation statements)

References 24 publications

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“…When death and LT are taken as separate outcomes, King's College criteria and Liver Injury Unit score are not good predictors of outcome in children with ALF. [266][267][268] Presence of $3 King's College criteria for nonacetaminophen liver failure have been used as criteria to list for LT. 269 PELD score for children aged <12 years and MELD score for children aged >12 years are also used to assess disease severity. Serial rise in PELD/MELD scores or in prothrombin time 246 have been used as listing criteria for LT.…”

Section: Indications Of Lt In Childrenmentioning

confidence: 99%

Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure

Anand

Nandi²,

Acharya

et al. 2020

Journal of Clinical and Experimental Hepatology

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Acute liver failure (ALF) is not an uncommon complication of a common disease such as acute hepatitis. Viral hepatitis followed by antituberculosis drug-induced hepatotoxicity are the commonest causes of ALF in India. Clinically, such patients present with appearance of jaundice, encephalopathy, and coagulopathy. Hepatic encephalopathy (HE) and cerebral edema are central and most important clinical event in the course of ALF, followed by superadded infections, and determine the outcome in these patients. The pathogenesis of

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Section: Indications Of Lt In Childrenmentioning

confidence: 99%

Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure

Anand

Nandi²,

Acharya

et al. 2020

Journal of Clinical and Experimental Hepatology

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“…[ 16 ] With advances in surgical technique, pediatric anesthesia and critical care, and multidisciplinary team approach, excellent outcomes have been achieved even in very young and small infants. [ 17 ] In India, the 5- and 10-year survival rates in children after LRLT are 98% and 90%, respectively. [ 18 ]…”

Section: S Urgical I Ssues U mentioning

confidence: 99%

Biliary atresia, changing trends in management: Outlook of a pediatric liver transplant surgeon

Kumar

2018

J Indian Assoc Pediatr Surg

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“…AGS is a multisystem disorder with an autosomal dominant inheritance pattern caused by mutations either in JAG1 or NOTCH2 genes . The prevalence of AGS is 1 in 70 000 live births but published literature from India is restricted to isolated case reports/series and data on LT in AGS in children are limited . 20%‐30% of children with AGS will require LT over their lifetime .…”

Section: Introductionmentioning

confidence: 99%

Living donor liver transplantation in Alagille syndrome—Single center experience from south Asia

Valamparampil¹,

Reddy²,

Shanmugam³

et al. 2019

Pediatric Transplantation

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To analyze the clinical characteristics and the outcomes of living donor liver transplantation in children with Alagille syndrome (AGS). Clinical data of children with AGS who underwent liver transplantation between July 2009 and May 2019 in our unit were retrospectively analyzed. Primary end‐points were patient and graft survival. Ten children with AGS underwent living donor liver transplantation at a median age of 28 months (range, 12‐84 months). Jaundice was the most common initial symptom and was noted after a median duration of 20 days after birth (range, 7‐60 days). Two patients had undergone Kasai porto‐enterostomy for misdiagnosis of biliary atresia. The most common indication for transplantation was severe pruritus with poor quality of life. Explant livers in three children showed cirrhosis with early well‐differentiated hepatocellular carcinoma. We have 100% patient and graft survival at a mean follow‐up of 32 months (range 3‐72 months). The median z‐score for weight and height at liver transplantation was −2.66 (range: −6.44 to −0.9) and −3.6 (range: −7.96 to −0.93) while at follow‐up was −1.7 (range: −3.4 to −0.35) and −2.1 (range: −3.9 to −1.4), respectively. The estimated glomerular filtration rate was normal pretransplant and follow‐up. This is the first series of LDLT for Alagille syndrome in the Indian sub‐continent. We report excellent post‐transplant outcomes in contrast to outcomes reported from Western literature.

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Outcome of 200 pediatric living donor liver transplantations in India

Cited by 27 publications

References 24 publications

Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure

Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure

Biliary atresia, changing trends in management: Outlook of a pediatric liver transplant surgeon

Living donor liver transplantation in Alagille syndrome—Single center experience from south Asia

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