Outcome measures used in psoriatic arthritis registries and cohorts: A systematic literature review of 27 registries or 16,183 patients

Aouad, K.; Moysidou, G. S.; Rakotozafiarison, Antsa; Fautrel, Bruno; Gossec, Laure

doi:10.1016/j.semarthrit.2021.06.008

Cited by 13 publications

(8 citation statements)

References 42 publications

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“…Our work studied the main characteristics of patients with PsA, followed in real life, in a regional university reference center. Their inclusion over 4 consecutive months allowed us to find rather young patients (the mean age of onset of musculoskeletal and skin involvement was 42.2 and 32.6 years, respectively), in line with recent data [7] and above all a sex ratio of 1, similar with other publications [8] and thus to highlight some gender disparities, which is little described while some recent data suggest differences in response to treatment between men and women, as showed by Coates and al [9]. The prevalence of cardiovascular risk factors is not negligible in our PsA population.…”

Section: Discussionsupporting

confidence: 90%

Current characteristics of a population of psoriatic arthritis and gender disparities

et al. 2023

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Background and Aim: Psoriatic arthritis (PsA) is a polymorphic disease associated with numerous comorbidities. The objective of this study was to describe the main clinicobiological and imaging characteristics of a population of PsA and to extract any disparities between men and women. Methods: A total of 132 patients in the rheumatology department of Amiens University Hospital with a confirmed diagnosis of PsA according to the CASPAR criteria were included over a period of 4 months. All data were collected retrospectively in this observational and single-center study. Results: The sex ratio was 1 and the average age at inclusion was 54.9 years. Peripheral PsA was the predominant clinical form. Axial PsA represented 12.1% of cases. Enthesitis was noted in 52.3% of cases while dactylitis was identified in 29.5% of cases. Moreover, 12.1% had a joint symptomatology preceding the appearance of cutaneous signs. HLA-B*27 positivity was found in 33.3% of cases. Chronic hyperuricemia accounted for 10% of our population. Sacroiliitis was observed in 41% of cases. The disparities between men and women are multiple and consistent with the literature: Polyarticular form, enthesitis, obesity, more intensive prescription of s-DMARDs, and b-DMARDs are more associated with the female population. Oligoarticular form, psoriatic nail dystrophy, radiological axial involvement, and chronic hyperuricemia are more encountered in the male population. Conclusions: Our study found a very heterogeneous disease, with marked differences between men and women. Peripheral PsA remains predominant but the search for associated axial involvement, which is probably underestimated, seems essential. Relevance for Patients: This work studied the main characteristics of patients with PsA followed in real life, in a regional university reference center. We have highlighted a very heterogeneous disease as well as some gender disparities, not well described in the literature, which should be taken into account in order to optimize therapeutic management.

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Section: Discussionsupporting

confidence: 90%

Current characteristics of a population of psoriatic arthritis and gender disparities

et al. 2023

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“…To strengthen our analysis of the effect of LDA status on work and activity impairment, we used both the PsA-specific PASDAS and the DAS28-CRP. While this latter composite disease activity score was originally developed for use in rheumatoid arthritis (RA), and despite the fact that a 28 joint based score is not advised for PsA [ 17 ], the DAS28-CRP is still often used for PsA [ 18 , 19 ]. A higher score in DAS28-CRP defines a higher disease activity.…”

Section: Methodsmentioning

confidence: 99%

Determinants of work and social participation in patients with psoriatic arthritis in the Netherlands: an observational study

et al. 2022

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Background Psoriatic arthritis can cause pain, disability, and permanent joint damage. This can lead to impairments in work and social participation. Little is known about the extent of these impairments in routine practice. With this study, we aim to examine the extent of work and activity impairment in (subgroups of) Dutch patients with psoriatic arthritis (PsA), and to examine determinants associated with this impairment. Methods This is an observational study using data collected from the electronic health records of PsA patients treated at the Sint Maartenskliniek, the Netherlands. Data about work and activity impairment were collected via the Work Productivity and Activity Impairment questionnaire. To compare our PsA-cohort with the Dutch general population, we used age- and sex-matched data derived from the Central Bureau of Statistics. Regression analyses were performed to examine determinants of work and activity impairment. Results In total, 246 patients were included, of which 126 (51.2%) were female. Mean age (S.D.) was 55.7 (13.2) years. Compared with the Dutch general population, work for pay (WFP) was significantly lower in PsA (52.9% versus 62.6%, P < 0.001). In PsA, younger age and better physical function were associated with WFP status (P < 0.05). Higher disease activity, worse physical function, and worse mental health-related quality of life were associated with both more work and activity impairment (P < 0.05). Furthermore, reaching low disease activity status (LDA) according to Psoriatic ArthritiS Disease Activity Score (PASDAS; ≤ 3.2) was associated with less work and activity impairment than reaching LDA according to DAS28-CRP (≤ 2.9) (P < 0.05). Conclusions In PsA patients, worse physical function was associated with a lower likelihood of having WFP, and higher work and activity impairment. PASDAS LDA as a goal for treat to target, compared to DAS28-CRP, appears to favour the reduction of work and activity impairment.

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“…Each patient was evaluated by a rheumatologist as having PsA according to the Classification Criteria for Psoriatic Arthritis (CASPAR) criteria [ 11 ]. PsA clinical disease activity was measured according to Disease Activity in Psoriatic Arthritis (DAPSA) [ 12 ]. Patients with PsA were not receiving treatment for PsA.…”

Section: Methodsmentioning

confidence: 99%

Central Pain Sensitization in Patients with Chronic Plaque Psoriasis

Bellinato

Gisondi

Fassio

et al. 2023

Dermatol Ther (Heidelb)

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Background Central sensitization (CS) is a condition characterized by a disproportionate response to pain stimuli, and is associated with chronic pain conditions such as fibromyalgia, but also with inflammatory arthropathies such as rheumatoid arthritis and psoriatic arthritis (PsA). CS has never been investigated in patients with psoriasis. The aim of this study is to investigate CS in patients with chronic plaque psoriasis. Methods This research involved a cross-sectional observational study of adult patients with moderate-to-severe psoriasis consecutively attending the outpatient clinic of the University Hospital of Verona. Demography, measures of disease severity or activity [i.e., Psoriasis Area and Severity Index (PASI), Disease Activity in Psoriatic Arthritis (DAPSA)], diagnosis of PsA, hypertension, and diabetes were collected. Central Sensitization Inventory (CSI), Dermatology Life Quality Index (DLQI), General Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9) were administered. Results A total of 194 patients, including 115 (59%) men, with mean age of 54 ± 13 years, mean PASI of 12.7 ± 6.7, and mean DAPSA of 14.4 ± 3.8 were included. In total, 134 patients (79%) had only psoriasis while 60 (31%) had psoriasis and PsA; 19 (10%) patients had CSI score ≥ 40, which is the threshold for diagnosing CS. The proportion of CS ≥ 40 was higher in patients with PsA compared with psoriasis (17% versus 7%, p = 0.031). The mean CSI score in patients with PsA was higher compared with those with only psoriasis (27.5 ± 13.5 versus 20.7 ± 13.7, p = 0.002). An association between CSI and DLQI [ β = 1.25 (95% CI 0.85–1.66)], PASI [ β = 1.22 (95% CI 0.74–1.65)], GAD-7 [ β = 2.07 (95% CI 1.69–2.45)] and PHQ-9 [ β = 2.16 (95% CI 1.76–2.54)] was found independently from age, gender, diabetes, and PsA. Conclusions Central sensitization may be associated with psoriasis, particularly in those with high PASI, concomitant PsA, anxiety, depression, and severe quality of life impairment. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-023-00917-z.

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Outcome measures used in psoriatic arthritis registries and cohorts: A systematic literature review of 27 registries or 16,183 patients

Cited by 13 publications

References 42 publications

Current characteristics of a population of psoriatic arthritis and gender disparities

Current characteristics of a population of psoriatic arthritis and gender disparities

Determinants of work and social participation in patients with psoriatic arthritis in the Netherlands: an observational study

Central Pain Sensitization in Patients with Chronic Plaque Psoriasis

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