Outcome measures of interepisode bipolar patients in a Turkish sample

Özer, Sema; Uluşahin, Aylin; Batur, Senar; Kabakçı, Elif; Saka, Meram Can

doi:10.1007/s127-002-8211-z

Cited by 40 publications

(34 citation statements)

References 30 publications

(19 reference statements)

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“…Poor functional outcome in bipolar disorder has been associated with treatment non-compliance [74], comorbid substance abuse [75,76,77], anxiety disorders [78, 79], presence of mixed affective states [80, 81], psychosis [12, 82], number of past episodes [5, 16, 83, 84], rapid cycling [85, 86], history of suicidal behaviour and medical comorbidities [28, 85, 87], personality features [85, 88] and hospitalizations [17,89,90,91]. …”

Section: Resultsmentioning

confidence: 99%

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Functioning and Disability in Bipolar Disorder: An Extensive Review

Sanchez-Moreno

Martínez-Àran

Tabarés‐Seisdedos

et al. 2009

Psychother Psychosom

355

282

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Background: Bipolar disorder has generally been regarded as having a better functional outcome than schizophrenia. However, studies have suggested low functioning in bipolar patients even when they are in clinical remission. Our aim was to determine the degree of functioning and disability in bipolar patients. Secondly, we reviewed factors potentially associated with the low functioning of bipolar patients. Method: The authors conducted an extensive Medline and Pubmed search of the published literature from 1980 up to December 2007, using a variety of search terms to find relevant articles. Bibliographies of retrieved papers were further analysed for publications of interest. Articles that reported clinically significant findings on functioning and disability, and research reports were reviewed in detail. Results: From these articles, we determined that bipolar disorder is associated with significant impairment in work, family and social life, beyond the acute phases of the illness. The aspects that appear to increase the risk of low functioning and disability in bipolar patients are mainly subsyndromal symptoms and neurocognitive impairment, among others. Conclusions: Suitable pharmacological and psychological interventions may improve the level of functioning and reduce the disability in bipolar patients. Potential targets to be considered for intervention should be residual symptoms, comorbid conditions and neurocognitive deficits. Further research is required to better identify the factors that best predict functioning in bipolar patients.

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Section: Resultsmentioning

confidence: 99%

“…Ozer et al [90] found that all of these measures related to quality of life, disability and overall functioning evaluated the same areas of life, e.g. social, occupational and vocational life.…”

Section: Resultsmentioning

confidence: 99%

Functioning and Disability in Bipolar Disorder: An Extensive Review

Sanchez-Moreno

Martínez-Àran

Tabarés‐Seisdedos

et al. 2009

Psychother Psychosom

355

282

View full text Add to dashboard Cite

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“…A study by Ozer and colleagues [38] assessed 100 interepisode patients with BD in Turkey with the aim of examining the impact of 'history of illness' and 'present symptomatology' factors upon a variety of outcome measures including the Schedule for Affective Disorder and Schizophrenia (SADS) and Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) [39]. The Q-LES-Q is a 93-item self-report measure of the degree of enjoyment and satisfaction in various areas of daily living.…”

Section: I) Assessment Of Qol In Patients With Bd At Different Stagesmentioning

confidence: 99%

Quality of Life in Bipolar Disorder: A Review of the Literature

Michalak

Yatham

Lam

2007

FOC

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A sizable body of research has now examined the complex relationship between quality of life (QoL) and depressive disorder. Uptake of QoL research in relation to bipolar disorder (BD) has been comparatively slow, although increasing numbers of QoL studies are now being conducted in bipolar populations. We aimed to perform a review of studies addressing the assessment of generic and health-related QoL in patients with bipolar disorder.A literature search was conducted in a comprehensive selection of databases including MEDLINE up to November 2004. Key words included: bipolar disorder or manic-depression, mania, bipolar depression, bipolar spectrum and variants AND quality of life, health-related QoL, functional status, well-being and variants. Articles were included if they were published in English and reported on an assessment of generic or health-related QoL in patients with BD. Articles were not included if they had assessed fewer than 10 patients with BD, were only published in abstract form or only assessed single dimensions of functioning.The literature search initially yielded 790 articles or abstracts. Of these, 762 did not meet our inclusion criteria, leaving a final total of 28 articles. These were sub-divided into four categories (assessment of QoL in patients with BD at different stages of the disorder, comparisons of QoL in Patients with BD with that of other patient populations, QoL instrument evaluation in patients with BD and treatment studies using QoL instruments to assess outcome in Patients with BD) and described in detail.The review indicated that there is growing interest in QoL research in bipolar populations. Although the scientific quality of the research identified was variable, increasing numbers of studies of good design are being conducted. The majority of the studies we identified indicated that QoL is markedly impaired in patients with BD, even when they are considered to be clinically euthymic. We identified several important avenues for future research, including a need for more assessment of QoL in hypo/manic patients, more longitudinal research and the development of a diseasespecific measure of QoL for patients with BD.

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“…Persistent subsyndromal depressive symptoms have substantial effects on cognitive 14 and psychosocial functioning. 16,17 Medication side effects may also worsen cognitive functions 15 and have some effects on psychosocial functioning. 18 Previous psychotic symptoms seem to affect cognitive functions 19 and quality of life.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder: an empirical cross-sectional study

Aydemi̇r

Çubukçuoğlu

Erdin

et al. 2014

Rev. Bras. Psiquiatr.

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Objective: This study aimed to evaluate the relationship between oxidative stress markers and cognitive functions and domains of psychosocial functioning in bipolar disorder. Methods: Oxidative stress markers, cognitive functions, and domains of psychosocial functioning were evaluated in 51 patients with bipolar disorder who were in remission. Correlation analyses between these parameters were calculated with data controlled for duration of illness and number of episodes.Results: There was no statistically significant correlation between oxidative stress markers and cognitive functions. In terms of psychosocial functioning, significant correlations were found between malondialdehyde and sense of stigmatization (r = -0.502); household activities and superoxide dismutase (r = 0.501); participation in social activities and nitric oxide (r = 0.414); hobbies and leisure time activities and total glutathione (r = -0.567), superoxide dismutase (r = 0.667), and neurotrophin 4 (r = 0.450); and taking initiative and self-sufficiency and superoxide dismutase (r = 0.597). There was no correlation between other domains of psychosocial functioning and oxidative stress markers. Conclusion: These results imply that oxidative stress markers do not appear to correlate clearly with cognitive impairment and reduced psychosocial functioning. However, there were some associations between selected oxidative markers and activity-oriented functional markers. This may represent a true negative association, or may be an artifact of oxidative stress being a state rather than a trait marker.

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Outcome measures of interepisode bipolar patients in a Turkish sample

Abstract: Our findings suggest that outcome measures were correlated with subsyndromal disorder, the number of previous depressive episodes and the duration of hospitalisation.

Cited by 40 publications

References 30 publications

Functioning and Disability in Bipolar Disorder: An Extensive Review

Functioning and Disability in Bipolar Disorder: An Extensive Review

Quality of Life in Bipolar Disorder: A Review of the Literature

Oxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder: an empirical cross-sectional study

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