Outcome Measures in Randomized-controlled Trials of Neuropathic Pain Conditions

Abstract

(2015) Outcome measures in randomized controlled trials of neuropathic pain conditions: a systematic review of systematic reviews and recommendations for practice. Clinical Journal of Pain, 31 (2). pp. 169-176. ISSN 1536-5409 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/40598/4/CJP-D-13-00061%20revised %202%20submission.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the University of Nottingham End User licence and may be reused according to the conditions of the licence. For more details see: http://eprints.nottingham.ac.uk/end_user_agreement.pdf A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Objectives: Neuropathic pain (NeP) is a prevalent, disabling, multi-dimensional condition with significant morbidity; however there appears to be a variable approach in the use of outcome measures in NeP trials. A search of systematic reviews of interventional randomized controlled trials for NeP was undertaken to investigate the range and types of outcome measures employed to determine treatment effects. Methods: Keywords and MESH searches were conducted in five electronic databases from inception to 31st January 2012. Full text English language reviews based on various acute and chronic NeP conditions were included. Two independent reviewers screened papers for inclusion, extracted data, and assessed the quality of reviews. Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used to critically appraise the reviews.

Prediction of response to tapentadol in chronic low back pain

“…It is very likely, however, that outcome parameters like improvement of quality‐of‐life or increase in functional ability might be more important for the patients' overall well‐being. Thus, the identification of predictors that impact on these alternative outcome parameters would improve pain management in clinical practice (Mehta et al., 2015). …”