Outcome Measurement in Children With a History of Disorders of Consciousness After Severe Brain Injury: Telephone Administration of the Vineland Adaptive Behavior Scales, Third Edition, and Glasgow Outcome Scale-Extended Pediatric Revision

Ludwig, Natasha N; Suskauer, Stacy J.; Rodgin, Sandra; Chen, Julia; Borda, Allison; Jones, Kenneth R.; Lahey, Sarah; Slomine, Beth S.

doi:10.1097/pcc.0000000000003121

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…In another study, feasibility and utility of measures of long-term outcomes collected via telephone interview was examined in a convenience sample of 41 caregivers of children from two different hospitals who were admitted to inpatient rehabilitation in a state of DoC following either traumatic or acquired brain injury, using the Vineland-3, a detailed measure of neurobehavioral functioning, and the Glasgow Outcome Scale -Extended for Pediatrics (GOS-E Peds), a much shorter measure of global neurological functioning [85,86]. All those who consented completed the interview.…”

Section: Long-term Outcomes Assessmentmentioning

confidence: 99%

Proceedings of the First Pediatric Coma and Disorders of Consciousness Symposium by the Curing Coma Campaign, Pediatric Neurocritical Care Research Group, and NINDS: Gearing for Success in Coma Advancements for Children and Neonates

et al. 2023

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This proceedings article presents the scope of pediatric coma and disorders of consciousness based on presentations and discussions at the First Pediatric Disorders of Consciousness Care and Research symposium held on September 14th, 2021. Herein we review the current state of pediatric coma care and research opportunities as well as shared experiences from seasoned researchers and clinicians. Salient current challenges and opportunities in pediatric and neonatal coma care and research were identified through the contributions of the presenters, who were Jose I.

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Section: Long-term Outcomes Assessmentmentioning

confidence: 99%

Proceedings of the First Pediatric Coma and Disorders of Consciousness Symposium by the Curing Coma Campaign, Pediatric Neurocritical Care Research Group, and NINDS: Gearing for Success in Coma Advancements for Children and Neonates

et al. 2023

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“…Research employing a single measure of global functioning following pABI is scarce (116) even though there is a developmentally appropriate version of GOS-E, the pediatric version of GOS-E (GOS-E Peds) (117). Despite strong associations to functional independence (measured by Vineland Adaptive Behavior Scale) lending support to its concurrent validity for assessing longterm outcomes (118,119), GOS-E Peds is rarely used. Prospective pABI studies have demonstrated significant improvement in disability during the first year post-injury, followed by minor subsequent improvement (120,121).…”

Section: Introductionmentioning

confidence: 99%

Intelligence and executive function are associated with age at insult, time post-insult, and disability following chronic pediatric acquired brain injury

Brandt,

Rø,

Finnanger

et al. 2024

Front. Neurol.

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BackgroundPediatric acquired brain injury (pABI) profoundly affects cognitive functions, encompassing IQ and executive functions (EFs). Particularly, young age at insult may lead to persistent and debilitating deficits, affecting daily-life functioning negatively. This study delves into the intricate interplay of age at insult, time post-insult, and their associations with IQ and EFs during chronic (>1 year) pABI. Additionally, we investigate cognitive performance across different levels of global function, recognizing the multifaceted nature of developmental factors influencing outcomes.MethodsDrawing upon insult data and baseline information analyzing secondary outcomes from a multicenter RCT, including comprehensive medical and neuropsychological assessments of participants aged 10 to 17 years with pABI and parent-reported executive dysfunctions. The study examined associations between age at insult (early, EI; ≤7y vs. late, LI; > 7y) and time post-insult with IQ and EFs (updating, shifting, inhibition, and executive attention). Additionally, utilizing the Pediatric Glasgow Outcome Scale-Extended, we explored cognitive performance across levels of global functioning.ResultsSeventy-six participants, median 8 years at insult and 5 years post-insult, predominantly exhibiting moderate disability (n = 38), were included. Notably, participants with LI demonstrated superior IQ, executive attention, and shifting compared to EI, [adjusted mean differences with 95% Confidence Intervals (CIs); 7.9 (1.4, 14.4), 2.48 (0.71, 4.24) and 1.73 (0.03, 3.43), respectively]. Conversely, extended post-insult duration was associated with diminished performances, evident in mean differences with 95% CIs for IQ, updating, shifting, and executive attention compared to 1–2 years post-insult [−11.1 (−20.4, −1.7), −8.4 (−16.7, −0.1), −2.6 (−4.4, −0.7), −2.9 (−4.5, −1.2), −3.8 (−6.4, −1.3), −2.6 (−5.0, −0.3), and −3.2 (−5.7, −0.8)]. Global function exhibited a robust relationship with IQ and EFs.ConclusionEarly insults and prolonged post-insult durations impose lasting tribulations in chronic pABI. While confirmation through larger studies is needed, these findings carry clinical implications, underscoring the importance of vigilance regarding early insults. Moreover, they dispel the notion that children fully recover from pABI; instead, they advocate equitable rehabilitation offerings for pABI, tailored to address cognitive functions, recognizing their pivotal role in achieving independence and participation in society. Incorporating disability screening in long-term follow-up assessments may prove beneficial.

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Plasma profiles of inflammatory cytokines in children with moderate to severe traumatic brain injury: a prospective cohort study

Huang,

Fu,

et al. 2024

Eur J Pediatr

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Outcome Measurement in Children With a History of Disorders of Consciousness After Severe Brain Injury: Telephone Administration of the Vineland Adaptive Behavior Scales, Third Edition, and Glasgow Outcome Scale-Extended Pediatric Revision

Abstract: Examine initial feasibility and utility of a battery of measures administered via telephone interview with a caregiver for describing long-term outcomes in individuals with a history of disorders of consciousness (DoC) after pediatric acquired brain injury (ABI).

Cited by 4 publications

References 20 publications

Proceedings of the First Pediatric Coma and Disorders of Consciousness Symposium by the Curing Coma Campaign, Pediatric Neurocritical Care Research Group, and NINDS: Gearing for Success in Coma Advancements for Children and Neonates

Proceedings of the First Pediatric Coma and Disorders of Consciousness Symposium by the Curing Coma Campaign, Pediatric Neurocritical Care Research Group, and NINDS: Gearing for Success in Coma Advancements for Children and Neonates

Intelligence and executive function are associated with age at insult, time post-insult, and disability following chronic pediatric acquired brain injury

Plasma profiles of inflammatory cytokines in children with moderate to severe traumatic brain injury: a prospective cohort study

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