Outcome in Schizoaffective, Psychotic, and Nonpsychotic Depression

Coryell, William

doi:10.1001/archpsyc.1984.01790190061008

Cited by 111 publications

(32 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prusoff et al [1984] found that first-degree relatives of delusional depressives were 1.5 times more likely to have major depression than were the relatives of nondelusional depressed patients, and 3.5 times more likely to have major depression than were relatives of normal controls. In contrast, Coryell et al [1984] did not detect a difference in family risk for depression between patients with psychotic depression versus patients with nonpsychotic depression; however, patients with psychotic depression were more likely to have a family history of schizophrenia. Coryell et al [1982] contrasted the family histories of patients with moodcongruent psychotic depression and mood-incongruent psychotic depression.…”

Section: Genetic Implications Of Psychosis In Bipolar Disordercontrasting

confidence: 67%

Heterogeneity and the genetics of bipolar disorder

Faraone

Tsuang

2003

American J of Med Genetics Pt C

View full text Add to dashboard Cite

Section: Genetic Implications Of Psychosis In Bipolar Disordercontrasting

confidence: 67%

Heterogeneity and the genetics of bipolar disorder

Faraone

Tsuang

2003

American J of Med Genetics Pt C

View full text Add to dashboard Cite

“…Moreover, with regard to clinical symptomatology, up to 50% of otherwise typical bipolar patients have clear-cut psychotic symptoms (hallucinations, delusions, formal thought disorder) during episodes, 891011 , as well as sharing some of the cognitive abnormalities that were thought originally only to characterize schizophrenia patients 12 . One consequence of this is that many cases of psychosis are hard to classify, and are thereby omitted from both clinical trials and genetic analyses, inevitably skewing study outcomes.…”

Section: Problems With Kraepelin’s Distinctionmentioning

confidence: 99%

Does Biology Transcend the Symptom-based Boundaries of Psychosis?

Pearlson

Clementz

Sweeney

et al. 2016

Psychiatric Clinics of North America

View full text Add to dashboard Cite

Synopsis Psychotic disorders, as defined by clinical features alone, overlap considerably in terms of symptoms, familial patterns, risk genes, outcome and treatment response. As a result, numerous neurobiological measurements also fail to distinguish patients with the most prevalent classic psychotic syndromes (schizophrenia, schizo-affective and bipolar with psychosis). Statistical methods applied to such biological measurements in large numbers of psychosis patients yield novel categories, that cut across traditional diagnostic boundaries, called “Biotypes”, i.e. biologically-defined presumptive disease entities. Such new classification approaches within psychosis hopefully represent an opportunity to transcend clinical phenomenologically-defined syndromes in psychiatry with neurobiologically-defined diseases that can advance drug discovery and support precision medicine approaches in psychiatry.

show abstract

“…It has also been shown that patients with a history of psychosis, regardless of a diagnosis, are impaired on a variety of cognitive measures, such as executive functioning, verbal learning and memory, verbal fluency, control inference (Glahn et al, 2007;Martinez-Aran et al, 2008;Simonsen et al, 2011;Udal et al, 2012) and additionally, psychotic features in mood disorders have validity in terms of prognosis, treatment response and family history for psychiatric illness (Mazzarini et al, 2010;Souery et al, 2011;Schultze-Lutter et al, 2012). It has also been shown that psychotic symptoms in mood disorders are associated with higher number of hospitalizations (Jager et al, 2005), poorer response to medications (Coryell et al, 1984), increased recurrence (Tohen et al, 2003), greater symptom severity worse short-and long-term outcome (Coryell et al, 2001), longer duration of recovery (Geller et al, 2002) and overall greater functional impairment (Haro et al, 2006). Moreover, executive dysfunction in BPD patients was reported to be related to a history of psychosis in their families (Tabares-Seisdedos et al, 2003).…”

Section: Comparison Of Cognitive Performance Between Bpd(+) and Bpd(−mentioning

confidence: 99%

Impairments of Working Memory in Schizophrenia and Bipolar Disorder: the Effect of History of Psychotic Symptoms and Different Aspects of Cognitive Task Demands

Hewedi

Frydecka

Moustafa

2015

European Psychiatry

View full text Add to dashboard Cite

Comparisons of cognitive impairments between schizophrenia (SZ) and bipolar disorder (BPD) have produced mixed results. We applied different working memory (WM) measures (Digit Span Forward and Backward, Short-delay and Long-delay CPT-AX, N-back) to patients with SZ (n = 23), psychotic BPD (n = 19) and non-psychotic BPD (n = 24), as well as to healthy controls (HC) (n = 18) in order to compare the level of WM impairments across the groups. With respect to the less demanding WM measures (Digit Span Forward and Backward, Short-delay CPT-AX), there were no between group differences in cognitive performance; however, with respect to the more demanding WM measures (Long-delay CPT-AX, N-back), we observed that the groups with psychosis (SZ, psychotic BPD) did not differ from one another, but performed poorer than the group without a history of psychosis (non-psychotic BPD). A history of psychotic symptoms may influence cognitive performance with respect to WM delay and load effects as measured by Long-delay CPT-AX and N-back tests, respectively. We observed a positive correlation of WM performance with antipsychotic treatment and a negative correlation with depressive symptoms in BPD and with negative symptoms in SZ subgroup. Our study suggests that WM dysfunctions are more closely related to a history of psychosis than to the diagnostic categories of SZ and BPD described by psychiatric classification systems.

show abstract

Outcome in Schizoaffective, Psychotic, and Nonpsychotic Depression

Cited by 111 publications

References 39 publications

Heterogeneity and the genetics of bipolar disorder

Heterogeneity and the genetics of bipolar disorder

Does Biology Transcend the Symptom-based Boundaries of Psychosis?

Impairments of Working Memory in Schizophrenia and Bipolar Disorder: the Effect of History of Psychotic Symptoms and Different Aspects of Cognitive Task Demands

Contact Info

Product

Resources

About