Outcome in Neuroblastoma

Özgüven, Ali Aykan; Anak, Sema; Ünüvar, Ayşegül; Akçay, Arzu; Karakaş, Zeynep; Öztürk, Gülyüz; Devecioğlu, Ömer; Ağaoğlu, Leyla

doi:10.1007/s12098-014-1578-1

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…From our cohort of children with NWRTs, only a 2-year-old girl was diagnosed with primary intrarenal neuroblastoma. She was treated according to the national neuroblastoma protocol entitled "Turkish Pediatric Oncology Group Neuroblastoma Protocol 2009" as described by Ozguven et al [29]. Our case was not MYCN-amplified and showed remission after complete nephrectomy without further chemotherapy.…”

Section: Discussionmentioning

confidence: 89%

Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey

et al. 2019

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Background/aim: Non-Wilms renal tumors (NWRTs) are rarely encountered in children. The aim of this study is to determine the treatment strategies, prognosis, outcomes, and survival of children with NWRTs at Erciyes University in Kayseri, Turkey. Materials and methods: Medical records of all patients (n = 20) treated for NWRTs over a 23-year period (1995-2018) were reviewed retrospectively. Results: There was male predominance (female/male: 7/13); the median age at diagnosis was 3.2 years old (0.1-13.5 years old). The major histological groups included mesoblastic nephroma (MBN), (n: 5, 25%), malignant rhabdoid tumor (MRT), (n: 5, 25%), renal cell carcinoma, (n: 3, 15%), inflammatory myofibroblastic tumor (n: 2, 10%), multilocular cystic renal tumors (n: 2, 10%), metanephric adenoma (n: 1, 5%), renal neuroblastoma (n: 1, 5%), and bilateral renal Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) (n: 1, 5%). All of the patients with NWRTs had radical nephrectomy except the child with bilateral renal ES/PNET. Six children died because of progressive disease; the mortality rate was 30% (n: 6). Conclusion: We have made the first report of bilateral renal involvement of ES/PNET in the English medical literature. Physicians dealing with pediatric renal masses should be alert to the high mortality rate in children with MRT, MBN, and ES/PNET and they should design substantial management plans for NWRTs.

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Section: Discussionmentioning

confidence: 89%

Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey

et al. 2019

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“…The overall survival (OS) was 74.0 ± 7.3% at 36 months (Figure 2). In a study by Ali Aykan Ozguven, the EFS at 60 and 108 months was 84.7 ± 7.7% and 72.6 ± 7.7%, respectively, and the OS was 91.7 ± 8% at 108 months [11]. In another study, the 5-year OS and EFS were 62% and 52%, respectively, and the 10-year OS and EFS were 53% and 47%, respectively [13].…”

Section: Clinical and Laboratory Featuresmentioning

confidence: 97%

Application of the International Neuroblastoma Risk Group Staging System 2009 (Inrgss 2009) in Diagnosis and Prognosis of Childhood Neuroblastoma

Nguyen,

Chau,

Nguyen

et al. 2024

VMJ

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Background: Neuroblastoma is the most common extracranial solid tumor of childhood. INRGSS 2009 divides patients into stages L1, L2, M, Ms, from which, in combination with histopathology, molecular biology, each patient will be divided into risk groups from which to guide prognosis and suitable treatment. Objectives: Describe the clinical and laboratory features of neuroblastoma in children; distribution of pediatric neuroblastoma stages according to the INRGSS 2009 classification and its value in predicting survival outcomes. Methods: This was a cross-sectional study combined with retrospective and prospective. Patients were diagnosed with neuroblastoma and classified according to INRGSS 2009 at the Pediatric Center, Hue Central Hospital. Results: The age at the time of diagnosis ranged from 1 day old to 9 years old, with a mean of 35.4 ± 25.5 months. Regarding primary tumor, 73.5% of cases were found in the abdomen, the mediastinum region (22.4%), an undetermined region (4.1%). Systemic symptoms, local symptoms and symptoms caused by metastasis were frequently reported. At the time of diagnosis, 73.5% of the patients had distant metastases (stage M or MS). The EFS of the whole group at 12 and 24 months old were 86.3 % and 64.7% respectively. The OS was 77.9% at 24 months old. Most of these patients had a progressive disease: 6.1% were in stage L1; 20.4% were in stage L2; 69.4% were in stage M; and 4.1% were in stage MS. Estimated mean of event-free survival for L1 was 38.7 ± 3.5 months, L2 was 40.5 ± 4.2 months and M was 28.0 ± 2.5 months (p < 0.05). Conclusions: Most neuroblastoma tumors are abdominal and have distant metastases. LDH and ferritin elevations are prevalent. Neuroblastoma outcomes can be predicted using the INRGSS 2009 classification.

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Outcome in Neuroblastoma

Cited by 2 publications

References 22 publications

Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey

Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey

Application of the International Neuroblastoma Risk Group Staging System 2009 (Inrgss 2009) in Diagnosis and Prognosis of Childhood Neuroblastoma

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