Outcome Comparisons Between Patients on Peritoneal Dialysis With and Without Polycystic Kidney Disease

Yang, Ju‐Yeh; Chen, Likwang; Chao, Chia‐Ter; Peng, Yu‐Sen; Chiang, Chih‐Kang; Kao, Tze-Wah; Chien, Kuo–Liong; Wu, Hon-Yen; Huang, Jenq‐Wen; Hung, Kuan‐Yu

doi:10.1097/md.0000000000002166

Cited by 13 publications

(21 citation statements)

References 20 publications

(24 reference statements)

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“…For the 9 studies [9, 16, 18-20, 22-24, 26] which examined the association of PD-related complications in PKD and non-PKD patients on PD, 7 studies [9,16,19,20,23,24,26] reported peritonitis, 6 studies [9,16,18,22,23,26] reported hernias and 5 studies [9,16,23,24,26] were leak. We found that there was no significantly statistical difference on PD-related complications in PKD and non- Fig.…”

Section: Literature Searchmentioning

confidence: 99%

“…The main features of the studies on the adverse outcomes for all articles in Table 1. 7 studies [16-19, 21, 24, 39] were conducted in Europe, with the exception of seven [9,20,22,23,25,26,40] conducted in Asia. Patients' age in PKD ranged from 35.4 to 63.6 years old, however, patients' age in non-PKD was higher than PKD, ranged from 46 to 61 years old.…”

Section: Literature Searchmentioning

confidence: 99%

“…Technique failure was defined as a permanent cessation of PD due to PDrelated complications. 5 studies [16,20,21,24,26] examined the association of technique failure in PKD and non-PKD patients on PD. We found that there was no significantly statistical difference on technique failure in PKD and non-PKD patients on PD (RR: 0.97, 95%CI: 0.78-1.20) without heterogeneity (Fig.…”

Section: Literature Searchmentioning

confidence: 99%

“…In recent years, scale observational studies [16][17][18][19][20] suggested that PKD was not a contraindication for PD. Moreover, it has even been suggested that PD may be associated with a better prognosis in PKD than that of non-PKD patients [9,16,17,19,[21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Is Peritoneal Dialysis a Suitable Renal Replacement Therapy Option for Polycystic Kidney Disease Patients?

Zhang¹,

Dou²,

Wang³

et al. 2018

Kidney Blood Press Res

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Background/Aims: Mounting clinical experience and evidence from scale observational studies have suggested that polycystic kidney disease (PKD) was not a contraindication for peritoneal dialysis (PD). Recent studies have reported that PD may be associated with a better prognosis in PKD than that of non-PKD patients. To solve the problem, we performed a systematic review and comprehensive meta-analysis to compare the outcomes between PKD and non-PKD patients on PD and the all-cause mortality between patients with PKD on PD and hemodialysis (HD). Methods: We conducted a systematic literature using electronic databases (PubMed, Ovid, Embase and Web of Science) to identify the studies reporting the endpoint events of PKD/non-PKD patients with PD and the all-cause mortality between patients with PKD on PD and HD, such as dialysis adequacy, technique failure, PD-related complications, the mode of RRT change, and all-cause mortality. We searched the literature published February 2018 or earlier. We used both fix-effects and random-effects models to calculate the overall effect estimate. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results: 12 studies with a total of 17,040 patients reported the endpoint events of PKD/non-PKD patients with PD. No significant difference was observed on dialysis adequacy (Kt/V, SMD: -0.02, 95%CI: -0.12–0.08; D: Pcr (4h), SMD: -0.10, 95% CI: -0.26–0.06), technique failure (RR: 0.97, 95%CI: 0.78-1.20), RRT change (RR: 0.96, 95%CI: 0.77-1.19), total PD-associated complications (RR: 1.0, 95%CI: 0.91-1.09) and all-cause mortality (RR: 0.40, 95%CI: 0.33–0.47) in PKD patients, compared with non-PKD subjects undergoing PD. However, the proportion of renal transplantation in PKD patients was higher than that of non-PKD patients (RR: 2.04, 95%CI: 1.88–2.20) with significant heterogeneity (I2 =82.7%, P=0.000). 4 studies with a total of 5,762 patients reported that the all-cause mortality did not differ between the PKD patients on PD and HD (RR: 0.87, 95%CI: 0.72-1.06). Conclusion: Our meta-analysis found that the outcomes of given population of PKD patients on PD were at least not inferior as compared to those with other primary kidney diseases, and suggested that PKD might be not absolutely a contraindication for PD. Given the limitations of the proposed, it needs further large-scale studies to assess whether PD is a suitable RRT option for end-stage renal disease (ESRD) patients with PKD.

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Section: Literature Searchmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is Peritoneal Dialysis a Suitable Renal Replacement Therapy Option for Polycystic Kidney Disease Patients?

Zhang¹,

Dou²,

Wang³

et al. 2018

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…However, whether PD is a feasible option for patients with ADPKD remains controversial due to inconsistent results. [7][8][9][10][11][12][13][14][15][16][17][18][19] Some did report higher rates of complications, while others have reported that PD in this patient population is well tolerated, with no difference in technique difficulty. Furthermore, some observational data suggested that the prognosis of ADPKD patients on PD may appear to be better than, or at least equivalent to, ADPKD patients on HD 5,20 as well as those with other aetiologies of ESRD on PD.…”

mentioning

confidence: 99%