Outcome and risk factors of vitreoretinal surgery in pediatric patients with familial exudative vitreoretinopathy

El‐Khoury, Sylvain; Clément, A; Chehaibou, Ismaël; Abdelmassih, Youssef; Edelson, C.; Metge, F.; Dureau, P.; Caputo, G.

doi:10.1007/s00417-020-04712-w

Cited by 7 publications

(8 citation statements)

References 13 publications

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“…We presumed that both adult and pediatric idiopathic macular ERMs may be caused by a transient or slight accumulation of cells or cytokines in the vitreoretinal interface which induced local and thin membrane formation, while pediatric secondary macular ERMs may be complicated in much sever vitreoretinal disease such as: ROP, FEVR, OT, etc. [14][15][16] those secondary etiologies of ERMs may cause greater activation of myo broblasts which are associated with premacular brosis (PMF) other than CMF.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and surgical outcomes of pediatric idiopathic and secondary macular epiretinal membrane

Liu

Wang

et al. 2023

Preprint

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Background: To describe and compare the different clinical characteristics and surgical outcomes of patients with pediatric idiopathic and secondary macular epiretinal membranes (ERMs). Methods: A cohort of pediatric patients (≤14years) underwent surgical removal of macular ERMs were selected from January 2019 to September 2021. Those patients were grouped into idiopathic macular ERMs group and secondary macular ERMs group, medical data including ocular manifestations were assessed and compared preoperatively and postoperatively. Results :A total of 41 patients (50 eyes) were included, mean age at surgery was 6.5 years (3～14 years), mean follow-up duration was 19.5months (12～31 months). Fourteen of the 41 patients (34.1%) had idiopathic macular ERMs. Compared with secondary macular ERMs, pediatric idiopathic ERMs had an older age at surgery(p=0.032) and were mostly found fortuitously by school visual acuity (VA) screening(p=0.028) with more cases with appearance of cellophane macular reflex (p=0.047); on OCT images, idiopathic macular ERMs were more likely to have taco folds (p=0.031)and less ellipsoid zone (EZ) disruptions (p=0.026) ; idiopathic macular ERMs were more likely to have better preoperative best corrected visual acuity (BCVA)(p<0.001); surgical removal of pediatric macular ERMs results in VA improvement with less postoperative complications in pediatric idiopathic ERMs. Conclusion: Pediatric idiopathic macular ERMs have many different clinical characteristics compared with that of pediatric secondary macular ERMs; surgical removal of pediatric macular ERMs results in VA improvement with less postoperative complications in pediatric idiopathic ERMs. Trial registration: Retrospective case series study, not applicable. NCT2378898

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and surgical outcomes of pediatric idiopathic and secondary macular epiretinal membrane

Liu

Wang

et al. 2023

Preprint

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“…11,17 Management Management and surgical approach have been previously described by our group. 10 All surgeries were performed under general anesthesia by two senior pediatric vitreoretinal surgeons (G.C., F.M.). In brief, laser photocoagulation/cryotherapy was performed on nonvascularized zones.…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…6,9 Clinical features include avascular peripheral retina, neovascularization, radial retinal folds (most often temporal), dragging of retinal vessels, ectopia maculae, epiretinal membranes, and tractional or rhegmatogenous RD. 6,10 Pendergast & Trese 11 classified FEVR into five stages based on the From the…”

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confidence: 99%

Early-onset of Familial Exudative Vitreoretinopathy: clinical characteristics, management and outcomes

Nicolas,

Thibaut,

Florence

et al. 2023

Retina

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Purpose: To describe the clinical characteristics, management and outcomes of toddlers (under the age of 3) diagnosed with Familial exudative vitreoretinopathy (FEVR). Methods: In this retrospective study we included patients diagnosed with FEVR before the age of 3. Presenting characteristics, genetic testing, management and outcomes were collected. Results: A total of 54 patients (108 eyes) with a mean age at diagnosis of 10.9±2.6 months were included. Poor visual behavior (33%) and strabismus (26%) were the most common presenting symptoms while screening only represented 11%. About half of included patients had a severe disease (stage 4 and 5). Genetic testing was positive in 40.7% of patients with 24% having a family history of FEVR. LRP5 was the most prevalent mutation (54.5%). Surgery was performed in 44.4% of eyes and was successful in 69.8% of cases. Failure exclusively occurred in eyes with severe stages. Among eyes evaluated for visual acuity (72 eyes), a majority (76.4%) had a vision of hand motion or better. Conclusion: FEVR tended to be worse with earlier age at diagnosis, subsequently affecting the prognosis. Surgical intervention was common and primarily included lens sparing vitrectomy and combined lensectomy and vitrectomy. Surgical success hinged on the stage of the disease.

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“…[19][20][21][22][23][24] However, anatomic and functional failures increase with higher stages of disease, where the risk for complications may also increase. 16,18,25,26 There is always a risk for complications with any surgery. Some issues in vitreoretinal surgery are expected, such as gradual cataract formation and transient ptosis.…”

Section: Introductionmentioning

confidence: 99%

“…The anatomic success rates of familial exudative vitreoretinopathy–related tractional retinal detachment (TRD) and rhegmatogenous retinal detachment also range from 63% to 96% 19–24. However, anatomic and functional failures increase with higher stages of disease, where the risk for complications may also increase 16,18,25,26…”

Section: Introductionmentioning

confidence: 99%

Surgical Complications in Retinopathy of Prematurity: Literature Review and Management Strategies

Wakabayashi

Yonekawa

2022

International Ophthalmology Clinics

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Outcome and risk factors of vitreoretinal surgery in pediatric patients with familial exudative vitreoretinopathy

Cited by 7 publications

References 13 publications

Clinical characteristics and surgical outcomes of pediatric idiopathic and secondary macular epiretinal membrane

Clinical characteristics and surgical outcomes of pediatric idiopathic and secondary macular epiretinal membrane

Early-onset of Familial Exudative Vitreoretinopathy: clinical characteristics, management and outcomes

Surgical Complications in Retinopathy of Prematurity: Literature Review and Management Strategies

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