2006
DOI: 10.1080/02841860600812701
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Outcome and late complications of radiotherapy in patients with unicentric Castleman disease

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Cited by 41 publications
(44 citation statements)
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References 23 publications
(28 reference statements)
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“…Characteristics of unicenter type Castleman's disease are as follows[1]: (1) males and females have the same incidence, with a median age of 37 years; (2) hyaline vascular type is the major pathologic type, accounting for 92%; (3) most lesions are in the mediastinum, neck, axillary, and retroperitoneal lymph nodes, and other rare locations include the intra-orbital region, hepatic portal, subcutaneous region, parotid glands, kidney, and pelvic cavity[2]–[7]; (4) the disease progresses very slowly, intact surgical excision could cure the disease and partial excision could significantly relieve symptoms. However, postoperative adjuvant radiotherapy is recommended due to the possibility of relapse after partial excision[8],[9]. Characteristics of multicenter type Castleman's disease are as follows: (1) males and females have the same incidence, with a median age of 53 years; (2) plasma cell and mixed variant types are the major pathologic types, accounting for 89%; (3) it is mainly treated by chemotherapy with adjuvant local radiotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…Characteristics of unicenter type Castleman's disease are as follows[1]: (1) males and females have the same incidence, with a median age of 37 years; (2) hyaline vascular type is the major pathologic type, accounting for 92%; (3) most lesions are in the mediastinum, neck, axillary, and retroperitoneal lymph nodes, and other rare locations include the intra-orbital region, hepatic portal, subcutaneous region, parotid glands, kidney, and pelvic cavity[2]–[7]; (4) the disease progresses very slowly, intact surgical excision could cure the disease and partial excision could significantly relieve symptoms. However, postoperative adjuvant radiotherapy is recommended due to the possibility of relapse after partial excision[8],[9]. Characteristics of multicenter type Castleman's disease are as follows: (1) males and females have the same incidence, with a median age of 53 years; (2) plasma cell and mixed variant types are the major pathologic types, accounting for 89%; (3) it is mainly treated by chemotherapy with adjuvant local radiotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…Radiotherapy can also achieve clinical response and cure in patients unsuitable for surgery or in patients who have undergone incomplete surgical excision. However, there have been reported possible complications and high recurrence rates [19][20][21][22][23][24].…”
Section: Resultsmentioning
confidence: 99%
“…Authors concluded that in patients with unresectable UCD lesions, radiotherapy will shrink the tumor and eventually lead to regression of the symptoms. Neuhof et al [23] reported the outcome in a small series of five patients with UCD that were managed either with surgery (partial excision) followed by post-operative RT or with RT alone. Patients who had the dual therapy showed no progression of the disease during the follow-up.…”
Section: Resultsmentioning
confidence: 99%
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“…preoperative embolization to limit intra-operative bleeding and adjuvant radiation therapy in case of incomplete resection (8,9). Radiotherapy has also been offered in a curative intent (10), but the experience remains limited and its long-term efficacy warrants confirmation.…”
Section: CDmentioning
confidence: 99%