Outcome after methadone treatment: influence of prior treatment factors and current treatment status

Strain, Eric C.; Stitzer, Maxine L.; Liebson, Ira A.; Bigelow, George E.

doi:10.1016/0376-8716(94)90078-7

Cited by 18 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absence of any effect of buprenorphine on cardiovascular activity produced by cocaine administration supports previous findings, suggesting that the probability of an adverse cardiovascular interaction between buprenorphine and cocaine is low (Foltin & Fischman, 1994; Mendelson et al, 1992; Teoh et al, 1993). Strain et al (1994) reported that maintenance on 8 mg buprenorphine had no effect on the response to 40 mg IV cocaine in 4 participants. Nonsignificant trends, however, were in the direction of enhanced cocaine effects.…”

Section: Discussionmentioning

confidence: 98%

“…The present results confirm previous laboratory studies showing that buprenorphine attenuated the effects of opioids (Bickel et al, 1988; Mello & Mendelson, 1980; Mello, Mendelson, & Kuehnle, 1982; but see Teoh et al, 1993, for an exception). Clinical data also indicate that buprenorphine maintenance decreases illicit opioid use (Kosten, Schottenfeld, Ziedonis, & Falcioni, 1993; Reisinger, 1985; Schottenfeld, Pakes, Ziedonis, & Kosten, 1993; Strain et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the abil ity to alter cocaine self-administration is not common to all opioid agonist–antagonists, as neither nalbuphine nor butorphanol selectively decrease cocaine self-administration compared with food in take of rhesus monkeys (Mello, Kamien, Lukas, Drieze, & Mendelson, 1993). Both clinical and human laboratory studies utilizing buprenorphine also offer conflicting results (Kosten, Kleber, & Morgan, 1989a, 1989b; Kosten, Schottenfeld, Morgan, Falcioni, & Ziedonis, 1992; Mendelson, Teoh, Mello, & Ellingboe, 1992; Strain, Stitzer, Liebson, & Bigelow, 1994; Teoh et al, 1992). In rats, buprenorphine increases activity of dopaminergic neurons in the ventral tegmental area (Grant & Sonti, 1994) and extracellular dopamine in the nucleus accumbens (Brown et al, 1991), effects similar to those produced by cocaine (Koob & Bloom, 1988).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Interaction of buprenorphine with cocaine-morphine combinations.

Foltin¹,

Fischman²

1995

Experimental and Clinical Psychopharmacology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Interaction of buprenorphine with cocaine-morphine combinations.

Foltin¹,

Fischman²

1995

Experimental and Clinical Psychopharmacology

View full text Add to dashboard Cite

show abstract

Moderate- vs High-Dose Methadone for Opioid Dependence

Grabowski¹

1999

JAMA: The Journal of the American Medical Association

View full text Add to dashboard Cite

The long-term outcomes of drug use by methadone maintenance patients

Bovasso

Cacciola

2003

The Journal of Behavioral Health Services & Research

View full text Add to dashboard Cite

The aim of the study is to predict long-term outcomes of methadone maintenance (MM), other than continued heroin use, on the basis of drug use occurring early in MM treatment. In previous research, the weak association of initial drug use during MM with measures of rehabilitation status may be due to the use of measures that do not differentiate trends in different types of drug use. In the present study, 222 patients who completed 6 months of MM were assessed at program intake, evaluated for opiates and cocaine in the first 6 months of treatment, and given a follow-up assessment 2 years after treatment entry. The intake status of the patients was assessed using the Addiction Severity Index. Opiate and cocaine use during the first 6 months of MM was assessed by urine toxicology. Outcomes were assessed using a structured interview and official criminal records at follow-up. Cluster analysis of urine toxicologies during treatment identified 3 trajectory classes of MM patients: (A) variably high levels of opiate use, but consistently low cocaine use; (B) low and diminishing opiate and cocaine use; and (C) consistently high cocaine use, with diminishing opiate use. In an 18-month period, after these trends were observed, Cluster C had significantly more criminal charges than Cluster B had (3 times as many), but not significantly more than those of Cluster A. Clusters A and B did not differ significantly in criminal charges. Regardless of cluster membership, subjects with increasing levels of cocaine use in the first 6 months of MM had more hospitalizations for drug and alcohol problems during the follow-up period than subjects without increasing levels of cocaine use had. The results provide evidence of negative sequelae of cocaine use during MM that underscore the importance of clinical efforts to reduce levels of cocaine and other nonopiate drug use by MM patients.

show abstract

Outcome after methadone treatment: influence of prior treatment factors and current treatment status

Cited by 18 publications

References 23 publications

Interaction of buprenorphine with cocaine-morphine combinations.

Interaction of buprenorphine with cocaine-morphine combinations.

Moderate- vs High-Dose Methadone for Opioid Dependence

The long-term outcomes of drug use by methadone maintenance patients

Contact Info

Product

Resources

About