Outcome after fixation of metastatic proximal femoral fractures: A systematic review of 40 studies

Janssen, Stein J.; Teunis, Teun; Hornicek, Francis J.; Dijk, C. Niek van; Bramer, Jos A. M.; Schwab, Joseph H.

doi:10.1002/jso.24345

Cited by 41 publications

(45 citation statements)

References 85 publications

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“…Reconstruction with a (modular or custom) proximal femoral endoprosthesis (tumor prosthesis) or an allograft‐prosthesis composite are the two main alternatives . Other surgical options, such as intramedullary nailing without tumor resection, can be used for palliative treatment in bone metastases . However, in this study, we aimed to look at reconstructive options after tumor resection with a curative intent or resection aiming for local control of the disease.…”

Section: Introductionmentioning

confidence: 99%

Outcome after reconstruction of proximal femoral tumors: A systematic review

Janssen

Langerhuizen

Schwab

et al. 2018

Journal of Surgical Oncology

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Tumor resection followed by reconstruction with a proximal femoral endoprosthesis or an allograft-prosthesis composite are the two main alternatives for treatment of proximal femoral malignancies. This review describes the revision rate, implant survival, limb salvage rate, and function. Overall revision rates are high and reasons for failure differ between treatment modalities. Rate and reasons for amputation are comparable between both methods. Functional outcome was reasonable to good on average for both treatment modalities. Level of evidence: IV, systematic review and meta-analysis. K E Y W O R D S allograft, benign, cancer, femoral, femur, malignant, prosthesis, proximal, reconstruction, replacement, tumor SUPPORTING INFORMATION Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Janssen SJ, Langerhuizen DWG, Schwab JH, Bramer JAM. Outcome after reconstruction of proximal femoral tumors: A systematic review. J Surg Oncol.

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Section: Introductionmentioning

confidence: 99%

Outcome after reconstruction of proximal femoral tumors: A systematic review

Janssen

Langerhuizen

Schwab

et al. 2018

Journal of Surgical Oncology

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“…Мы объясняем это тем, что в структуре первичных злокачественных опухолей кости в нашем исследовании превалирующей была хондросаркома кос ти G2 (87,5%), а в группе с метастатическим поражением кости -рак молочной железы (63%) и рак почки (19,5%). Вышеуказанные нозологии наиболее благоприятны для пациентов с точки зрения прогноза выживаемости [3,4,7,22].…”

Section: Discussionunclassified

The Long-Term Results of Hip Arthroplasty in Patients with Proximal Femur Tumors

Микайлов¹,

Тихилов

Пташников

et al. 2020

Traumatology and Orthopedics of Russia

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Relevance. The development of the modern principles of combined tumor treatment has significantly improved the survival of the patients. For these patients, the organ-preserving surgerybecomes now the mainstream tactics. For the restoration of the lower limb support ability and the hip function, the hip arthroplasty is now the most used type of surgery. Purpose of the study. The purpose of this work was to evaluate the long-term results of hip arthroplasty in the patients with extensive proximal femur defects caused by tumors and tumor-like lesions. Materials and Methods. The data on 126 patients with proximal femur tumors, undergone the surgical treatment in 2000-2013, were collected and summarized. The average age of the patients was 53.8 years (26-74), 94 women (74.6%), and 32 men (25.4%). There were 16 primary malignant bone tumors (12.7%), 10 benign aggressive (7.9%); 92 metastatic (73%), and 8 tumor-like lesions (6.4%). The average follow-up after the surgery was 72.6 months. The complications classification and analysis were performed according to the criteria of the International Society of Limb Salvage 2014 (ISOLS 2014). For the assessment of the functional result, patients were divided into 4 groups. In this context, the following indicators were taken into account: whether the acetabular component or the bipolar head were used, and the method of the soft tissues fixation to the femoral component of the endoprosthesis. Functional outcome was evaluated using the international Musculoskeletal Tumor Society (MSTS) scoring system at 3, 6, and 12 months. Results. The total number of complications, identified during the observation period from 2000 to 2018, was 26 (20.6%). The oncological complications, represented by local recurrence, were detected on average after 11.5 months. The total number of local recurrences is 6 (4.7%) which amounted to 23% in the structure of all complications. Dislocations of the endoprosthesis became the most frequent complication-13 (10.3%) observations, 50% in the structure of all complications. Only one patient with aseptic instability of the femoral component was identified over the entire follow-up period. There were 4 (3.1%) patients with complications due to the destruction of metal constructions. All of them had an endoprosthesis stem fracture. The average period of onset of these complications was 122.5 months. Prosthetic joint infection was observed in 2 (1.6%) patients (7.2% of all complications), on the 14th and 31st days. The patient with the latter onset of infection underwent a twostaged revision arthroplasty. Functional result by the MSTS scale: 3 months-74.8%, 6 months-79%, 12 months-81.8%. In the patients under investigation, 5-, 10-, and 15-year survival for aggressive benign tumors and tumorlike lesions was 95%, 84%, 62%; for malignant primary tumors-88%, 65%, 24%; for secondary bone lesions-55%, 43%, 12%, respectively. Conclusion. The use of a bipolar head made it possible to reduce the likelihood of an endoprosthesis dislocation. The fixation of the preserved...

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“…Patient reported outcome data from patients with bone metastasis are scarce . We assessed physical function and pain intensity in a cross sectional sample of patients with symptomatic bone metastases.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, the assessment of physical function, pain intensity, and quality of life have become important in gauging the effectiveness of any given treatment. However, data on patient‐reported outcome measures, such as physical function and pain intensity, in patients with bone metastatic diseases are scarce . Normative data on patients with symptomatic bone metastasis could help us interpret the results of similar patient groups in the future.…”

Section: Introductionmentioning

confidence: 99%

Physical function and pain intensity in patients with metastatic bone disease

Janssen

Pereira

Thio

et al. 2019

Journal of Surgical Oncology

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Background Patient reported outcome data in bone metastatic disease are scarce and it would be useful to have normative data and understand what patients are at risk for poor function and more pain. Objectives We aimed to assess what factors are independently associated with physical function and pain intensity in patients with bone metastasis. Methods We included data from 211 patients with bone metastasis who completed a survey (2014‐2016) including the PROMIS Physical Function Cancer and PROMIS Pain Intensity questionnaires. Results Prostate (P < .001) and thyroid carcinoma (P = .007) were associated with better function and having other disabling conditions (P = 0.035) was associated with worse function. Prostate carcinoma (P = .001) and lymphoma (P = .007) were associated with less pain. There was a moderate correlation between pain and function (P < .001). Function was substantially worse as compared to a US reference population of patients with cancer (P < .001), whereas pain was slightly less compared to the US general population average (P < .001). Conclusions Patients with bone metastasis have a poor physical function. Physical function and pain intensity depend on tumor histology, but also on potentially modifiable factors such as other disabling conditions. Level of Evidence Level III, prognostic study.

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Outcome after fixation of metastatic proximal femoral fractures: A systematic review of 40 studies

Cited by 41 publications

References 85 publications

Outcome after reconstruction of proximal femoral tumors: A systematic review

Outcome after reconstruction of proximal femoral tumors: A systematic review

The Long-Term Results of Hip Arthroplasty in Patients with Proximal Femur Tumors

Physical function and pain intensity in patients with metastatic bone disease

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