Outcome after cardiac arrest: predictive values and limitations of the neuroproteins neuron-specific enolase and protein S-100 and the Glasgow Coma Scale

Pfeifer, Rüdiger; Börner, A.; Krack, Andreas; Sigusch, Holger H.; Surber, Ralf; Figulla, Hans R.

doi:10.1016/j.resuscitation.2004.10.011

Cited by 131 publications

(107 citation statements)

References 31 publications

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“…315 Other less robust studies show similar high specificity with low sensitivity. 319,320,[323][324][325][326] Although a recommendation has been made on the use of biochemical markers, specifically NSE Ͼ33 g/L, as a predictor of poor outcome, 254 care must be taken. This caution is based on problems such as lack of standardization in study design and patient treatment, the wide variability of threshold values to predict poor outcome, and differing measurement techniques.…”

Section: Biochemical Markersmentioning

confidence: 99%

Post–Cardiac Arrest Syndrome

Neumar¹,

Nolan²,

Adrie³

et al. 2008

Circulation

1,210

392

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Section: Biochemical Markersmentioning

confidence: 99%

Post–Cardiac Arrest Syndrome

Neumar¹,

Nolan²,

Adrie³

et al. 2008

Circulation

1,210

392

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“…Isso parece ser o resultado de uma lesão encefálica mais extensa e persistente nos não sobreviventes. A duração da anóxia foi significativamente mais prolongada no grupo dos não sobreviventes, o que novamente sugere a existência de uma correlação entre a extensão da lesão encefálica com os níveis de NSE 34 . Nos resultados de Meynaar e col., os níveis de NSE foram mais elevados em pacientes que não recuperaram a consciência.…”

Section: A Enolase Específica Do Neurôniounclassified

Valor da enolase específica do neurônio como indicador de prognóstico pós-parada cardiorrespiratória

Rech¹,

Vieira²,

Brauner³

2006

Rev. bras. ter. intensiva

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RESUMO JUSTIFICATIVA E OBJETIVOS: A parada cardíaca é um estado de grave hipoperfusão cerebral. Os pacientes que sobrevivem a uma reanimação cardiorrespiratória estão sob grande risco de vir a morrer ou desenvolver lesão cerebral incapacitante, inclusive estado vegetativo persistente. Uma definição precoce do prognóstico desses pacientes tem implicações éticas e econômicas. O objetivo desse estudo foi revisar o valor prognóstico da Enolase Específica do Neurônio (NSE) em predizer precocemente os desfechos de pacientes após uma parada cardíaca. CONTEÚDO: A lesão cerebral permanente é a complicação mais temida de uma reanimação cardíaca prolongada. Muitos estudos têm tentado isolar fatores prognósticos que possam estar associados com desfechos clínicos em pacientes sobreviventes de parada cardíaca. Indicadores bioquímicos de morte neuronal parecem promissores nesse cenário. Nesse contexto, a NSE vem sendo estudada em pacientes reanimados de paradas cardíacas e níveis elevados dessa enzima

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“…Increased level of NSE is a sensitive and specific marker of neuronal injury. NSE level is correlated with the size of cerebral infarct and Glasgow coma scale (16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Cardio-ankle vascular index may be an important marker of silent neuronal injury after percutaneous coronary angiography and intervention: a prospective observational study on diagnostic accuracy

Aykan¹,

Gökdeniz²,

Bektaş³

et al. 2014

Anadolu Kardiyol Derg

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Objective: The relationship between silent neuronal injury (SNI) and arterial stiffness assessed by cardio-ankle vascular index (CAVI) has not been evaluated in patients treated with coronary angiography and intervention due to acute coronary syndrome (ACS). The aim of this study is to evaluate the value of CAVI in prediction of SNI after percutaneous coronary angiography and intervention in patients presented with ACS. Methods: Eighty-three consecutive patients presented with ACS, who underwent percutaneous coronary angiography and intervention, were included in this prospective observational study on diagnostic accuracy. Neuron specific enolase (NSE) was studied before and 18 hour after the coronary angiography and intervention. CAVI was measured by VaSera-1000 instrument. Clinical and echocardiographic characteristics were analyzed and independent predictors of SNI were evaluated. Chi-square, Student t-test, Mann-Whithney U test, correlation analysis and logistic regression analysis was used for statistical analysis. Results: NSE levels significantly increased after cardiac catheterization (9.82±3.22 mg/dL vs. 13.15±8.55 mg/dL, p<0.001). CAVI (OR=2.992, 95% CI: 1.494-5.713, p=0.002), left ventricular ejection fraction (LVEF) (OR=0.911, 95% CI: 0.843-0.983, p=0.017) and undergoing percutaneous coronary intervention (OR=4.430, 95% CI: 1.034-18.97, p=0.045) were the independent predictors of SNI in logistic regression analysis. The cut-off value to show SNI for CAVI was 10.45 (sensitivity=71.8%, specificity=91.5%) in receiver operator charecteristic (ROC) curve analysis. The area under curve was 0.832 (95% CI=0.746-0.918, p<0.001). Conclusion: Besides undergoing PCI and having LVEF, measurement of CAVI may be a useful tool for predicting the development of SNI after percutaneous coronary angiography and intervention in patients with ACS. (Anadolu Kardiyol Derg 2014; 14: 606-11)

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Outcome after cardiac arrest: predictive values and limitations of the neuroproteins neuron-specific enolase and protein S-100 and the Glasgow Coma Scale

Cited by 131 publications

References 31 publications

Post–Cardiac Arrest Syndrome

Post–Cardiac Arrest Syndrome

Valor da enolase específica do neurônio como indicador de prognóstico pós-parada cardiorrespiratória

Cardio-ankle vascular index may be an important marker of silent neuronal injury after percutaneous coronary angiography and intervention: a prospective observational study on diagnostic accuracy

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