Outbreaks of a Methicillin-ResistantStaphylococcus aureusClone ST398-t011 in a Hungarian Equine Clinic: Emergence of Rifampicin and Chloramphenicol Resistance After Treatment with These Antibiotics

Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing

“…This high percentage of ST8-associated MRSA is similar to veterinary hospital cases from the northeastern United States, Ohio, and Canada attributed to USA500 as well as infections observed at French stud farms ( 8 , 50 – 52 ). However, while previous studies with European horses found the porcine-associated ST398 to be a predominant clone ( 53 – 55 ), only two of the MRSA isolates in this study were ST398. The most common clonal complex in our study CC8 is one of the most frequently identified and associated with MRSA in horses ( 32 ).…”

“…The high level of phenotypic resistance to penicillin and tetracycline in the isolates is similar to previous reports in S. aureus from horses in Canada and Europe ( 8 , 66 ). However, the percentage of gentamicin-, TMS-, and rifampin-resistant isolates in the collection is higher than the zero resistance prevalence observed in one report from Canada but lower than reports from French stud farms and a Hungarian clinic ( 8 , 53 , 66 ). Macrolide resistance was seen in 10 isolates.…”

Methicillin-Resistant Staphylococcus aureus Strains in Swiss Pigs and Their Relation to Isolates from Farmers and Veterinarians

“…This observation is corroborated by the phylogenetic analyses clustering all but one veterinary isolate with horse strains. Contact with horses is a known risk factor for MRSA transmission to veterinary personnel (14,34). Recent studies in other European countries also found ST398-t011 to be the dominant type in horses (14,33), while older studies found other types, mainly CC8 (35).…”

“…Contact with horses is a known risk factor for MRSA transmission to veterinary personnel (14,34). Recent studies in other European countries also found ST398-t011 to be the dominant type in horses (14,33), while older studies found other types, mainly CC8 (35). Abdelbary et al (36) looked into the phylogeny of horseassociated LA-MRSA strains from different countries and found a CC398 subclone associated with equine hospitals.…”

“…Furthermore, LA-MRSA can be found in horses, veal calves, and poultry (1). In horses, LA-MRSA can also be an agent of nosocomial infection in an animal clinic environment and can be transmitted to clinical staff in this context (13,14).…”