Outbreak of tularaemia in Castilla y León, Spain

Martín, Carmen González; Gallardo, M T; Mateos, L; Vián, E; Garcia, Melissa; Ramos, Jordão Raphael Fujii; Berjón, A C; Viña, M.; Garcia, M. P. Romero; Yanez, J Pena; González, Lester; Muñoz, Tomás; Allué, Miguel; Andrés, Cristina; Ruiz, C; Castrodeza, J.

doi:10.2807/esw.12.45.03302-en

Cited by 21 publications

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“…In a previous study that included strains from the 1997–1998 tularemia outbreak in Spain, the specific M24 allele and the RD23 deletion were found in 49 of 49 strains from Spain and France but in only 1 of 189 strains from 7 northern and eastern European countries and Japan ( 3 ). The tularemia outbreak of 1997–1998 in Spain, which resulted in >500 human cases ( 5 ), was thus caused by F. tularensis strains that were genetically closely related to strains recovered in Switzerland from 1996 onwards, before the beginning of the outbreaks in Spain. This genetic relationship shows that factors other than the presence or introduction of a specific clone of the infectious agent per se determined the magnitude of the tularemia outbreaks in Spain.…”

Section: Discussionmentioning

confidence: 99%

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Identification ofFrancisella tularensisCluster in Central and Western Europe

Pilo¹,

Johansson²,

Frey³

2009

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

“…During the past 15 years, the reemergence of tularemia has been reported in several European countries ( 2 – 4 ). Spain is a notable example, reporting 916 human infections from 1997 through 2007 in the Castilla and León regions alone ( 5 ). However, tularemia is rarely diagnosed in central Europe.…”

mentioning

confidence: 99%

Identification ofFrancisella tularensisCluster in Central and Western Europe

Pilo¹,

Johansson²,

Frey³

2009

Emerg. Infect. Dis.

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“…In Spain, ulceroglandular tularemia in human was first observed in 1998 [13]. In 2007 the second outbreak in the same region was with typhoid form predominance [14]. However, oropharyngreal tularemia is the most frequently observed type in some eastern European countries, particularly in Kosovo, Turkey, and Bulgaria [6,7,15].…”

Section: Discussionmentioning

confidence: 99%

Tularemia in Bulgaria 2003-2004

Komitova

Nenova

Padeshki

et al. 2010

J Infect Dev Ctries

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Introduction: Tularemia is an uncommon but potentially fatal zoonosis. А second outbreak of tularemia in Bulgaria, about 40 years after the first, occurred in 1997 in two western regions, near the Serbian border. In 2003 tularemia reemerged in the same foci. This retrospective study aimed to evaluate the clinical characteristics and the efficacy of antibiotic therapy in a tularemia resurgence in the Slivnitza region in [2003][2004]. Methodology: A total of 26 cases were evaluated. Using medical records, the following data were collected for all patients: symptoms, physical signs, and microbiology results of agglutination tests, cultures and PCR assays. Results: Twenty-four of 26 suspected tularemia patients were laboratory confirmed by agglutination test and/or culture. Fifteen (57.7%) patients had clinical presentation compatible with oropharyngeal, 8 (30.8%) with glandular, and 3 (11.5%) with oculoglandular tularemia. The most frequent symptoms were swollen neck (84.6%) and sore throat (76.9%). Lymphadenopathy (100%) was the most common finding. Francisella tularensis (F. tularensis) was detected by PCR, providing a definitive diagnosis in 82.3% of the cases. All the patients were treated with antibiotics considered effective against F. tularensis; however, therapeutic failure was observed in 23.1% of the cases, which was related to a delay in the initiation of antibiotics. Conclusion: The tularemia outbreak in west Bulgaria near the Serbian border was probably food-borne, associated with a surge in the rodent population. The oropharyngeal form was the most common. Although the disease runs a benign course, late initiation of antimicrobial therapy might delay complete recovery.

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“…In recent years, epidemiology of human tularemia has changed considerably on the Eurasian continent: whereas a sharp decline of cases has been observed in many areas since the end of World War II (e.g. in Russia), an increasing number of tularemia outbreaks has been described in non-endemic areas during the past decade, such as in Kosovo (1999Kosovo ( -2000Kosovo ( , 2003, Turkey (2005Turkey ( -2007 and Spain (1997,1998,2007) [6,17].…”

Section: Epidemiological Aspects Of Tularemia In Europementioning

confidence: 99%

Oropharyngeal tularemia – a differential diagnosis of tonsillopharyngitis and cervical lymphadenitis

Dlugaiczyk

Harrer

Zwerina

et al. 2010

Wien Klin Wochenschr

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Francisella tularensis, the causative agent of tularemia, has been recognized as a human and zoonotic pathogen for almost 100 years. The increasing number of tularemia outbreaks in regions of Europe outside the classic endemic areas in recent years has prompted renewed interest in this rare infectious disease. We report on a case of oropharyngeal tularemia in an 18-year-old girl from Bavaria (Germany) who presented with tonsillopharyngitis and cervical lymphadenitis. Strongly positive serological tests and PCR detection of F. tularensis subsp. holarctica in lymph node tissue led to the diagnosis of tularemia. After long-term treatment with doxycycline, partly in combination with ciprofloxacin, the patient recovered completely. Clinical presentation, diagnostics, treatment and recent epidemiological aspects of tularemia in Europe are discussed in this case report and review of the literature.

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Outbreak of tularaemia in Castilla y León, Spain

Cited by 21 publications

References 0 publications

Identification ofFrancisella tularensisCluster in Central and Western Europe

Identification ofFrancisella tularensisCluster in Central and Western Europe

Tularemia in Bulgaria 2003-2004

Oropharyngeal tularemia – a differential diagnosis of tonsillopharyngitis and cervical lymphadenitis

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