Outbreak of Tuberculosis Caused by <i>Mycobacterium caprae</i> in a Zoological Garden

Pate, Mateja; Švara, Tanja; Gombač, Mitja; Paller, Tomislav; Žolnir-Dovč, Manca; Emeršič, I.; Prodinger, Wolfgang M.; Bartoš, Milan; Zdovc, Irena; Krt, B.; Pavlík, I.; Cvetnić, Željko; Pogačnik, M.; Ocepek, M.

doi:10.1111/j.1439-0450.2006.01000.x

Cited by 29 publications

(15 citation statements)

References 30 publications

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“…In dromedary camels, M. tuberculosis (Elmossalami et al, 1971;Zubairet al, 2004), M. bovis (Kinne et al, 2006), M. capre (Pate et al, 2006) and M. microti have been isolated from tissue lesions (Wernery and Kaaden, 2002;Kinne et al, 2006). M. bovis strains were also isolated by Donchenko et al (1975) in Russia from bulked samples of raw dromedary milk.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of bovine tuberculosis in dromedary camels and awareness of pastoralists about its zoonotic importance in Eastern Ethiopia

Beyi¹,

Gezahegne²,

Mussa³

et al. 2014

J. Vet. Med. Anim. Health

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The aim of this study was to investigate bovine tuberculosis in camels which was conducted in Eastern part of Ethiopia using post mortem examination, Mycobaterium isolation, tuberculin skin test and questionnaire based interview. Tuberculosis (TB) is an important disease for pastoralist, particularly due to prevailing habit of consuming raw milk and sharing house during night time with their animals. This study has showed prevalence rate of 8.3% (33/398) based on the post mortem examination and 6.0% (29/480) at cut off >4 mm based on the tuberculin test. From 33 camels with suspected tuberculosis compatible lesions, 12% (4/33) showed mycobacterial growth on Lowenstein-Jensen (LJ) media supplemented with pyruvate and 18% (6/33) on LJ media supplemented with glycerol. 94.7% (36/38) of the interviewed pastoralists knew about TB while only 50% (19/38) were aware about its zoonotic importance. However, only 18.4% (7/38) of the interviewed camel owners usually boil camel milk before consumption. The result of this study highlights the potential public health risk posed by TB from camels. Hence, prompt measures are required to control the possible zoonotic transmission of the disease-prioritizing on educating the pastoralist to consume camel milk after boiling.

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Section: Introductionmentioning

confidence: 99%

Prevalence of bovine tuberculosis in dromedary camels and awareness of pastoralists about its zoonotic importance in Eastern Ethiopia

Beyi¹,

Gezahegne²,

Mussa³

et al. 2014

J. Vet. Med. Anim. Health

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“…M. microti and M. cannettii have been described much earlier, but were for a long time believed to be pathogenic in murines and humans, respectively. Recent reports have shown that some of these organisms can infect and cause disease in other species as well and the full host range still needs to be defined (Aranaz et al 2003;van Ingen et al 2012;Alexander et al 2010;Dawson et al 2012;Hansen et al 2012;Pate et al 2006;Kiers et al 2008;Goh et al 2006;Mostowy et al 2004). …”

Section: Causative Agents Of Tuberculosis In Human and Animal Hostsmentioning

confidence: 96%

Zoonotic Aspects of Tuberculosis: Disease of the past or re-emerging zoonosis?

Michel

2014

Zoonoses - Infections Affecting Humans and Animals

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Tuberculosis is a serious chronic disease of humans and animals caused by members of the Mycobacterium tuberculosis complex. While M. tuberculosis affects primarily humans, Mycobacterium bovis has a wide range of host species including wild and domestic animals and humans. This chapter investigates the role of different host species in the transmission of tuberculosis at various animal/human interfaces. While drivers and modes of zoonotic TB transmission are reviewed, a broad spectrum of complexities hampering the eradication of this disease are highlighted. The most important constraints, next to factors related to pathogen-host interactions such as HIV co-infection and multidrug resistance of MTBC strains, are socio-economic shortcomings in the control of bovine tuberculosis in the cattle population as well as traditional customs and habits related to the consumption of milk and other animal products.

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“…Among the MTC mycobacteria, Mycobacterium bovis is likely to be the one with the more relevant zoonotic burden (Cosivi et al , 1998). Mycobacterium tuberculosis (Sternberg Lewerin et al , 2005), M. bovis (Stetter et al , 1995), Mycobacterium pinnipedii (Moser et al , 2008), Mycobacterium caprae (Pate et al , 2006) and Mycobacterium microti (Pattyn et al , 1970; A. Lécu, unpubl. data) are examples of known zoonotic MTC mycobacteria already reported within zoological collections, whereas ‘dassie bacillus’ was found in Meerkats Suricata suricatta and hyraxes Procavia sp but never reported in humans.…”

Section: Transmission and Zoonotic Risk From Zoo Animalsmentioning

confidence: 99%

Mycobacterial infections in zoo animals: relevance, diagnosis and management*

Lécu¹,

Ball²

2011

International Zoo Yearbook

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While the world prevalence of tuberculosis (TB) is increasing in the human population, TB infection remains a real concern in some animal populations all around the globe. Most mycobacteria of the TB complex are able to infect zoo and wildlife species, in which the pathogenesis, receptivity and immune responses vary widely. The diagnostic tools usually applied in domestic animals show limited performance in zoo species, especially when prevalence is low. Conversely, investigations of cell‐mediated immunity through in vitro assay of γ‐interferon may have numerous advantages, as long as the technical limits are known and can be improved upon. Furthermore, recent tools based on the investigation of humoral immunity seem very promising for the detection of antibodies directed against certain immunogenic mycobacterial antigens in a wide range of species. All these methods are currently evaluated in field studies, despite the difficulties to ensure rigorous validation. The development of these diagnostic tools is also impaired by the prevalence of mycobacteria other than TB also able to infect and create relevant disease in their host. Thus, decisions on positive and suspicious‐animals issues should be taken based on the evaluation of the risk of transmission to the rest of the zoological collection, the possible treatment options, animal welfare, conservation considerations and, of course, the zoonotic potential of this pathogen.

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Outbreak of Tuberculosis Caused by Mycobacterium caprae in a Zoological Garden

Cited by 29 publications

References 30 publications

Prevalence of bovine tuberculosis in dromedary camels and awareness of pastoralists about its zoonotic importance in Eastern Ethiopia

Prevalence of bovine tuberculosis in dromedary camels and awareness of pastoralists about its zoonotic importance in Eastern Ethiopia

Zoonotic Aspects of Tuberculosis: Disease of the past or re-emerging zoonosis?

Mycobacterial infections in zoo animals: relevance, diagnosis and management*

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