“…Pioneer work on the use of fingerprinting for tracing outbreaks detected an epidemic among homeless people in Amsterdam, identified two persons contaminated during bronchoscopy on the same day in the same clinic, demonstrated that a woman contaminated her husband and showed transmission within certain families in Czechoslovakia , identified sources of infection in a pub and a discotheque (Van Embden et al 1993b) and demonstrated infection by a neighbor (GodfreyFaussett et al 1992a). The importance of transmission of TB within shelters for the homeless was also demonstrated in a study with TB patients from Australia and by means of contact investigation by IS6110-RFLP, it was shown that TB was actively transmitted in a neighborhood bar in Minneapolis, where an index case infected 41 of his contacts (Kline et al 1995). These studies clearly demonstrate the value of RFLP analysis in situations where traditional contact tracing alone would not be able to detect clusters of TB; it also shows that single, highly infectious cases can have a severe influence on TB transmission within a community and, as a consequence, on TB programs.…”