Outbreak of Severe Respiratory Disease Associated with Emergent Human Adenovirus Serotype 14 at a US Air Force Training Facility in 2007

Tate, Jacqueline E.; Bunning, Michel L.; Lott, Lisa; Lu, Xiaoyan; Su, John R.; Metzgar, David; Brosch, Lorie C.; Panozzo, Catherine A.; Marconi, Vincent C.; Faix, Dennis J.; Prill, Mila M.; Johnson, Brian D.; Erdman, Dean D.; Fonseca, Vincent P.; Anderson, Larry J.; Widdowson, Marc‐Alain

doi:10.1086/598520

Cited by 118 publications

(123 citation statements)

References 31 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…However, the low rate of infections (5%) observed by Esposito et al ( 11 ) in household contacts of persons infected with the emerging virus suggests that infection is unlikely to spread in the community. Efficient transmission of HAdV-14p1 appears to require close physical contact, as supported by the observation that in barracked communities used for military trainees in the United States, antibody titers demonstrated recent exposure after entry to the facility ( 25 ). Of interest in the HAdV-14p1 cases identified in the present study is the higher frequency of male patients (78%) infected; this observation has been reported by other groups ( 19 , 26 ), although the numbers identified in our study are insufficient to make definitive conclusions.…”

Section: Discussionmentioning

confidence: 97%

Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010

Carr¹,

Kajon²,

Lu³

et al. 2011

Emerg. Infect. Dis.

Self Cite

View full text Add to dashboard Cite

Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009–July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.

show abstract

Section: Discussionmentioning

confidence: 97%

Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010

Carr¹,

Kajon²,

Lu³

et al. 2011

Emerg. Infect. Dis.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Past studies in the United States reported that adenovirus epidemics were associated with preventive interventions such as adenovirus vaccines and hand washing (8,22). However, the association of adenovirus epidemics with the types and difficulties of military training has remained uncertain in previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…All patients were young, previously healthy soldiers. Although several studies have described the clinical features of adenovirus infection among military personnel (7)(8)(9)(10)(11)(12)(13), few studies have compared the clinical characteristics of pneumonic and non-pneumonic adenovirus cases or evaluated the risk factors associated with military training courses. Furthermore, few reports have provided detailed descriptions of the radiological features of adenovirus infections by means such as thinsection computed tomography (CT) (7,9).…”

Section: Introductionmentioning

confidence: 99%

Outbreak of Febrile Respiratory Illness Caused by Adenovirus at a South Korean Military Training Facility: Clinical and Radiological Characteristics of Adenovirus Pneumonia

Hwang

Park²,

Yong³

et al. 2013

Jpn J Infect Dis

View full text Add to dashboard Cite

SUMMARY: Adenovirus often causes respiratory disease outbreaks in military training soldiers. Compared with adenovirus pneumonia in young military adults, symptoms arising from febrile respiratory illness (FRI) caused by adenovirus have not been previously evaluated in Korean soldiers. We conducted an event-based outbreak investigation involving 712 male soldiers aged 19 to 21 years from March 14 to 30, 2012 to evaluate the epidemiological and clinical characteristics of patients with pneumonia and FRI caused by adenovirus. We described the laboratory and radiological characteristics of patients with adenovirus pneumonia. Among these, 407 cases of FRI and 15 cases of pneumonia were identified through active surveillance (attack rate of FRI, 57.16z; attack rate of pneumonia, 2.11z). Fire training and march training may present environmental risk factors for adenovirus-associated outbreaks. Most symptoms were mild. The most frequent symptom in patients with pneumonia and FRI was cough. Patients with pneumonia were associated with an increased incidence of dizziness (crude odds ratio [cOR], 9.65; 95z confidence interval [CI], 2.38-37.15) and a decreased incidence of rhinorrhea (cOR, 0.15; 95z CI, 0.04-0.53) during adenovirus-associated outbreaks. Differential leukocyte count revealed high monocytes, low lymphocytes, and low eosinophils, and chest computed tomography revealed a consolidation pattern and right lobar pneumonia. These findings warrant a high level of suspicion for adenovirus pneumonia.

show abstract

“…Currently, there is no vaccine available for the civilians. However, there is a vaccine against type 4 and 7, available on the license, only for U.S. military recruits [14].…”

Section: Introductionmentioning

confidence: 99%

Genotyping of human adenoviruses circulating in Southwest India

et al. 2016

View full text Add to dashboard Cite

Adenoviruses are found to be associated with a wide range of diseases in children and adults. There is little data available on the circulating serotypes of Human Adenoviruses (HAdVs) in the southwest region of India. In this study, we explore the molecular epidemiology of HAdVs circulating in southwest India. Twenty-three samples (Adenovirus PCR positive), collected between January 2011 and March 2013, have been typed based on the partial hexon gene sequence and phylogenetic analysis. The commonest serotypes were HAdV-3 and HAdV-2. The other serotypes were HAdV-7, HAdV-1, HAdV-8 and HAdV-40. Respiratory illness was the most common clinical manifestation of HAdV-3, HAdV-2 and HAdV-7 serotypes. HAdV-3, HAdV-7 and HAdV-8 were found to cause conjunctivitis, whereas HAdV-1, HAdV-2 and HAdV-3 caused encephalitis. In conclusion, this study documents the circulating HAdV strains and the epidemiology in southwest India. To the best of our knowledge, this is the first study on the molecular epidemiology of HAdVs in India.

show abstract

Outbreak of Severe Respiratory Disease Associated with Emergent Human Adenovirus Serotype 14 at a US Air Force Training Facility in 2007

Abstract: Emergence of Ad14, a rare Ad serotype, caused a protracted outbreak of respiratory illness among military recruits. Most infected recruits experienced FRI or milder illnesses. Some required hospitalization, and 1 died. Natural Ad7 infection may protect against severe Ad14 illness.

Cited by 118 publications

References 31 publications

Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010

Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010

Outbreak of Febrile Respiratory Illness Caused by Adenovirus at a South Korean Military Training Facility: Clinical and Radiological Characteristics of Adenovirus Pneumonia

Genotyping of human adenoviruses circulating in Southwest India

Contact Info

Product

Resources

About