Outbreak of severe dengue associated with DENV-3 in the city of Manado, North Sulawesi, Indonesia

Tatura, Suryadi N. N.; Denis, Dionisius; Santoso, Marsha S.; Hayati, Rahma; Kepel, Billy J.; Yohan, Benediktus; Sasmono, R. Tedjo

doi:10.1016/j.ijid.2021.03.065

Cited by 13 publications

(15 citation statements)

References 45 publications

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“…Previous reports have pointed to an association between viral serotype replacement and increased severity or mortality due to dengue, based on descriptive temporal or spatio-temporal relationships 8 , 30 , 31 . An ecological study investigating the effects of environmental, demographic, socioeconomic and biological factors on dengue-related mortality observed an increased risk of death due to the disease when DENV2 was circulating, but the emergence and re-emergence of different serotypes were not analyzed 16 .…”

Section: Discussionmentioning

confidence: 99%

Spatio-temporal dynamics of dengue-related deaths and associated factors

Santana

Baquero

Maeda

et al. 2022

Rev. Inst. Med. trop. S. Paulo

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Since the reintroduction of dengue viruses in 1987, Sao Paulo State (SP), Brazil, has experienced recurrent epidemics in a growing number of municipalities, each time with more cases and deaths. In the present study, we investigated the spatio-temporal dynamics of dengue-related deaths and associated factors in SP. This was an ecological study with spatial and temporal components, based on notified dengue-related deaths in the municipalities of SP between 2007 and 2017. A latent Gaussian Bayesian model with Poisson probability distribution was used to estimate the standardized mortality ratios (SMR) for dengue and relative risks (RR) for the socioeconomic, demographic, healthcare-related, and epidemiological factors considered. Epidemiological factors included the annual information on the number of circulating serotypes. A total of 1,019 dengue-related deaths (0.22 per 100,000 inhabitant-years) between 2007 and 2017 were confirmed in SP by laboratory testing. Mortality increased with age, peaking at 70 years or older (1.41 deaths per 100,000 inhabitant-years). Mortality was highest in 2015, and the highest SMR values were found in the North, Northwest, West, and coastal regions of SP. An increase of one circulating serotype, one standard deviation in the number of years with cases, and one standard deviation in the degree of urbanization were associated with increases of 75, 35, and 45% in the risk of death from dengue, respectively. The risk of death from dengue increased with age, and the distribution of deaths was heterogeneous in space and time. The positive relationship found between the number of dengue serotypes circulating and years with cases at the municipality/micro-region level indicates that this information can be used to identify risk areas, intensify surveillance and control measures, and organize healthcare to better respond to this disease.

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Section: Discussionmentioning

confidence: 99%

Spatio-temporal dynamics of dengue-related deaths and associated factors

Santana

Baquero

Maeda

et al. 2022

Rev. Inst. Med. trop. S. Paulo

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“…2,3 Manifestasi klinis DBD sangat beragam, mulai dari gejala utama demam, mual muntah, nyeri perut, nyeri kepala, permeabilitas kapiler meningkat, kebocoran plasma, perdarahan, trombositopenia, pembesaran hati, Angka kematian akibat demam berdarah dengue pada anak mencapai 5% dan apabila sudah berkembang menjadi sindrom syok dengue maka angka kematian akan meningkat hingga 30%-50%. 4,5,6 Beberapa faktor risiko yang berperan dalam timbulnya penyakit berdasarkan segitiga epidemiologi yaitu faktor manusia (host), faktor agen, dan faktor lingkungan. Faktor manusia (host) yaitu antara lain status nutrisi diduga menjadi salah satu faktor yang dapat memengaruhi tingkat keparahan infeksi dengue.…”

Section: Pendahuluanunclassified

Hubungan antara Status Nutrisi dengan Tingkat Keparahan Infeksi Dengue pada Pasien Anak di RSUP Prof. Dr. R. D. Kandou, Manado, Indonesia

Naiem¹,

Rompies²,

Tatura³

2022

eCL

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Dengue infection is a viral disease that is transmitted through mosquitoes, especially the Aedes aegypti species infected by dengue virus. Nutritional status is thought to be one of the factors that can affect the severity of dengue infection. This study aimed to determine the relationship between nutritional status and the severity of dengue infection in pediatric patients at Prof. Dr. R. D. Kandou Hospital Manado. This was an observational and analytical study with a case control design using secondary data of the medical record of Pediatric Department at Prof. Dr. R. D. Kandou Hospital. Samples were taken using the purposive sampling technique. The results obtained a total sample of 332 samples that matched the inclusion criteria. Data were analyzed using the Chi-Square test with Jamovi 1.6.23 for Windows program resulting in a p-value of 0.205 (p>0.05) for the relationship between nutritional status and the severity of dengue infection in the pediatric patients. In conclusion, there is no relationship between nutritional status and the severity of dengue infection in pediatric patients at Prof. Dr. R. D. Kandou Hospital, Manado.Keywords: dengue infection; nutritional status; children Abstrak: Infeksi dengue merupakan penyakit virus yang penularannya melalui perantara gigitan nyamuk terutama spesies Aedes aegypti yang terinfeksi oleh virus dengue. Status nutrisi diduga menjadi salah satu faktor yang dapat memengaruhi tingkat keparahan infeksi dengue. Penelitian ini bertujuan untuk mengetahui hubungan antara status nutrisi dengan tingkat keparahan infeksi dengue pada pasien anak di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah analitik observasional dengan rancangan case control menggunakan data sekunder dari Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado. Sampel diambil menggunakan teknik purposive sampling, Hasil penelitian mendapatkan total sampel sebanyak 332 sampel yang sesuai dengan kriteria inklusi. Data penelitian dianalisis menggunakan uji Chi-Square dengan program Jamovi 1.6.23 for Windows yang mendapatkan nilai p=0,205 (p>0,05) untuk hubungan antara status nutrisi dengan tingkat keparahan infeksi dengue pada pasien anak di RSUP Prof. Dr. R. D. Kandou Manado. Simpulan penelitian ini ialah tidak terdapat hubungan bermakna antara status nutrisi dengan tingkat keparahan infeksi dengue pada pasien anak di RSUP Prof. Dr. R. D. Kandou Manado,Kata kunci: infeksi dengue; status nutrisi; anak

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“…As one of the oldest strains known, DENV-2 is more prevalent in causing severe dengue (DHF/DSS) and epidemics than other serotypes [4,10,11]. However, in several areas, DENV serotypes inducing severe infection started to shift to DENV-1, as reported in Singapore [12] and Indonesia [13]. Regarding the different subtypes of DENV, the American subtype is less likely to cause DHF/DSS than the Asian subtype.…”

Section: Dengue Pathogenesismentioning

confidence: 99%

IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis

Nanda

Jhan

et al. 2021

Journal of Immunology Research

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Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin- (IL-) 18, similar to IL-1β, is a proinflammatory cytokine produced during inflammation following inflammasome activation. Inflammatory stimuli, including microbial infections, damage signals, and cytokines, all induce the production of IL-18. High serum IL-18 is remarkably correlated with severely ill dengue patients; however, its possible roles have been less explored. Based on the clinical and basic findings, this review discusses the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression based on existing findings and related past studies.

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Outbreak of severe dengue associated with DENV-3 in the city of Manado, North Sulawesi, Indonesia

Cited by 13 publications

References 45 publications

Spatio-temporal dynamics of dengue-related deaths and associated factors

Spatio-temporal dynamics of dengue-related deaths and associated factors

Hubungan antara Status Nutrisi dengan Tingkat Keparahan Infeksi Dengue pada Pasien Anak di RSUP Prof. Dr. R. D. Kandou, Manado, Indonesia

IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis

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