Outbreak of neonatal septicemia with multidrug resistantKlebsiella Pneumoniae

Banerjee, Mohua; Sahu, K M; Bhattacharya, S.; Adhya, Sati; Bhowmick, Prolay Kumar; Chakraborty, Pitbaran

doi:10.1007/bf02860501

Cited by 18 publications

(12 citation statements)

References 5 publications

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“…It can also be present as colonizers on the hands of the health care workers. There are also frequent reports of neonatal septicemia outbreaks due to Klebsiella pneumoniae in nursery and NICUs [20]. In the present study, the authors observed an outbreak of ESBL producing Klebsiella pneumoniae during May-June 2006.…”

Section: Discussionmentioning

confidence: 85%

“…Klebsiella pneumoniae was more significantly implicated in sepsis occurring among in-born babies, while Acinetobacter species and CONS were significantly associated with out-born babies. Klebsiella pneumoniae is commonly found in the environment of the neonatal intensive care units and nursery [20]. It can also be present as colonizers on the hands of the health care workers.…”

Section: Discussionmentioning

confidence: 99%

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Neonatal Sepsis in a Tertiary Care Hospital in South India: Bacteriological Profile and Antibiotic Sensitivity Pattern

et al. 2010

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Neonatal Sepsis in a Tertiary Care Hospital in South India: Bacteriological Profile and Antibiotic Sensitivity Pattern

et al. 2010

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“…Similar observations in neonatal infections due to Klebsiella in the nursery have been reported in 1993. [8] Neonatal septicaemia due to ESBL producing K. pneumoniae was reported to produce 25% mortality. [9] Eighty percent mortality was reported during an ESBL outbreak in NICU of JIPMER, Pondicherry.…”

Section: Discussionmentioning

confidence: 99%

Nosocomial outbreak of septicaemia in neonatal intensive care unit due to extended spectrum β-lactamase producing Klebsiella pneumoniae showing multiple mechanisms of drug resistance

Rastogi¹,

Nirwan²,

Jain³

et al. 2010

Indian Journal of Medical Microbiology

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A total of 14 phenotypically similar clinical isolates of Klebsiella pneumoniae, resistant to multiple drugs including cefotaxime and ceftazidime, were isolated from blood of neonates admitted to neonatal intensive care unit (NICU) within a short span of 10 days. Alarmed at the possibility of occurrence of outbreak, a thorough investigation was done. Microbiological sampling of the NICU and labour room (LR) environment yielded 12 K. pneumoniae isolates. The presence of extended spectrum β-lactamase (ESBL) in the clinical and environmental strains was detected by double-disk synergy test (DDST), CLSI phenotypic confirmatory disk diffusion test (PCDDT) and E-test ESBL strips. Amp-C screen (disk) test was done to determine Amp-C β-lactamase production. 100% clinical strains, 57% NICU strains and 80% LR strains were ESBL positive. 57% clinical, 43% NICU and 20% LR strains were Amp-C screen positive. Polymerase chain reaction (PCR) of representative ESBL positive (10 clinical and 5 environmental) strains showed CTX gene and TEM and/or SHV gene in all. K. pneumoniae showing multiple mechanisms of drug resistance was responsible for the outbreak.

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“…[18][19][20][21][22][23][24][25][26] Infections caused by antibiotic-resistant bacteria are a particularly grave global problem27-29 not only because of the increased morbidity and mortality associated with these infections but also because they lead to increased use of expensive antimicrobial agents.…”

Section: Background and Rationalementioning

confidence: 99%

Hospital Infection Prevention and Control: A Model for Improving the Quality of Hospital Care in Low- and Middle-Income Countries

Huskins

Soule

O’Boyle

et al. 1998

Infection Control and Hospital Epidemiology

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Continuous quality improvement (CQI) is a powerful methodology for improving clinical outcomes and patient satisfaction while reducing inefficiency and costs. However, most hospitals in low- and middle-income countries have little experience with CQI methods. Hospital infection prevention is an ideal model for nascent efforts to improve the quality of hospital care because of its proven efficacy in reducing the occurrence of infections that compromise patient outcomes and increase costs. This article describes the design and implementation of a demonstration project to reduce the incidence of surgical-site infections (SSIs) for hospitals with little experience with quality-improvement methods. The project has a high likelihood of producing measurable reductions in SSI rates and hospital costs related to inefficient use of perioperative antimicrobial prophylaxis. Moreover, participating staff will gain experience that can be applied to efforts to improve the quality of other aspects of hospital care.

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Outbreak of neonatal septicemia with multidrug resistantKlebsiella Pneumoniae

Cited by 18 publications

References 5 publications

Neonatal Sepsis in a Tertiary Care Hospital in South India: Bacteriological Profile and Antibiotic Sensitivity Pattern

Neonatal Sepsis in a Tertiary Care Hospital in South India: Bacteriological Profile and Antibiotic Sensitivity Pattern

Nosocomial outbreak of septicaemia in neonatal intensive care unit due to extended spectrum β-lactamase producing Klebsiella pneumoniae showing multiple mechanisms of drug resistance

Hospital Infection Prevention and Control: A Model for Improving the Quality of Hospital Care in Low- and Middle-Income Countries

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