Outbreak of low pathogenicity H7N3 avian influenza in UK, including associated case of human conjunctivitis

Nguyen‐Van‐Tam, Jonathan S; Nair, P; Acheson, Peter; Baker, A. Cornelius; Barker, Mary; Bracebridge, Sam; Croft, Jenny; Ellis, Joanna; Gelletlie, Ruth; Gent, Nick; Ibbotson, Sue; Ca, Joseph; Mahgoub, H; Monk, Philip; Reghitt, T W; Sundkvist, T; Sellwood, C.; Simpson, John; SMITH, JEAN C.; Watson, Judith; Zambon, M; Lightfoot, N. F.; Team, Incident

doi:10.2807/esw.11.18.02952-en

Cited by 65 publications

(59 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cases of human infection by H7 influenza viruses have been reported sporadically since 1979 (51), caused by both low-and high-pathogenicity avian influenza (LPAI and HPAI, respectively) H7 viruses of the Eurasian and North American lineages. Outbreaks associated with human infections were reported in 2002 and 2003 in the United States (7,8), 2004 in Canada (7,23,49), in 1995 and 2006-2007 in the United Kingdom (1,15,27,33), in 2002 in Italy (37), and in 2003 in the Netherlands (17,25). The 2003 outbreak in the Netherlands was caused by an HPAI H7N7 subtype and was the source of infection for 89 people exposed to affected poultry, including three cases of possible human-to-human virus transmission (17).…”

mentioning

confidence: 99%

Structure and Receptor Complexes of the Hemagglutinin from a Highly Pathogenic H7N7 Influenza Virus

Yang

Carney

Donis

et al. 2012

J Virol

View full text Add to dashboard Cite

Recurrence of highly pathogenic avian influenza (HPAI) virus subtype H7 in poultry continues to be a public health concern. In 2003, an HPAI H7N7 outbreak in the Netherlands infected 89 people in close contact with affected poultry and resulted in one fatal case. In previous studies, the virus isolated from this fatal case, A/Netherlands/219/2003 (NL219) caused a lethal infection in mouse models and had increased replication efficiency and a broader tissue distribution than nonlethal isolates from the same outbreak. A mutation which introduces a potential glycosylation site at Asn123 in the NL219 hemagglutinin was postulated to contribute to the pathogenic properties of this virus. To study this further, we have expressed the NL219 hemagglutinin in a baculovirus expression system and performed a structural analysis of the hemagglutinin in complex with avian and human receptor analogs. Glycan microarray and kinetic analysis were performed to compare the receptor binding profile of the wild-type recombinant NL219 HA to a variant with a threonine-to-alanine mutation at position 125, resulting in loss of the glycosylation site at Asn123. The results suggest that the additional glycosylation sequon increases binding affinity to avian-type ␣2-3-linked sialosides rather than switching to a human-like receptor specificity and highlight the mechanistic diversity of these pathogens, which calls attention to the need for further studies to fully understand the unique properties of these viruses.

show abstract

mentioning

confidence: 99%

Structure and Receptor Complexes of the Hemagglutinin from a Highly Pathogenic H7N7 Influenza Virus

Yang

Carney

Donis

et al. 2012

J Virol

View full text Add to dashboard Cite

show abstract

“…30 A 2007 LPAI H7N3 outbreak in poultry in the United Kingdom resulted in conjunctivitis in an infected poultry worker. 31 A study of U.S. veterinarians who worked with birds reported they had significantly higher H5, H6, and H7 antibody levels than a control group. 32 These studies demonstrate the importance of protecting poultry workers when an AI outbreak in poultry is suspected or confirmed.…”

Section: Discussionmentioning

confidence: 99%

“…26,27 However, several studies indicate that workers have been infected during AI outbreaks in poultry. [27][28][29][30][31][32][33] A serological evaluation of workers exposed during the HPAI H5N1 outbreak in Hong Kong in 1997 found that approximately 3% of government workers involved in the poultry culling operation and 10% of poultry workers were seropositive. 28 During a 2003 outbreak of HPAI H7N7 in the Netherlands, infection was confirmed in 89 people, with conjunctivitis being the predominant symptom reported.…”

Section: Discussionmentioning

confidence: 99%

Protecting Poultry Workers from Exposure to Avian Influenza Viruses

et al. 2008

View full text Add to dashboard Cite

Emerging zoonotic diseases are of increasing regional and global importance. Preventing occupational exposure to zoonotic diseases protects workers as well as their families, communities, and the public health. Workers can be protected from zoonotic diseases most effectively by preventing and controlling diseases in animals, reducing workplace exposures, and educating workers. Certain avian influenza viruses are potential zoonotic disease agents that may be transmitted from infected birds to humans. Poultry workers are at risk of becoming infected with these viruses if they are exposed to infected birds or virus-contaminated materials or environments. Critical components of worker protection include educating employers and training poultry workers about occupational exposure to avian influenza viruses. Other recommendations for protecting poultry workers include the use of good hygiene and work practices, personal protective clothing and equipment, vaccination for seasonal influenza viruses, antiviral medication, and medical surveillance. Current recommendations for protecting poultry workers from exposure to avian influenza viruses are summarized in this article.

show abstract

“…Similarly, other sporadic cases of H7N3 LPAI and HPAI virus infections occurred in Canada (2004), resulting in two cases of conjunctivitis and mild respiratory symptoms. In Wales in 2007, an infection with H7N2 LPAI virus was associated with poultry obtained from a live bird market (Nguyen- Van-Tam et al 2006, Editorial team 2007. The patients had symptoms of conjunctivitis, flu-like symptoms, and neurological and gastrointestinal symptoms (Capua & Alexander 2004, Editorial team 2007.…”

Section: H7 In Humansmentioning

confidence: 99%

Avian Influenza: Public Health and Food Safety Concerns

Chmielewski

Swayne

2011

Annu. Rev. Food Sci. Technol.

View full text Add to dashboard Cite

Avian influenza (AI) is a disease or asymptomatic infection caused by Influenzavirus A. AI viruses are species specific and rarely cross the species barrier. However, subtypes H5, H7, and H9 have caused sporadic infections in humans, mostly as a result of direct contact with infected birds. H5N1 high pathogenicity avian influenza (HPAI) virus causes a rapid onset of severe viral pneumonia and is highly fatal (60% mortality). Outbreaks of AI could have a severe economic and social impact on the poultry industry, trade, and public health. Surveillance data revealed that H5N1 HPAI has been detected in imported frozen duck meat from Asia, and on the surface and in contaminated eggs. However, there is no direct evidence that AI viruses can be transmitted to humans via the consumption of contaminated poultry products. Implementing management practices that incorporate biosecurity principles, personal hygiene, and cleaning and disinfection protocols, as well as cooking and processing standards, are effective means of controlling the spread of the AI viruses.

show abstract

Outbreak of low pathogenicity H7N3 avian influenza in UK, including associated case of human conjunctivitis

Abstract: On 26 April 2006, the veterinary authorities in the United Kingdom reported that there had been an outbreak of avian influenza type A/H7 among a 35 000-bird housed poultry flock in eastern England, United Kingdom.

Cited by 65 publications

References 0 publications

Structure and Receptor Complexes of the Hemagglutinin from a Highly Pathogenic H7N7 Influenza Virus

Structure and Receptor Complexes of the Hemagglutinin from a Highly Pathogenic H7N7 Influenza Virus

Protecting Poultry Workers from Exposure to Avian Influenza Viruses

Avian Influenza: Public Health and Food Safety Concerns

Contact Info

Product

Resources

About