Outbreak of Injection Abscesses Due to Mycobacterium abscessus

Inman, Peter

doi:10.1001/archderm.1969.01610260017003

Cited by 98 publications

(37 citation statements)

References 13 publications

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“…During our investigation of the outbreak, reported elsewhere (Inman, Brown, Beck & Stanford, 1969) we found that these strains were identical with a type strain of Mycobacterium abscessus. Further studies revealed that this identity extended to the type strains of several other allegedly different species.…”

Section: Introductionsupporting

confidence: 64%

Bacteriological and Serological Studies of Fast Growing Mycobacteria Identified as Mycobacterium friedmannii

Stanford

Beck

1969

Journal of General Microbiology

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SUMMARYThree recently isolated strains of a fast growing non-pigmented mycobacterium, two of which were from a series of injection abscesses and one which was recovered from a water tank, have been compared bacteriologically and serologically in gel-diffusion tests with a number of mycobacterial type strains. The three strains and type strains of M. abscessus, M. runyonii, M. borstelense and M. friedmannii were of one species. This species differed in several respects from M . ranae (fortuitum), M. smegmatis and M . thamnopheos. In view of the chronological priority of M . friedmannii over the other names, we recommend that this name be adopted as the correct designation for this species. The origin of the type strain of M. friedmannii is discussed and reasons are given for its acceptance as representative of Friedmann's original strains.

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Section: Introductionsupporting

confidence: 64%

Bacteriological and Serological Studies of Fast Growing Mycobacteria Identified as Mycobacterium friedmannii

Stanford

Beck

1969

Journal of General Microbiology

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“…The direct smear was positive, and the culture was positive for RGM. No cases of keratitis had occurred in this clinic before this outbreak, and no more cases of keratitis occurred after 12 Sterilization procedures. Reusable items submitted to autoclaving were the keratome and suction rings.…”

Section: Outbreakmentioning

confidence: 81%

“…Their ability to survive starvation, the resistance to free chlorine or glutaraldehyde observed in some strains, and their ubiquity in the environment create favorable conditions for the occurrence of infections when sterility precautions or disinfection procedures are disregarded (29,30). Many health care-associated outbreaks caused by M. abscessus or M. chelonae have been documented since the first report in 1969 (12). "Mycobacterium massiliense" and "Mycobacterium bolletii" have been recently described and proposed as M. chelonae-M. abscessus group members, but to date there are no reports concerning their isolation from environmental samples (1,4).…”

mentioning

confidence: 99%

An Outbreak of Keratitis Caused by Mycobacterium immunogenum

et al. 2006

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From 8 October to 12 November 2003, 36 patients underwent surgical correction of myopia in a São Paulo, Brazil, clinic. Five patients had clinical signs of infectious keratitis, and a Mycobacterium species with previously unreported patterns determined by PCR restriction enzyme analysis of the hsp65 gene and PCR restriction enzyme analysis of the 16S-23S rRNA internal transcribed spacer (ITS) was isolated from corneal scrapings from four of these patients. Subsequent evaluation by phenotypic tests and partial sequencing of the hsp65, sodA, rpoB, and 16S rRNA genes and the ITS supported the species identification as a variant of Mycobacterium immunogenum. The source of infection was not determined. The outbreak was caused by a single clone, as evidenced by identical pulsed-field gel electrophoresis and enterobacterial repetitive intergenic consensus-PCR profiles. This is the first report of an outbreak where this species was isolated from infected tissues.Species belonging to the Mycobacterium chelonae-abscessus group have been isolated from many environmental sources, including potable water and distribution systems, swimming pool water, metalworking fluids, and soil (9,28,30). Their ability to survive starvation, the resistance to free chlorine or glutaraldehyde observed in some strains, and their ubiquity in the environment create favorable conditions for the occurrence of infections when sterility precautions or disinfection procedures are disregarded (29, 30). Many health care-associated outbreaks caused by M. abscessus or M. chelonae have been documented since the first report in 1969 (12). "Mycobacterium massiliense" and "Mycobacterium bolletii" have been recently described and proposed as M. chelonae-M. abscessus group members, but to date there are no reports concerning their isolation from environmental samples (1, 4). Mycobacterium immunogenum is a recently described rapidly growing species of the M. chelonae-M. abscessus group and occupies the same ecological niche as other M. chelonae-M. abscessus group members. Clinical isolates include those causing disseminated cutaneous infections, catheter-related infections, septic arthritis, chronic pneumonia, pacemaker-related sepsis, and possible keratitis (17, 31). A single genotype was isolated from metalworking fluids at 10 different sites in six states in the United States, where hypersensitivity pneumonitis occurred among metal-grinding machinists, but M. immunogenum was not isolated from those patients (28). This species caused pseudooutbreaks related to bronchoalveolar lavage procedures in Missouri and Maryland, but to date no reports of outbreaks of infections caused by this species have emerged (31). From 8 October to 12 November 2003, 36 patients-71 eyes-had laser in situ keratomileusis (LASIK) performed in a private clinic located in the urban area of the city of São Paulo, Brazil. Among those patients, five had clinical signs of infectious keratitis, and a Mycobacterium species with a distinct PRA-hsp65 (PCR restriction enzyme analysis of the hsp...

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“…The viable bacilli inoculated into the lower trachea may have either been removed by the muco-ciliary escalator or killed by the immune system of the badger. M. chelonei, which was isolated from one of the badgers, is commonly found in soil and water and is occasionally the cause of post-injection abscesses in man (Inman et al 1969) and has rarely been isolated from both abscesses and normal lymph nodes of domestic species (Lepper & Corner, 1983).…”

Section: Discussionmentioning

confidence: 99%

Experimental infection of badgers (Meles meles) withMycobacterium bovis

Pritchard¹,

Stuart²,

Brewer³

et al. 1987

Epidemiol. Infect.

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SUMMARYThe intradermal inoculation of four badgers with small numbers of Mycobacterium bovis resulted in localized lesions with ulceration which slowly healed by 5 months after inoculation. Lesions of generalized tuberculosis were seen in three badgers, one of which died at 17 months post-inoculation and in the remaining two killed 22 months post-inoculation. In the fourth badger lesions were confined to the draining lymph node of the inoculation site but M. bovis was isolated from the liver. Monthly clinical sampling of faeces, urine, tracheal aspirate and inoculation site exudates detected only the excretion of M. bovis from the inoculation site of one badger. There were marked seasonal variations in body weight but significant weight loss was observed during the second year in all four badgers, particularly prior to death. Four badgers inoculated intratracheally with a similar inoculum of M. bovis and another two control badgers showed no evidence of infection with M. bovis.

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Outbreak of Injection Abscesses Due to Mycobacterium abscessus

Cited by 98 publications

References 13 publications

Bacteriological and Serological Studies of Fast Growing Mycobacteria Identified as Mycobacterium friedmannii

Bacteriological and Serological Studies of Fast Growing Mycobacteria Identified as Mycobacterium friedmannii

An Outbreak of Keratitis Caused by Mycobacterium immunogenum

Experimental infection of badgers (Meles meles) withMycobacterium bovis

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