Outbreak of<i>Burkholderia Cepacia</i>Bacteremia Traced to Contaminated Hospital Water Used for Dilution of an Alcohol Skin Antiseptic

Nasser, Rana M.; Rahi, Amal C.; Haddad, Mona F; Daoud, Ziad; Irani-Hakime, Noha; Almawi, Wassim Y.

doi:10.1086/502384

Cited by 81 publications

(44 citation statements)

References 39 publications

(30 reference statements)

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“…342,343 Many healthcareassociated outbreaks of Burkholderia infections associated with contaminated skin antiseptics, mouthwashes, ultrasound gels, medications, and medical devices have been described. [344][345][346][347][348][349][350][351][352][353][354][355][356][357][358][359][360][361][362] Other products that have become contaminated during use include nasal irrigation bottles contaminated with P. aeruginosa, 363,364 multiuse albuterol vials contaminated with B. cepacia, 348,357 acupuncture devices disinfected with glutaraldehyde contaminated with M. abscessus, 365 cosmetic surgical supplies contaminated with mycobacterial spp., and supplies used for liposuction. 366 Outbreaks of Achromobacter spp.…”

Section: Iiid2 Healthcare Sources: Water Surfaces Equipment Airmentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

344

382

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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

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Section: Iiid2 Healthcare Sources: Water Surfaces Equipment Airmentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

344

382

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“…One pseudoepidemic of bacteremia (34) and one outbreak of bacteremia (54) have been traced to contaminated alcohol used for skin antisepsis. These were traced to the use of intrinsically contaminated alcohol (34) and dilution of the alcohol with contaminated water (54).…”

Section: Antisepticsmentioning

confidence: 99%

Outbreaks Associated with Contaminated Antiseptics and Disinfectants

Weber

Rutala

Sickbert-Bennett

2007

Antimicrob Agents Chemother

185

139

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“…[1][2][3][4][5][6] These bacteria exhibit an extraordinary metabolic versatility, allowing their adaptation to a wide range of environments and emerged in the 1980s as life-threatening and difficult-to-treat pathogens among patients suffering from cystic fibrosis. 2 It is a non-fermenting, …”

Section: Introductionmentioning

confidence: 99%

Report on the newly emerging nosocomial Burkholderia cepacia in a tertiary hospital

Srinivasan

Arora

Sahai

2016

Medical Journal Armed Forces India

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IntroductionBurkholderia cepacia, formerly Pseudomonas cepacia, is widely distributed in natural and man-made habitats, and has been isolated from soil, plant and water. [1][2][3][4][5][6] These bacteria exhibit an extraordinary metabolic versatility, allowing their adaptation to a wide range of environments and emerged in the 1980s as life-threatening and difficult-to-treat pathogens among patients suffering from cystic fibrosis. 2 It is a non-fermenting, m e d i c a l j o u r n a l a r m e d f o r c e s i n d i a 7 2 ( 2 0 1 6 ) s 5 0 -s 5 3 a r t

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Outbreak ofBurkholderia CepaciaBacteremia Traced to Contaminated Hospital Water Used for Dilution of an Alcohol Skin Antiseptic

Abstract: This is potentially the largest single-source nosocomial bloodstream infection outbreak ever reported, and the first report of an alcohol skin antiseptic contaminated by tap water as a source for nosocomial bacteremia.

Cited by 81 publications

References 39 publications

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Outbreaks Associated with Contaminated Antiseptics and Disinfectants

Report on the newly emerging nosocomial Burkholderia cepacia in a tertiary hospital

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