Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective

Seynaeve, Damien; Augusseau-Rivière, Brigitte; Couturier, Pascal; Morel-Baccard, Christine; Landelle, Caroline; Bosson, Jean‐Luc; Gavazzi, G.; Mallaret, Marie-Reine

doi:10.1016/j.jamda.2019.03.015

Cited by 9 publications

(7 citation statements)

References 38 publications

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“…Living in a long-term care facility was the strongest predictors of SARS-CoV-2 infection and was reported by 21.6% of anti-SARS-CoV-2-positive participants ( n = 86/398). This connection was not unexpected [ 21 , 22 , 23 ], since long-term care facilities often have limited or no infection control programs [ 24 , 25 ] and are usually congregative settings where elderly people have greater exposure to infected patients in the case of respiratory outbreaks [ 26 , 27 , 28 ]. Therefore, our results emphasized the importance of implementing strategic bundles for infections prevention in long-term care facilities [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, our results emphasized the importance of implementing strategic bundles for infections prevention in long-term care facilities [ 29 ]. In this regard, educational interventions on healthcare providers’ knowledge, as well as active surveillance of suspected cases and implementation of barrier precautions, were shown to play a vital role in limiting the spread of other respiratory outbreaks [ 26 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Antibodies to SARS-CoV-2 in Italian Adults and Associated Risk Factors

Vena

Berruti

Adessi³

et al. 2020

JCM

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We aimed to assess the prevalence of and factors associated with anti- severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) positivity in a large population of adult volunteers from five administrative departments of the Liguria and Lombardia regions. A total of 3609 individuals were included in this analysis. Participants were tested for anti-SARS-CoV-2 antibodies [Immunoglobulin G (IgG) and M (IgM) class antibodies] at three private laboratories (Istituto Diganostico Varelli, Medical Center, and Casa della Salute di Genova). Demographic data, occupational or private exposure to SARS-CoV-2-infected patients, and prior medical history consistent with SARS-CoV-2 infection were collected according to a preplanned analysis. The overall seroprevalence of anti-SARS-CoV-2 antibodies (IgG and/or IgM) was 11.0% [398/3609; confidence interval (CI) 10.0%–12.1%]. Seroprevalence was higher in female inmates than in male inmates (12.5% vs. 9.2%, respectively, p = 0.002), with the highest rate observed among adults aged >55 years (13.2%). A generalized estimating equations model showed that the main risk factors associated with SARS-CoV-2 seroprevalence were the following: an occupational exposure to the virus [Odd ratio (OR) = 2.36; 95% CI 1.59–3.50, p = 0.001], being a long-term care facility resident (OR = 4.53; 95% CI 3.19–6.45, p = 0.001), and reporting previous symptoms of influenza-like illness (OR = 4.86; 95% CI 3.75–6.30, p = 0.001) or loss of sense of smell or taste (OR = 41.00; 95% CI 18.94–88.71, p = 0.001). In conclusion, we found a high prevalence (11.0%) of SARS-CoV-2 infection that is significantly associated with residing in long-term care facilities or occupational exposure to the virus. These findings warrant further investigation into SARS-CoV-2 antibody prevalence among the Italian population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of Antibodies to SARS-CoV-2 in Italian Adults and Associated Risk Factors

Vena

Berruti

Adessi³

et al. 2020

JCM

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“…28 Other than influenza and RSV, human metapneumovirus is the third most common causative pathogen for NH respiratory infection outbreaks. 30 NHs often do not have on-site equipment to evaluate suspected infection; therefore, a lower threshold for antibiotic prescription is common. It is estimated that approximately two-thirds of NH residents received antibiotics each year, and up to 75% of the treatment is inappropriate.…”

Section: Discussionmentioning

confidence: 99%

Combining Procalcitonin and Rapid Multiplex Respiratory Virus Testing for Antibiotic Stewardship in Older Adult Patients With Severe Acute Respiratory Infection

Lee

Chang

Mao

et al. 2020

Journal of the American Medical Directors Association

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“…It has been identified in 4%-16% of patients with RTI, where it often transmits by large aerosols and droplets of infected patients. Moreover, a nosocomial transmission has been reported in hospitalized patients and in skilled nursing facilities [5,6].…”

Section: Discussionmentioning

confidence: 99%

Pericardial Effusion and Tamponade Complicating Acute Pericarditis in a Human Metapneumovirus-Infected Adult: A Unique Case Report

Mihyawi¹,

Fath²,

Findakly³

et al. 2020

Cureus

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Acute pericarditis (AP), or pericardial sac inflammation, is a self-limited condition in healthy individuals. Viruses, including adenoviruses, enteroviruses, cytomegalovirus, and influenza virus, have been well documented to cause AP. In contrast, human metapneumovirus (hMPV), a relatively newer virus, has been described in a few cases to cause serious cardiac complications. Here we report a patient who developed an imminent cardiac tamponade associated with hMVP respiratory infection.

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Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective

Cited by 9 publications

References 38 publications

Prevalence of Antibodies to SARS-CoV-2 in Italian Adults and Associated Risk Factors

Prevalence of Antibodies to SARS-CoV-2 in Italian Adults and Associated Risk Factors

Combining Procalcitonin and Rapid Multiplex Respiratory Virus Testing for Antibiotic Stewardship in Older Adult Patients With Severe Acute Respiratory Infection

Pericardial Effusion and Tamponade Complicating Acute Pericarditis in a Human Metapneumovirus-Infected Adult: A Unique Case Report

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