Outbreak of botulism in a dairy herd in Turkey

Şentürk, Sezgin; Cihan, Hüseyin

doi:10.1186/2046-0481-60-8-481

Cited by 18 publications

(29 citation statements)

References 8 publications

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“…The symptoms observed in the affected buffaloes, including sudden death, sternal recumbency, inability to stand, and flaccid paralysis, were similar to those described in botulism outbreaks in ruminants, and the absence of macroscopic and microscopic pathological changes corroborated the results of previous studies, which reported the lack of major changes or the presence of mild changes (Senturk & Cihan 2007, Myllykoski et al 2009, Moreira et al 2014.…”

Section: Discussionsupporting

confidence: 79%

“…BoNTs are the most toxic biological substances known and are classified into eight serotypes (A-H) on the basis of their antigenic properties. Serotypes C and D are involved in botulism outbreaks in cattle in several countries (Dutra et al 2001, Martin 2003, Senturk & Cihan 2007, Myllykoski et al 2009, Brooks et al 2011, and the disease is considered endemic in South Africa, Australia, Brazil, and Israel (Krüger et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Type C waterborne botulism outbreaks in buffaloes (Bubalus bubalis) in the Amazon region

et al. 2017

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Botulism is a poisoning caused by botulinum neurotoxins (BoNTs). BoNTs serotypes C and D are involved in botulism outbreaks in cattle in several countries. Despite the high number of buffaloes worldwide, the real impact of botulism in buffaloes is not known, because it is not a notifiable disease in Brazil and only few studies have evaluated the occurrence of the disease in buffaloes. Those studies did not conduct diagnostic tests to confirm the presence of BoNTs. The objective of the present study was to describe three outbreaks of botulism in buffaloes in the Brazilian Amazon region considering epidemiological and clinical data as well as laboratory diagnosis to confirm the presence of BoNTs. The results of the bioassay were negative in the tissues and in feed samples, but positive for BoNT C in water samples. Confirmation of the occurrence of botulism in buffaloes allows the implementation of preventive strategies in susceptible herds. Waterborne botulism in buffaloes is prevented by ensuring the constant circulation of water collections and restricting the presence of dead animals and bones in order to prevent the accumulation of organic matter and the development of anaerobic conditions, which might favor the replication of Clostridium botulinum. Another measure that can be adopted is the shading of the pasture, in order to maintain the thermal comfort for the buffaloes and to avoid the excess of permanence of them in the water pools.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Type C waterborne botulism outbreaks in buffaloes (Bubalus bubalis) in the Amazon region

et al. 2017

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“…The common clinical findings in animals with botulism include loss of tongue tone, decreased upper eyelid and tail tone, decreased rumen motility, pupillar and anal reflexes, loss of appetite and ataxia [4,22] which were all observed in the present study.…”

Section: Discussionsupporting

confidence: 57%

“…BoNT blocks acetylcholine release at neuromusculer junction [3] . Affected cattle shows many symptoms that includes loss of tongue tone, decreased upper eyelid and tail tone, loss of appetite, ataxia and decreased ruminal movements [4] . Many types of silages are used extensively in ruminants feeding [5] .…”

Section: Introductionmentioning

confidence: 99%

Botulismuslu İneklerde Serum Haptoglobulin, Seruloplazmin ve Pseudokolinesteraz Seviyelerinin Değerlendirilmesi

Aytekin¹,

Kaya²,

Atalay³

2016

Kafkas Univ Vet Fak Derg

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The aim of this study was to determine serum pseudocholinesterase, rheumatoid factor, troponin I, C-reactive protein, caeruloplasmin, haptoglobin, urea, creatinin, creatinin kinase (CK), phosporus, calcium, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in cows with or without botulism. The study included 15 holstein cows aged two to five years as the botulism group and control group consisting of 10 healthy cows. The group included both pregnant and dry period cattle. Serum concentration of all the parameters were measured using an autoanalyzer and Nefelometre equipment BNII. Mice inoculation test was performed to make diagnosis and Clostridium Botulinum type C and D toxins were determined in silage and blood that cows with botulism. Serum troponin I, C-reactive protein, rheumatoid factor, creatinine, creatinine kinase, phosphorus, calcium and AST did not differ significantly between two groups. Biochemistry analysis of serum showed that in the botulism group haptoglobin, caeruloplasmin and urea were higher and that pseudocholinesterase and alanine aminotransferase were lower than in the control group. Serum haptoglobin, caeruloplasmin, urea, alanine aminotransferase and especially pseudocholinesterase concentrations may prove beneficial to the prognosis of botulism. Keywords: Botulism, Cow, Toxin, Pseudocholinesterase, Ceruloplasmin, Haptoglobin Botulismuslu İneklerde Serum Haptoglobulin, Seruloplazmin ve Pseudokolinesteraz Seviyelerinin Değerlendirilmesi ÖzetBu çalışmada botulismuslu ve sağlıklı ineklerde serum pseudokolinesteraz, seruloplazmin, haptoglobin, romatoid faktör, troponin I, C-reactive protein, üre, kreatin, kreatin kinaz (CK), alanine aminotransferase (ALT) ve aspartate aminotransferase (AST), fosfor ve kalsiyum seviyeleri araştırıldı. Çalışma ve kontrol grubunu gebe ve kuru dönemde iki ile beş yaşları arasında değişen 15 adet botulismuslu ve 10 adet sağlıklı holştayn inek oluşturdu. Parametrelerin serum düzeyleri Nefelometre BNII ve otoanalizör kullanılarak ölçüldü. Botilusmuslu hayvanların kan serumlarından ve silajdan fare inokulasyon testi yapılarak clostridium botulinum tip C ve tip D toksini tespit edildi. Serum troponin I, C-reactive protein, romatoid faktör, kreatin, kreatin kinaz, AST, fosfor ve kalsiyum seviyeleri botulismuslu ve sağlıklı ineklerde önemli bir değişiklik göstermedi. Botulismuslu ineklerde haptoglobin, seruloplazmin ve üre yüksek çıkarken, ALT ve pseudokolinesterazın sağlıklı ineklere göre daha düşük çıktığı tespit edildi. Botulismuslu ineklerde serum üre, ALT, haptoglobin, seruloplazmin ve özellikle pseudokolinesteraz düzeylerinin belirlenmesi botulismusun prognozuna faydalı olabileceği sonucuna varıldı.

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“…Cl. botulinum is classified into 7 or 8 different types (A, B, C (C 1 , C 2 ), D, E, F, G) depending on the antigen properties of the botulinum neurotoxins (BoNT) produced, with intoxication mostly appearing in cattle following the ingestion of neurotoxins of type C and D and, less frequently, of type B [5][6][7][8][9]. The clinical signs are caused by highly specific neurotoxins that inhibit the release of neurotransmitters by exocytosis, leading to paralysis [1,2,5].…”

Section: Historymentioning

confidence: 99%

Acute Type C Botulism with Fatal Consequences in a Holstein Breeding Establishment in Northern Italy

Tavella¹,

Morosetti²,

Caresia³

et al. 2014

Journal of Veterinary Science and Animal Husbandry

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Outbreak of botulism in a dairy herd in Turkey

Cited by 18 publications

References 8 publications

Type C waterborne botulism outbreaks in buffaloes (Bubalus bubalis) in the Amazon region

Type C waterborne botulism outbreaks in buffaloes (Bubalus bubalis) in the Amazon region

Botulismuslu İneklerde Serum Haptoglobulin, Seruloplazmin ve Pseudokolinesteraz Seviyelerinin Değerlendirilmesi

Acute Type C Botulism with Fatal Consequences in a Holstein Breeding Establishment in Northern Italy

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