Outbreak of Astrovirus in Adults with Acute Gastroenteritis in Korea

Hwang, Bo-Mi; Jung, Sun‐Young; Jeong, Hyun Ju; Chung, Gyung Tae; Kang, Yeon‐Ho; Yang, Seung Joon; Seo, Na Young; Shin, Tae Ha; Yoo, Cheon-Kwon; Lee, Deog‐Yong

doi:10.4172/2161-069x.s13-004

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Furthermore, it is likely that the higher prevalence rate may be due to the fact that ASV infection is frequently associated with the lack of a source of indoor water, and contaminated water sources such as boreholes, cisterns, communal taps, and rivers. [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

Screening for viral pathogens in the gastrointestinal tract from cases of sudden unexpected death in infancy at the Tygerberg Medico-legal Mortuary

Cupido,

de Beer

2023

Virol J

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Sudden and unexpected death in infancy (SUDI) may be triggered by an external risk or exposure. Intestinal infections with enteric viruses may disrupt the gut and enhance bacterial toxins present in SUDI cases. While diarrhoeal disease deaths have decreased worldwide, approximately half a million deaths still occur in children in Sub- Saharan Africa and South Asia. Furthermore, the role of viral enteropathogens in SUDI cases have not been investigated. The aim of this study was to describe specific viral pathogens in stool samples collected from SUDI cases and age-matched, apparently healthy infants in Cape Town, South Africa. Stool samples were collected from 176 SUDI cases between June 2017 and May 2018. In addition, stool samples were collected from the nappies of 30 age-matched, apparently healthy infants as a control group. Real-time polymerase chain reaction was performed on the stool samples for viral detection. A total of 111 SUDI cases were positive for viruses, with rotavirus (38.6%; 68/176) and norovirus GI and GII (30.0%; 53/176) were prevalent in SUDI cases. Adenovirus Type F was present in only 15.9% (28/176), astrovirus in 9.7% (17/176), and sapovirus in 0.6% (1/176) of cases. In the control samples, norovirus GII was detected most frequently (36.7%; 11/30), followed by rotavirus (33.3%; 10/30), and sapovirus in 6.7% (2/30). While there was no significant association between SUDI cases and enteric viruses, the majority of viruses were significantly associated with the seasons. The study confirms the importance of rotavirus vaccination and describes the significance of norovirus infection in children, post rotavirus vaccine introduction.

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Section: Discussionmentioning

confidence: 99%

Screening for viral pathogens in the gastrointestinal tract from cases of sudden unexpected death in infancy at the Tygerberg Medico-legal Mortuary

Cupido,

de Beer

2023

Virol J

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Epidemiology of Classic and Novel Human Astrovirus: Gastroenteritis and Beyond

Bosch

Pintó

et al. 2017

Viruses

160

173

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Since they were identified in 1975, human astroviruses have been considered one of the most important agents of viral acute gastroenteritis in children. However, highly divergent astroviruses infecting humans have been recently discovered and associated with extra-intestinal infections. The report of cases of fatal meningitis and encephalitis, especially in immunocompromised individuals, has broadened their disease spectrum. Although zoonotic transmission among animal and human astroviruses has not been clearly recognized, the genetic similarity between some human and animal viruses makes it likely to occur. This review provides an update on the epidemiology of both classic and novel human astroviruses, and a comprehensive view on confirmed or potential association between astrovirus and human disease.

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Outbreak of Astrovirus in Adults with Acute Gastroenteritis in Korea

Cited by 2 publications

References 12 publications

Screening for viral pathogens in the gastrointestinal tract from cases of sudden unexpected death in infancy at the Tygerberg Medico-legal Mortuary

Screening for viral pathogens in the gastrointestinal tract from cases of sudden unexpected death in infancy at the Tygerberg Medico-legal Mortuary

Epidemiology of Classic and Novel Human Astrovirus: Gastroenteritis and Beyond

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