Outbreak of adenovirus type 55 infection in Israel

Salama, Matanelle; Amitai, Ziva; Nutman, Amir; Gottesman-Yekutieli, Tamar; Sherbany, Hilda; Drori, Yaron; Mendelson, Ella; Carmeli, Yehuda; Mandelboim, Michal

doi:10.1016/j.jcv.2016.03.002

Cited by 32 publications

(26 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13, 14, 15 Ad55, an inter-typic recombinant of Ad11 and Ad14, emerged since 2005 in Singapore and subsequently appeared in China, France and Israel. 16, 17 As a highly virulent pathogen, Ad55 was associated with life-threatening pneumonia during recent outbreaks. 18, 19 Their unpredictable high morbidity and mortality in otherwise healthy immuno-competent adults render Ad14 and Ad55 potential threats to public health.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of neutralizing antibodies against adenovirus type 14 and 55 in healthy adults in Southern China

Zheng

Xiao

Feng

et al. 2017

Emerging Microbes & Infections

View full text Add to dashboard Cite

Re-emerging human adenovirus types 14 (Ad14) and 55 (Ad55) have caused severe respiratory diseases and even deaths during recent outbreaks. However, the seroprevalence of neutralizing antibodies (nAbs) in healthy adults, which may reflect previous circulation and help to predict potential outbreaks, remains unclear. In this study, we established micro-neutralizing (MN) assays on the basis of recombinant Ad14 and Ad55 reporter viruses, and we investigated serum nAbs in healthy blood donors from Southern China. We found that the overall seropositive rates were 24.8% and 22.4% for Ad14 and Ad55 nAbs, respectively. The seropositive rates were low in individuals younger than 20, and they gradually increased with age. Ad55-seropositive individuals tended to have high nAb titers (>1000), while low (72–200) and moderate (201–1000) nAb levels were frequently observed in Ad14-seropositive ones. Surprisingly, the seropositive rates and nAb levels were associated with the blood type but not the gender of the blood donors, with type AB individuals displaying higher seropositive rates and nAb levels. Interestingly, a significant positive correlation was observed between Ad14 and Ad55 seroprevalence, and higher titers of nAbs were detected in double-positive individuals compared to single-positive ones. These results clarified the human humoral immune responses against Ad14 and Ad55 and revealed a low level of herd immunity in some subpopulations, which emphasized the importance of monitoring these two highly virulent adenoviruses and reinforced the development of prophylactic vaccines.

show abstract

Section: Introductionmentioning

confidence: 99%

Seroprevalence of neutralizing antibodies against adenovirus type 14 and 55 in healthy adults in Southern China

Zheng

Xiao

Feng

et al. 2017

Emerging Microbes & Infections

View full text Add to dashboard Cite

show abstract

“…A question arises as to the prevalence of HAdV-B76 in the current population. Due to the "pregenomics" era and current protocols of using only one or two epitopes for HAdV identification and typing (56), there is a strong possibility that HAdV-B76, with its putative serotypes of HAdV-B21 and -B16, were and are mistyped as HAdV-B21 or -B16 and therefore unrecognized as an emergent recombinant, HAdV-B76. More likely, as most respiratory pathogenic HAdVs are neither commonly screened nor reported due to their insignificant mortality rates, it may be that HAdV-B76 is simply underreported.…”

mentioning

confidence: 99%

A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts

Dehghan

Seto

Liu

et al. 2019

J Virol

View full text Add to dashboard Cite

Genomics analysis of a historically intriguing and predicted emergent human adenovirus (HAdV) pathogen, which caused pneumonia and death, provides insight into a novel molecular evolution pathway involving “ping-pong” zoonosis and anthroponosis. The genome of this promiscuous pathogen is embedded with evidence of unprecedented multiple, multidirectional, stable, and reciprocal cross-species infections of hosts from three species (human, chimpanzee, and bonobo). This recombinant genome, typed as HAdV-B76, is identical to two recently reported simian AdV (SAdV) genomes isolated from chimpanzees and bonobos. Additionally, the presence of a critical adenoviral replication element found in HAdV genomes, in addition to genes that are highly similar to counterparts in other HAdVs, reinforces its potential as a human pathogen. Reservoirs in nonhuman hosts may explain periods of apparent absence and then reemergence of human adenoviral pathogens, as well as present pathways for the genesis of those thought to be newly emergent. The nature of the HAdV-D76 genome has implications for the use of SAdVs as gene delivery vectors in human gene therapy and vaccines, selected to avoid preexisting and potentially fatal host immune responses to HAdV. IMPORTANCE An emergent adenoviral human pathogen, HAdV-B76, associated with a fatality in 1965, shows a remarkable degree of genome identity with two recently isolated simian adenoviruses that contain cross-species genome recombination events from three hosts: human, chimpanzee, and bonobo. Zoonosis (nonhuman-to-human transmission) and anthroponosis (human to nonhuman transmission) may play significant roles in the emergence of human adenoviral pathogens.

show abstract

“…Novel types or genomic variants, such as HAdV-14 ( 3 ) and HAdV-7 ( 5 ), have been implicated in epidemics of severe infection. HAdV-55, another emerging type reported in China, Turkey, Spain, Singapore, and Israel ( 5 , 6 ), has been associated with severe clinical manifestations, which often lead to respiratory failure and death ( 7 , 8 ). …”

mentioning

confidence: 99%

Febrile Respiratory Illness Associated with Human Adenovirus Type 55 in South Korea Military, 2014–20161

Yoo¹,

Gu²,

Jung³

et al. 2017

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

Outbreak of adenovirus type 55 infection in Israel

Cited by 32 publications

References 35 publications

Seroprevalence of neutralizing antibodies against adenovirus type 14 and 55 in healthy adults in Southern China

Seroprevalence of neutralizing antibodies against adenovirus type 14 and 55 in healthy adults in Southern China

A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts

Febrile Respiratory Illness Associated with Human Adenovirus Type 55 in South Korea Military, 2014–20161

Contact Info

Product

Resources

About