Outbreak of acute viral hepatitis due to hepatitis E virus in Hyderabad

Sarguna, P; Rao, Agam K.; Ramana, KN Sudha

doi:10.4103/0255-0857.37343

Cited by 40 publications

(35 citation statements)

References 14 publications

(13 reference statements)

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“…Efforts by the local authorities to increase supply and improve treatment of water have been successful in dramatically reducing the incidence of gastroenteritis in the past decade with hospitalized cases dropping from 265/100,000 (Mahapatra & Reddy 2001) to approximately 100/100,000 (unpublished data from the MWB). However events such as the 2005 outbreak of water-borne viral hepatitis in slum areas with 546 confirmed cases (Sarguna et al 2007) indicates that waterborne illness remains a health burden.…”

Section: Introductionmentioning

confidence: 99%

Is fecal contamination of drinking water after collection associated with household water handling and hygiene practices? A study of urban slum households in Hyderabad, India

Eshcol

Mahapatra²,

Keshapagu³

2008

Journal of Water and Health

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Water-borne illness, primarily caused by fecal contamination of drinking water, is a major health burden in the state of Andhra Pradesh, India. Currently drinking water is treated at the reservoir level and supplied on alternate days, necessitating storage in households for up to 48 hrs. We hypothesized that fecal contamination occurs principally during storage due to poor water handling. In this study we tested for coliform bacteria in water samples collected at distribution points as household storage containers were filled, and then tested containers in the same households 24-36 hours after collection. We also conducted an observational survey to make an assessment of water handling and hygiene. Ninety-two percent (47/51) of samples tested at supply points were adequately chlorinated and bacterial contamination was found in two samples with no residual chlorine. Samples collected from household storage containers showed an increase in contamination in 18/50 houses (36%). Households with contaminated stored samples did not show significant differences in demographics, water handling, hygiene practices, or sanitation. Nevertheless, the dramatic increase in contamination after collection indicates that until an uninterrupted water supply is possible, the point at which the biggest health impact can be made is at the household level.

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Section: Introductionmentioning

confidence: 99%

Is fecal contamination of drinking water after collection associated with household water handling and hygiene practices? A study of urban slum households in Hyderabad, India

Eshcol

Mahapatra²,

Keshapagu³

2008

Journal of Water and Health

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“…The disease mainly affects young human adults and generally has a low mortality rate (1%), but this rate can rise to 25% in pregnant women (5,6). Transmission of the hepatitis E virus (HEV), the causative agent of hepatitis E, is mainly through the fecal-oral route, via contaminated food and water (7,10). HEV infection occurs not only in humans but also in animals, such as swine, wild boar, wild deer, and wild mongoose, and the disease can be considered an anthropozoonosis (2,4,8,12).…”

mentioning

confidence: 99%

Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Hepatitis E Virus

Lan

Yang

et al. 2009

J Clin Microbiol

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The one-step single-tube betaine-free reverse transcription (RT)-loop-mediated isothermal amplification assay was developed for rapid diagnosis of hepatitis E virus. This assay amplified the target gene in less than 45 min (even as short as 20 min) under isothermal conditions at 63°C, and the sensitivity of this assay was 100-fold greater than that of RT-PCR. This assay demonstrated a detection limit of 0.045 fg (nine copies/reaction).

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“…In addition to civilian cases, hepatitis E outbreaks have been documented in military population of Chad (2) , Djibouti (3) and Ethiopia (4) . In India (5,6,7) similar outbreaks of non-A, non-B enterically transmitted hepatitis have been reported periodically. HEV is enterically transmitted and causes sporadic outbreaks in young adults predominantly and could be fatal in pregnant women.…”

Section: Introductionmentioning

confidence: 90%

An Investigation and Management of Outbreak of Hepatitis E in South-Western India

Singh¹

2016

jmscr

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Outbreak of acute viral hepatitis due to hepatitis E virus in Hyderabad

Cited by 40 publications

References 14 publications

Is fecal contamination of drinking water after collection associated with household water handling and hygiene practices? A study of urban slum households in Hyderabad, India

Is fecal contamination of drinking water after collection associated with household water handling and hygiene practices? A study of urban slum households in Hyderabad, India

Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Hepatitis E Virus

An Investigation and Management of Outbreak of Hepatitis E in South-Western India

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