Outbreak of acute gastroenteritis caused by adenovirus type 41 in a kindergarten

Gonçalves, Guilherme; Gouveia, Edilane Lins; Mesquita, João R.; Almeida, Adelaide; Ribeiro, Andreia; Rocha‐Pereira, Joana; Nascimento, María Säo José

doi:10.1017/s0950268810002803

Cited by 14 publications

(12 citation statements)

References 10 publications

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“…Overall, the HAdV‐positive rate was 5.5% (113/2064), which is lower than that found in a previous study (8.7%; 20/231) in Korea during 1998–1999 (33). Although earlier studies reported that the incidence of HAdV‐40 and HAdV‐41 infections in acute gastroenteritis is similar (34, 35), more recent studies have reported a predominance of HAdV‐41 (17, 29, 36, 37).…”

Section: Discussionmentioning

confidence: 94%

Detection and molecular characterization of adenoviruses in Korean children hospitalized with acute gastroenteritis

Lee

Chung

et al. 2012

Microbiology and Immunology

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Human adenoviruses (HAdVs) are an important cause of acute gastroenteritis in children. However, few studies on the epidemiology or types of HAdVs associated with acute gastroenteritis have been conducted in Korea. Therefore, in the present study, the incidence of HAdV in 2064 stool samples from Korean children hospitalized with acute gastroenteritis (2004-2006) was assessed and the types of viruses present determined. Polymerase chain reaction, sequencing, and phylogenic analyses revealed that 113 samples (5.5%) were HAdV-positive. While HAdVs were mainly detected during July to October, no seasonal difference between the enteric and non-enteric viruses in the incidence of HAdV was observed. HAdV-41 and HAdV-40 were found in 54 (47.8%) and 3 (2.6%) HAdV-positive samples, respectively. HAdV-3, HAdV-7, HAdV-2, HAdV-31, HAdV-4, and HAdV-37 were detected in 11 (9.7%), 5 (4.4%), 2 (1.7%), 2 (1.7%), 1 (0.8%), and 1 (0.8%) of sample(s), respectively. Thus, not only enteric, but also non-enteric, HAdVs may play an important role in acute gastroenteritis in Korean children.

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Section: Discussionmentioning

confidence: 94%

Detection and molecular characterization of adenoviruses in Korean children hospitalized with acute gastroenteritis

Lee

Chung

et al. 2012

Microbiology and Immunology

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“…AdVs may cause epidemics of febrile respiratory illness (FRI), pharyngoconjunctival fever, 45 keratoconjunctivitis (KC), [46][47][48][49] or gastroenteritis and diarrheal illness. [50][51][52][53][54][55][56][57][58][59][60][61] Severe or disseminated AdV infections may occur in immunocompromised hosts 7,9,[62][63][64] and rarely in immunocompetent patients. 23,65 Most epidemics occur in the winter or early spring, 6 but infections occur throughout the year with no clear seasonality.…”

Section: Epidemiologymentioning

confidence: 99%

Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention

Lynch

Kajon

2016

Semin Respir Crit Care Med

404

178

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Adenoviruses (AdVs) are DNA viruses that typically cause mild infections involving the upper or lower respiratory tract, gastrointestinal tract, or conjunctiva. Rare manifestations of AdV infections include hemorrhagic cystitis, hepatitis, hemorrhagic colitis, pancreatitis, nephritis, or meningoencephalitis. AdV infections are more common in young children, due to lack of humoral immunity. Epidemics of AdV infection may occur in healthy children or adults in closed or crowded settings (particularly military recruits). The disease is more severe and dissemination is more likely in patients with impaired immunity (e.g., organ transplant recipients, human immunodeficiency virus infection). Fatality rates for untreated severe AdV pneumonia or disseminated disease may exceed 50%. More than 50 serotypes of AdV have been identified. Different serotypes display different tissue tropisms that correlate with clinical manifestations of infection. The predominant serotypes circulating at a given time differ among countries or regions, and change over time. Transmission of novel strains between countries or across continents and replacement of dominant viruses by new strains may occur. Treatment of AdV infections is controversial, as prospective, randomized therapeutic trials have not been conducted. Cidofovir is the drug of choice for severe AdV infections, but not all patients require treatment. Live oral vaccines are highly efficacious in reducing the risk of respiratory AdV infection and are in routine use in the military in the United States, but currently are not available to civilians.

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“…161 Severe and disseminated AdV infections, although rare in the immunocompetent host, 162,163 can occur in immunocompromised patients. [164][165][166][167][168][169][170][171][172][173][174][175] Augmented immunosuppression, including exposure to cytolytic therapies, is considered to be a risk factor for more severe disease in patients who experience AdV infection. 161 AdV infections are typically caused by exposure to infected respiratory secretions through person-to-person contact.…”

Section: Adenovirus Epidemiology and Transmissionmentioning

confidence: 99%

Respiratory Viral Infections in Hematopoietic Stem Cell and Solid Organ Transplant Recipients

Weigt

Gregson

Deng

et al. 2011

Semin Respir Crit Care Med

100

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Respiratory viral infections (RVIs) are common causes of mild illness in immunocompetent children and adults with rare occurrences of significant morbidity or mortality. Complications are more common in the very young, very old, and those with underlying lung diseases. However, RVIs are increasingly recognized as a cause of morbidity and mortality in recipients of hematopoietic stem cell transplants (HSCT) and solid organ transplants (SOTs). Diagnostic techniques for respiratory syncytial virus (RSV), parainfluenza, influenza, and adenovirus have been clinically available for decades, and these infections are known to cause serious disease in transplant recipients. Modern molecular technology has now made it possible to detect other RVIs including human metapneumovirus, coronavirus, and bocavirus, and the role of these viruses in causing serious disease in transplant recipients is still being worked out. This article reviews the current information regarding epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment of these infections, as well as the aspects of clinical significance of RVIs unique to HSCT or SOT.

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Outbreak of acute gastroenteritis caused by adenovirus type 41 in a kindergarten

Cited by 14 publications

References 10 publications

Detection and molecular characterization of adenoviruses in Korean children hospitalized with acute gastroenteritis

Detection and molecular characterization of adenoviruses in Korean children hospitalized with acute gastroenteritis

Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention

Respiratory Viral Infections in Hematopoietic Stem Cell and Solid Organ Transplant Recipients

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