Outbreak in Croatia caused by a new carbapenem-resistant clone of Acinetobacter baumannii producing OXA-72 carbapenemase

Goić-Barišić, Ivana; Towner, K. J.; Kovačić, Ana; Šiško-Kraljević, Katarina; Tonkić, Marija; Novak, Anita; Punda‐Polić, Volga

doi:10.1016/j.jhin.2010.12.003

Cited by 54 publications

(31 citation statements)

References 8 publications

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“…Hospital isolates were collected from clinical specimens and stored at the University Hospital Centre Split as described earlier by Goić-Barišić et al (20).…”

Section: Bacteriamentioning

confidence: 99%

Relationship between ultrasound bone parameters, lung function, and body mass index in healthy student population

Cvijetić

Pipinić

Varnai

et al. 2017

Archives of Industrial Hygiene and Toxicology

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The aim of this study was to determine the susceptibility of hospital and environmental Acinetobacter baumannii isolate biofilms on ceramics and glass to common disinfectants benzalkonium chloride and chlorhexidine. For this purpose we developed a new method for biofilm cultivation and quantification on ceramics. The biofilm bacteria were more resistant to disinfectants than the planktonic populations, as more than 50 % of the biofilm population and none of the planktonic population survived 5-minute exposure. Furthermore, biofilm populations on ceramic tiles were significantly more resistant than those on glass coverslips, even though the amount of biofilm was practically the same on ceramics and glass. The reason for reduced susceptibility of A. baumannii biofilms on ceramics may be related to surface/disinfection interactions. Our findings suggest that biofilms on ceramic surfaces can be an important source of A. baumannii infection in hospital environments.

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“…Hospital isolates were collected from clinical specimens and stored at the University Hospital Centre Split as described earlier by Goić-Barišić et al (20).…”

Section: Bacteriamentioning

confidence: 99%

Relationship between ultrasound bone parameters, lung function, and body mass index in healthy student population

Cvijetić

Pipinić

Varnai

et al. 2017

Archives of Industrial Hygiene and Toxicology

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“…We compared the A. baumannii strain isolated from paleosol with three different isolates: a clinical isolate of A. baumannii from a general hospital in Pula, Istria, belonging to a multicenter collection and two clinical isolates belonging to European (international) clones I and II that are causing outbreaks in Croatia (20,21). The general hospital in Pula is situated in the area where our environmental isolate was found, so we supposed that our environmental isolate could be similar to the clinical isolate from this region.…”

Section: Characterization Of Paleosolmentioning

confidence: 99%

“…8) and that these isolates represent a cluster within European clone I. European clone I has been recognized as a cause of nosocomial infection in Croatia for more than 10 years, and for a long time it has been the dominant clone causing hospital outbreaks (20). However, the carbapenem resistance pattern of the clinical isolate in Pula displays reduced susceptibility to imipenem and meropenem (MICs, 8 to 16 mg/liter), and it carries a bla OXA-69-like gene associated with ISAba1, a well-described mechanism of carbapenem resistance in Croatia in the past decade (20,21).…”

Section: Fig 6 Sem Photograph Of Weathered Pyritementioning

confidence: 99%

Occurrence of an Environmental Acinetobacter baumannii Strain Similar to a Clinical Isolate in Paleosol from Croatia

Hrenović

Durn

Goić-Barišić

et al. 2014

Appl Environ Microbiol

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dOver the past decade, bacteria of the genus Acinetobacter have emerged as a leading cause of hospital-acquired infections. Outbreaks of Acinetobacter infections are considered to be caused exclusively by contamination and transmission in hospital environments. The natural habitats of clinically important multiresistant Acinetobacter spp. remain to be defined. In this paper, we report an incidental finding of a viable multidrug-resistant strain of Acinetobacter baumannii, related to clinical isolates, in acid paleosol from Croatia. The environmental isolate of A. baumannii showed 87% similarity to a clinical isolate originating from a hospital in this geographic area and was resistant to gentamicin, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin. In paleosol, the isolate was able to survive a low pH (3.37), desiccation, and a high temperature (50°C). The probable source of A. baumannii in paleosol is illegally disposed waste of external origin situated in the abandoned quarry near the sampling site. The bacteria could have been leached from waste by storm water and thus infiltrated the paleosol.

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“…This species emerged over the last decade as a leading cause of hospital-acquired infections; there are numerous reports of multidrug-resistant (MDR) A. baumannii from hospitals around the world 6 including Croatia. 7,8 Problems caused by A. baumannii in the hospital setting are emphasized by high degree of resistance to drying and disinfectants, leading to longterm persistence and the occurrence of outbreaks in the hospital environment. 6 Global outbreaks of infections caused by A. baumannii are also frequent.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii

Ćurković‐Perica¹,

Hrenović²,

Kugler³

et al. 2015

Croat. Chem. Acta

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Abstract. The aim of this research was to test the antibacterial activity of Pinus pinaster aqueous bark extract (PABE) and its basic components against multidrug-resistant isolates of Acinetobacter baumannii belonging to European clone I and II, isolated previously from the clinical outbreaks. The minimum bactericidal concentration of PABE against both clones of A. baumannii was 200 mg ml -1 , while lower concentrations showed high antibacterial activity. After 24 h of treatment with 100, 50 or 10 mg ml -1 of extract, the reduction in the number of A. baumannii isolates belonging to European clone I and II was 85.8 ± 2.5 %, 78.5 ± 1.1 %, 66.3 ± 2.5 % and 90.2 ± 1.7 %, 78.6 ± 1.2 %, 69.8 ± 0.7 %, respectively. Several basic components: caffeic acid, catechin, epicatechin, gallic acid and vanillin, detected in the extract by high performance liquid chromatography, contributed to the antibacterial activity of the extract against both clones of A. baumannii. However, the antibacterial activity of extract was higher than that of each tested basic component suggesting that proanthocyanidins, which were present in quite a large amount in the extract, might have also contributed to the activity of the extract. Antibacterial activity of PABE against A. baumannii reveals that complex and inexpensive natural product might be useful in combat against naturally competent bacteria that easily acquire resistance against antibiotics.

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Outbreak in Croatia caused by a new carbapenem-resistant clone of Acinetobacter baumannii producing OXA-72 carbapenemase

Cited by 54 publications

References 8 publications

Relationship between ultrasound bone parameters, lung function, and body mass index in healthy student population

Relationship between ultrasound bone parameters, lung function, and body mass index in healthy student population

Occurrence of an Environmental Acinetobacter baumannii Strain Similar to a Clinical Isolate in Paleosol from Croatia

Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii

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