Out of control? Acting out anger is associated with deficient prefrontal emotional action control in male patients with borderline personality disorder

Bertsch, Katja; Krauch, Marlene; Roelofs, Karin; Cackowski, Sylvia; Herpertz, Sabine C.; Volman, Inge

doi:10.1016/j.neuropharm.2018.12.010

Cited by 31 publications

(20 citation statements)

References 50 publications

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“…However, some findings also show a hypoactivation in the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC), but strong activity in amygdala (Fulwiler et al, 2012; Siep et al, 2018). A meta-analysis study confirmed enhanced activation in the left amygdala to angry stimuli (Bertsch et al, 2018; Krauch et al, 2018). These controversies might be due to the fact that amygdala activity is related to initiation of fear, while activation of the orbitofrontal cortex is involved in the fear extinction (Milad and Rauch, 2007; Siep et al, 2018).…”

Section: Fmri Data On Basic Emotionsmentioning

confidence: 77%

An Integrative Way for Studying Neural Basis of Basic Emotions With fMRI

Wang

Cao

et al. 2019

Front. Neurosci.

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How emotions are represented in the nervous system is a crucial unsolved problem in the affective neuroscience. Many studies are striving to find the localization of basic emotions in the brain but failed. Thus, many psychologists suspect the specific neural loci for basic emotions, but instead, some proposed that there are specific neural structures for the core affects, such as arousal and hedonic value. The reason for this widespread difference might be that basic emotions used previously can be further divided into more “basic” emotions. Here we review brain imaging data and neuropsychological data, and try to address this question with an integrative model. In this model, we argue that basic emotions are not contrary to the dimensional studies of emotions (core affects). We propose that basic emotion should locate on the axis in the dimensions of emotion, and only represent one typical core affect (arousal or valence). Therefore, we propose four basic emotions: joy-on positive axis of hedonic dimension, sadness-on negative axis of hedonic dimension, fear, and anger-on the top of vertical dimensions. This new model about basic emotions and construction model of emotions is promising to improve and reformulate neurobiological models of basic emotions.

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Section: Fmri Data On Basic Emotionsmentioning

confidence: 77%

An Integrative Way for Studying Neural Basis of Basic Emotions With fMRI

Wang

Cao

et al. 2019

Front. Neurosci.

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“…While it has been proposed that diminished prefrontal control of the amygdala underlies clinically observed problems in emotion regulation and impulse control, this model has been challenged due to methodological problems, e.g., a lack of spatial and disease specificity [109,110]. Reduced activity in dorsolateral and orbitofrontal regions has been observed in subgroups of patients who show anger-related aggression [111], but its role in deficient emotion dysregulation in BPD remains elusive [109].…”

Section: Neuroimaging Studies On Dissociation In Bpdmentioning

confidence: 99%

Dissociation in Borderline Personality Disorder: Recent Experimental, Neurobiological Studies, and Implications for Future Research and Treatment

Krause-Utz

Frost

Chatzaki

et al. 2021

Curr Psychiatry Rep

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Purpose of Review The aim of this review article is to give an overview over recent experimental neurobiological research on dissociation in borderline personality disorder (BPD), in order to inform clinicians and to stimulate further research. First, we introduce basic definitions and models that conceptualize dissociation from a transdiagnostic perspective. Then, we discuss recent findings in BPD. Recent Findings Stress-related dissociation is a key symptom of BPD, closely linked to other core domains of the disorder (emotion dysregulation, identity disturbances, and interpersonal disturbances). The understanding of neurobiological correlates of dissociation across different psychiatric disorders (e.g., dissociative disorders, post-traumatic stress disorder) is steadily increasing. At the same time, studies explicitly focusing on dissociation in BPD are still scarce. Summary There is evidence for adverse effects of dissociation on affective-cognitive functioning (e.g., interference inhibition), body perception, and psychotherapeutic treatment response in BPD. On the neural level, increased activity in frontal regions (e.g., inferior frontal gyrus) and temporal areas (e.g., inferior and superior temporal gyrus) during symptom provocation tasks and during resting state was observed, although findings are still diverse and need to be replicated. Conceptual differences and methodological differences in study designs and sample characteristics (e.g., comorbidities, trauma history) hinder a straightforward interpretation and comparison of studies. Given the potentially detrimental impact of dissociation in BPD, more research on the topic is strongly needed to deepen the understanding of this complex clinical condition.

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“…We were interested in the distinct pattern of activation related to emotional regulation, however only six studies specifically addressed emotional modulation in BPD [28][29][30][31][32][33] , too few for a meta-analysis. As impulsivity is a key feature of BPD 17 with specific brain correlates only partially overlapping with the broader emotional circuits, we considered these studies separately.…”

Section: Sensitivity Analyses For Primary Analysismentioning

confidence: 99%

Parsing variability in borderline personality disorder: a meta-analysis of neuroimaging studies

et al. 2021

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Though a plethora of functional magnetic resonance imaging (fMRI) studies explored the neurobiological underpinnings of borderline personality disorder (BPD), findings across different tasks were divergent. We conducted a systematic review and activation likelihood estimation (ALE) meta-analysis on the fMRI studies conducted in BPD patients compared to healthy controls (HC). We systematically searched PubMed and PsychINFO from inception until July 9th 2020 using combinations of database-specific terms like ‘fMRI’, ‘Neuroimaging’, ‘borderline’. Eligible studies employed task-based fMRI of the brain in participants of any age diagnosed with BPD compared to HC, during any behavioral task and providing a direct contrast between the groups. From 762 entries, we inspected 92 reports full-texts and included 52 studies (describing 54 experiments). Across all experiments, the HC > BPD and BPD > HC meta-analyses did not yield any cluster of significant convergence of differences. Analyses restricted to studies of emotion processing revealed two significant clusters of activation in the bilateral hippocampal/amygdala complex and anterior cingulate for the BPD > HC meta-analysis. Fail-safe N and single study sensitivity analysis suggested significant findings were not robust. For the subgroup of emotional processing experiments, on a restricted number of experiments providing results for each group separately, another meta-analysis method (difference of convergence) showed a significant cluster in the insula/inferior frontal gyrus for the HC > BPD contrast. No consistent pattern of alteration in brain activity for BPD was evidenced suggesting substantial heterogeneity of processes and populations studied. A pattern of amygdala dysfunction emerged across emotion processing tasks, indicating a potential pathophysiological mechanism that could be transdiagnostic.

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Out of control? Acting out anger is associated with deficient prefrontal emotional action control in male patients with borderline personality disorder

Cited by 31 publications

References 50 publications

An Integrative Way for Studying Neural Basis of Basic Emotions With fMRI

An Integrative Way for Studying Neural Basis of Basic Emotions With fMRI

Dissociation in Borderline Personality Disorder: Recent Experimental, Neurobiological Studies, and Implications for Future Research and Treatment

Parsing variability in borderline personality disorder: a meta-analysis of neuroimaging studies

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