Indian major carps (IMCs) are of great importance in freshwater aquaculture across the Indian subcontinent. This review article presents a comprehensive approach to successfully cultivating IMCs in aquaculture ponds. It covers various aspects, including taxonomy, pond preparation, broodstock maintenance, nutritional requirements, health management, water management, and biosecurity. The overview section highlights the ecological significance, economic contributions, and distribution of IMCs in the region. A detailed taxonomic classification facilitates proper species identification and management. Pond preparation is critical for optimal growth and reproduction of IMCs, with considerations such as pond design, soil quality, water source, and liming outlined. Maintaining healthy brood stock is vital for consistent production and genetic integrity. The article covers broodstock selection, breeding techniques, and management practices. Nutritional requirements are thoroughly addressed, with essential nutrients, feed formulations, and feeding strategies discussed for different life stages. Effective health management practices are pivotal in mitigating diseases and promoting fish welfare, with preventive and therapeutic measures, vaccination, and disease surveillance protocols explored. Water management principles, including quality monitoring, oxygenation, and nutrient management, are discussed for a healthy environment. Lastly, biosecurity measures are emphasized to prevent disease introduction and spread, with protocols for quarantine, disinfection, and farm isolation presented. In conclusion, this comprehensive review provides valuable insights into an integrated approach for successful Indian major carp aquaculture, promoting sustainable practices for improved productivity and long-term viability.