Our Experience Using Artificial Skin Grafts Arising from Calf Skin and Collagen.

Goto, Hidefumi; Higa, Eisyu; Kanbara, Mitsuyoshi; Haraga, Isao

doi:10.5035/nishiseisai.47.679

Cited by 1 publication

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AD-T is a dermal defect graft in which a silicon film has been added to the upper part of an artificial dermis made from processed atelocollagen in order to prevent exogenous infection and adjust permeability to exudates [ 15 ]. Atelocollagen, the raw material of AD-T, is a bovine dermis-derived type I collagen, which has a rod-shaped molecule (300 nm in length and 1.5 nm in width) in which three polypeptide chains with repeated sequences of Gly-Pro-Hyp amino acids form a helix; the molecule has non-helical telopeptides at both terminal ends [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…While the collagen sponge is gradually decomposed and absorbed, new collagen is produced by the proliferating fibroblasts and is replaced by a new dermis-like tissue in 2 to 3 weeks [ 17 ]. AD-T has shown excellent clinical outcomes not only in skin defect wounds but also in oral mucosal defects [ 15 , 17 , 19 , 20 , 21 , 22 ]. Furthermore, since the silicon membrane attached to AD-T is processed using a polyester mesh, it can be sutured and fixed to the surrounding tissue [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model

et al. 2022

View full text Add to dashboard Cite

In oral surgery, tissue loss may occur in some cases, resulting in bone exposure and subsequent wound infection and possible scar formation during secondary healing. In this study, Terudermis ® Artificial Dermis (AD-T), a dermal defect graft made from processed bovine dermis collagen and gelatin sponge (GS) were used as dressings on 100-mm 2 wounds with exposed bone on the heads of rats. For the control group, the wound was left exposed. The wound-healing efficacy of the treatment was compared macroscopically and histologically among the three groups at 1, 2, and 4 weeks after surgery. Complete wound healing was achieved faster in the AD-T group than in the GS group, and osteoblasts appeared on the bone surface, indicating accelerated bone remodeling. Furthermore, in the AD-T group, there was an increased production of newly formed blood vessels, fibroblasts and osteoblasts positive for anti-cortactin antibodies, which are believed to contribute to wound healing. Our findings suggest that AD-T is better than GS as a wound dressing material.

show abstract

Section: Discussionmentioning

confidence: 99%